Curvature-Regulated Lipid Membrane Softening of Nano-Vesicles
The physico-mechanical properties of nanoscale lipid vesicles (e.g., natural nano-vesicles and artificial nano-liposomes) dictate their interaction with biological systems. Understanding the interplay between vesicle size and stiffness is critical to both the understanding of the biological functions of natural nano-vesicles and the optimization of nano-vesicle-based diagnostics and therapeutics. It has been predicted that, when vesicle size is comparable to its membrane thickness, the effective bending stiffness of the vesicle increases dramatically due to both the entropic effect as a result of reduced thermal undulation and the nonlinear curvature elasticity effect. Through systematic molecular dynamics simulations, we show that the vesicle membrane thins and softens with the decrease in vesicle size, which effectively counteracts the stiffening effects as already mentioned. Our simulations indicate that the softening of nano-vesicles results from a change in the bilayer's interior structure - a decrease in lipid packing order - as the membrane curvature increases. Our work thus leads to a more complete physical framework to understand the physico-mechanical properties of nanoscale lipid vesicles, paving the way to further advances in the biophysics of nano-vesicles and their biomedical applications.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
|---|---|
| Enthalten in: |
Extreme Mechanics Letters - 43(2021) vom: 15. Feb. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chng, Choon-Peng [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Curvature |
|---|
| Anmerkungen: |
Date Revised 02.02.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1016/j.eml.2021.101174 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM321035836 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM321035836 | ||
| 003 | DE-627 | ||
| 005 | 20231225174945.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eml.2021.101174 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1070.xml |
| 035 | |a (DE-627)NLM321035836 | ||
| 035 | |a (NLM)33542946 | ||
| 035 | |a (PII)101174 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chng, Choon-Peng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Curvature-Regulated Lipid Membrane Softening of Nano-Vesicles |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 02.02.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a The physico-mechanical properties of nanoscale lipid vesicles (e.g., natural nano-vesicles and artificial nano-liposomes) dictate their interaction with biological systems. Understanding the interplay between vesicle size and stiffness is critical to both the understanding of the biological functions of natural nano-vesicles and the optimization of nano-vesicle-based diagnostics and therapeutics. It has been predicted that, when vesicle size is comparable to its membrane thickness, the effective bending stiffness of the vesicle increases dramatically due to both the entropic effect as a result of reduced thermal undulation and the nonlinear curvature elasticity effect. Through systematic molecular dynamics simulations, we show that the vesicle membrane thins and softens with the decrease in vesicle size, which effectively counteracts the stiffening effects as already mentioned. Our simulations indicate that the softening of nano-vesicles results from a change in the bilayer's interior structure - a decrease in lipid packing order - as the membrane curvature increases. Our work thus leads to a more complete physical framework to understand the physico-mechanical properties of nanoscale lipid vesicles, paving the way to further advances in the biophysics of nano-vesicles and their biomedical applications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Curvature | |
| 650 | 4 | |a Elastic modulus | |
| 650 | 4 | |a Lipid membrane | |
| 650 | 4 | |a Molecular simulation | |
| 650 | 4 | |a Stiffness | |
| 650 | 4 | |a Vesicle | |
| 700 | 1 | |a Sadovsky, Yoel |e verfasserin |4 aut | |
| 700 | 1 | |a Hsia, K Jimmy |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Changjin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Extreme Mechanics Letters |d 2014 |g 43(2021) vom: 15. Feb. |w (DE-627)NLM249525348 |x 2352-4316 |7 nnns |
| 773 | 1 | 8 | |g volume:43 |g year:2021 |g day:15 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.eml.2021.101174 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 43 |j 2021 |b 15 |c 02 | ||