Risk factors for diabetic foot complications in type 2 diabetes-A systematic review
© 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd..
Aims: With increasing numbers of patients with type 2 diabetes mellitus (T2DM) worldwide, the number of associated diabetic foot complications might also increase. This systematic review was performed to summarize published data about risk factors for the diabetic foot (DF) syndrome in order to improve the identification of high-risk patients.
Materials and methods: Six electronic databases were searched for publications up to August 2019 using predefined stringent inclusion and exclusion criteria.
Results: Of 9,476 identified articles, 31 articles from 28 different study populations fulfilled the criteria for our evaluation. The overall quality of the studies was good, and the risk of bias was low. There was large heterogeneity among the studies concerning study protocols and patient populations analysed. A total of 79 risk factors were analysed within this review. The majority of studies described a consistently positive association with different outcomes of interest related to DF for gender, peripheral neuropathy, retinopathy, nephropathy, poor glycaemic control, insulin use, duration of diabetes, smoking and height. For age, hypertension, dyslipidaemia and body mass index, the results remain inconsistent.
Conclusion: A most up-to-date literature review resulted in glycaemic control and smoking as the only amenable risk factors with a consistently positive association for DF. Due to the high personal and financial burden associated with DF and the large heterogeneity among included studies, additional longitudinal studies in large patient populations are necessary to identify more modifiable risk factors that can be used in the prediction and prevention of DF complications.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
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| Enthalten in: |
Endocrinology, diabetes & metabolism - 4(2021), 1 vom: 27. Jan., Seite e00175 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rossboth, Sophia [VerfasserIn] |
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| Links: |
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| Themen: |
Diabetic foot |
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| Anmerkungen: |
Date Completed 19.10.2021 Date Revised 30.03.2024 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1002/edm2.175 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320934608 |
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| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. | ||
| 520 | |a Aims: With increasing numbers of patients with type 2 diabetes mellitus (T2DM) worldwide, the number of associated diabetic foot complications might also increase. This systematic review was performed to summarize published data about risk factors for the diabetic foot (DF) syndrome in order to improve the identification of high-risk patients | ||
| 520 | |a Materials and methods: Six electronic databases were searched for publications up to August 2019 using predefined stringent inclusion and exclusion criteria | ||
| 520 | |a Results: Of 9,476 identified articles, 31 articles from 28 different study populations fulfilled the criteria for our evaluation. The overall quality of the studies was good, and the risk of bias was low. There was large heterogeneity among the studies concerning study protocols and patient populations analysed. A total of 79 risk factors were analysed within this review. The majority of studies described a consistently positive association with different outcomes of interest related to DF for gender, peripheral neuropathy, retinopathy, nephropathy, poor glycaemic control, insulin use, duration of diabetes, smoking and height. For age, hypertension, dyslipidaemia and body mass index, the results remain inconsistent | ||
| 520 | |a Conclusion: A most up-to-date literature review resulted in glycaemic control and smoking as the only amenable risk factors with a consistently positive association for DF. Due to the high personal and financial burden associated with DF and the large heterogeneity among included studies, additional longitudinal studies in large patient populations are necessary to identify more modifiable risk factors that can be used in the prediction and prevention of DF complications | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Systematic Review | |
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| 650 | 4 | |a foot ulceration | |
| 650 | 4 | |a lower extremity amputation | |
| 650 | 4 | |a risk factors | |
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