Bortezomib-loaded lipidic-nano drug delivery systems; formulation, therapeutic efficacy, and pharmacokinetics
AIM: Nano drug delivery systems can provide the opportunity to reduce side effects and improve the therapeutic aspect of a variety of drugs. Bortezomib (BTZ) is a proteasome inhibitor approved for the treatment of multiple myeloma and mantle cell lymphoma. Severe side effects of BTZ are the major dose-limiting factor. Particulate drug delivery systems for BTZ are polymeric and lipidic drug delivery systems. This review focussed on lipidic-nano drug delivery systems (LNDDSs) for the delivery of BTZ.
RESULTS: LNDDSs including liposomes, solid lipid nanoparticles, and self-nanoemulsifying drug delivery systems showed reduce systemic side effects, improved therapeutic efficacy, and increased intestinal absorption. Besides LNDDSs were used to target-delivery of BTZ to cancer.
CONCLUSION: Overall, LNDDSs can be considered as a novel delivery system for BTZ to resolve the treatment-associated restrictions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Journal of microencapsulation - 38(2021), 3 vom: 02. Mai, Seite 192-202 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mahmoudian, Mohammad [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.11.2021 Date Revised 21.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2021.1876175 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320917207 |
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| 100 | 1 | |a Mahmoudian, Mohammad |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Bortezomib-loaded lipidic-nano drug delivery systems; formulation, therapeutic efficacy, and pharmacokinetics |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 12.11.2021 | ||
| 500 | |a Date Revised 21.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: Nano drug delivery systems can provide the opportunity to reduce side effects and improve the therapeutic aspect of a variety of drugs. Bortezomib (BTZ) is a proteasome inhibitor approved for the treatment of multiple myeloma and mantle cell lymphoma. Severe side effects of BTZ are the major dose-limiting factor. Particulate drug delivery systems for BTZ are polymeric and lipidic drug delivery systems. This review focussed on lipidic-nano drug delivery systems (LNDDSs) for the delivery of BTZ | ||
| 520 | |a RESULTS: LNDDSs including liposomes, solid lipid nanoparticles, and self-nanoemulsifying drug delivery systems showed reduce systemic side effects, improved therapeutic efficacy, and increased intestinal absorption. Besides LNDDSs were used to target-delivery of BTZ to cancer | ||
| 520 | |a CONCLUSION: Overall, LNDDSs can be considered as a novel delivery system for BTZ to resolve the treatment-associated restrictions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Bortezomib | |
| 650 | 4 | |a formulation | |
| 650 | 4 | |a liposomes | |
| 650 | 4 | |a pharmacokinetics | |
| 650 | 4 | |a self-nanoemulsifying drug delivery systems | |
| 650 | 4 | |a solid lipid nanoparticles | |
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| 700 | 1 | |a Valizadeh, Hadi |e verfasserin |4 aut | |
| 700 | 1 | |a Löbenberg, Raimar |e verfasserin |4 aut | |
| 700 | 1 | |a Zakeri-Milani, Parvin |e verfasserin |4 aut | |
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