NeuroExercise : The Effect of a 12-Month Exercise Intervention on Cognition in Mild Cognitive Impairment-A Multicenter Randomized Controlled Trial
Copyright © 2021 Stuckenschneider, Sanders, Devenney, Aaronson, Abeln, Claassen, Guinan, Lawlor, Meeusen, Montag, Olde Rikkert, Polidori, Reuter, Schulz, Vogt, Weber, Kessels and Schneider..
Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(-0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [-1.76 (-3.39, -0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO2peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02913053, identifier: NCT02913053.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in aging neuroscience - 12(2020) vom: 08., Seite 621947 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stuckenschneider, Tim [VerfasserIn] |
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| Links: |
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| Themen: |
Aerobic exercise |
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| Anmerkungen: |
Date Revised 02.02.2021 published: Electronic-eCollection ClinicalTrials.gov: NCT02913053 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fnagi.2020.621947 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320806324 |
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| 520 | |a Copyright © 2021 Stuckenschneider, Sanders, Devenney, Aaronson, Abeln, Claassen, Guinan, Lawlor, Meeusen, Montag, Olde Rikkert, Polidori, Reuter, Schulz, Vogt, Weber, Kessels and Schneider. | ||
| 520 | |a Exercise intervention studies in mild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD), have demonstrated inconsistent yet promising results. Addressing the limitations of previous studies, this trial investigated the effects of a 12-month structured exercise program on the progression of MCI. The NeuroExercise study is a multicenter randomized controlled trial across three European countries (Ireland, Netherlands, Germany). Hundred and eighty-three individuals with amnestic MCI were included and were randomized to a 12-month exercise intervention (3 units of 45 min) of either aerobic exercise (AE; n = 60), stretching and toning exercise (ST; n = 65) or to a non-exercise control group (CG; n = 58). The primary outcome, cognitive performance, was determined by an extensive neuropsychological test battery. For the primary complete case (CC) analyses, between-group differences were analyzed with analysis of covariance under two conditions: (1) the exercise group (EG = combined AE and ST groups) compared to the CG and (2) AE compared to ST. Primary analysis of the full cohort (n = 166, 71.5 years; 51.8% females) revealed no between-group differences in composite cognitive score [mean difference (95% CI)], 0.12 [(-0.03, 0.27), p = 0.13] or in any cognitive domain or quality of life. VO2 peak was significantly higher in the EG compared to the CG after 12 months [-1.76 (-3.39, -0.10), p = 0.04]. Comparing the two intervention groups revealed a higher VO2peak level in the aerobic exercise compared to the stretching and toning group, but no differences for the other outcomes. A 12-month exercise intervention did not change cognitive performance in individuals with amnestic MCI in comparison to a non-exercise CG. An intervention effect on physical fitness was found, which may be an important moderator for long term disease progression and warrants long-term follow-up investigations. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT02913053, identifier: NCT02913053 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a aerobic exercise | |
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| 700 | 1 | |a Sanders, Marit L |e verfasserin |4 aut | |
| 700 | 1 | |a Devenney, Kate E |e verfasserin |4 aut | |
| 700 | 1 | |a Aaronson, Justine A |e verfasserin |4 aut | |
| 700 | 1 | |a Abeln, Vera |e verfasserin |4 aut | |
| 700 | 1 | |a Claassen, Jurgen A H R |e verfasserin |4 aut | |
| 700 | 1 | |a Guinan, Emer |e verfasserin |4 aut | |
| 700 | 1 | |a Lawlor, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a Meeusen, Romain |e verfasserin |4 aut | |
| 700 | 1 | |a Montag, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Olde Rikkert, Marcel G M |e verfasserin |4 aut | |
| 700 | 1 | |a Polidori, M Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Reuter, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Schulz, Ralf-Joachim |e verfasserin |4 aut | |
| 700 | 1 | |a Vogt, Tobias |e verfasserin |4 aut | |
| 700 | 1 | |a Weber, Bernd |e verfasserin |4 aut | |
| 700 | 1 | |a Kessels, Roy P C |e verfasserin |4 aut | |
| 700 | 1 | |a Schneider, Stefan |e verfasserin |4 aut | |
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