Overnight Caloric Restriction Prior to Cardiac Arrest and Resuscitation Leads to Improved Survival and Neurological Outcome in a Rodent Model
Copyright © 2021 Azadian, Tian, Bazrafkan, Maki, Rafi, Chetty, Desai, Otarola, Aguirre, Zaher, Khan, Suri, Wang, Lopour, Steward and Akbari..
While interest toward caloric restriction (CR) in various models of brain injury has increased in recent decades, studies have predominantly focused on the benefits of chronic or intermittent CR. The effects of ultra-short, including overnight, CR on acute ischemic brain injury are not well studied. Here, we show that overnight caloric restriction (75% over 14 h) prior to asphyxial cardiac arrest and resuscitation (CA) improves survival and neurological recovery as measured by, behavioral testing on neurological deficit scores, faster recovery of quantitative electroencephalography (EEG) burst suppression ratio, and complete prevention of neurodegeneration in multiple regions of the brain. We also show that overnight CR normalizes stress-induced hyperglycemia, while significantly decreasing insulin and glucagon production and increasing corticosterone and ketone body production. The benefits seen with ultra-short CR appear independent of Sirtuin 1 (SIRT-1) and brain-derived neurotrophic factor (BDNF) expression, which have been strongly linked to neuroprotective benefits seen in chronic CR. Mechanisms underlying neuroprotective effects remain to be defined, and may reveal targets for providing protection pre-CA or therapeutic interventions post-CA. These findings are also of high importance to basic sciences research as we demonstrate that minor, often-overlooked alterations to pre-experimental dietary procedures can significantly affect results, and by extension, research homogeneity and reproducibility, especially in acute ischemic brain injury models.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Frontiers in neuroscience - 14(2020) vom: 29., Seite 609670 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Azadian, Matine [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Caloric restriction |
|---|
| Anmerkungen: |
Date Revised 31.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3389/fnins.2020.609670 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM320721280 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM320721280 | ||
| 003 | DE-627 | ||
| 005 | 20240331232423.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fnins.2020.609670 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1358.xml |
| 035 | |a (DE-627)NLM320721280 | ||
| 035 | |a (NLM)33510613 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Azadian, Matine |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Overnight Caloric Restriction Prior to Cardiac Arrest and Resuscitation Leads to Improved Survival and Neurological Outcome in a Rodent Model |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 31.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2021 Azadian, Tian, Bazrafkan, Maki, Rafi, Chetty, Desai, Otarola, Aguirre, Zaher, Khan, Suri, Wang, Lopour, Steward and Akbari. | ||
| 520 | |a While interest toward caloric restriction (CR) in various models of brain injury has increased in recent decades, studies have predominantly focused on the benefits of chronic or intermittent CR. The effects of ultra-short, including overnight, CR on acute ischemic brain injury are not well studied. Here, we show that overnight caloric restriction (75% over 14 h) prior to asphyxial cardiac arrest and resuscitation (CA) improves survival and neurological recovery as measured by, behavioral testing on neurological deficit scores, faster recovery of quantitative electroencephalography (EEG) burst suppression ratio, and complete prevention of neurodegeneration in multiple regions of the brain. We also show that overnight CR normalizes stress-induced hyperglycemia, while significantly decreasing insulin and glucagon production and increasing corticosterone and ketone body production. The benefits seen with ultra-short CR appear independent of Sirtuin 1 (SIRT-1) and brain-derived neurotrophic factor (BDNF) expression, which have been strongly linked to neuroprotective benefits seen in chronic CR. Mechanisms underlying neuroprotective effects remain to be defined, and may reveal targets for providing protection pre-CA or therapeutic interventions post-CA. These findings are also of high importance to basic sciences research as we demonstrate that minor, often-overlooked alterations to pre-experimental dietary procedures can significantly affect results, and by extension, research homogeneity and reproducibility, especially in acute ischemic brain injury models | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a caloric restriction | |
| 650 | 4 | |a cardiac arrest | |
| 650 | 4 | |a cerebral ischemia | |
| 650 | 4 | |a dietary restriction | |
| 650 | 4 | |a neurological recovery | |
| 700 | 1 | |a Tian, Guilian |e verfasserin |4 aut | |
| 700 | 1 | |a Bazrafkan, Afsheen |e verfasserin |4 aut | |
| 700 | 1 | |a Maki, Niki |e verfasserin |4 aut | |
| 700 | 1 | |a Rafi, Masih |e verfasserin |4 aut | |
| 700 | 1 | |a Chetty, Nikole |e verfasserin |4 aut | |
| 700 | 1 | |a Desai, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Otarola, Ieeshiah |e verfasserin |4 aut | |
| 700 | 1 | |a Aguirre, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Zaher, Shuhab M |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Ashar |e verfasserin |4 aut | |
| 700 | 1 | |a Suri, Yusuf |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Minwei |e verfasserin |4 aut | |
| 700 | 1 | |a Lopour, Beth A |e verfasserin |4 aut | |
| 700 | 1 | |a Steward, Oswald |e verfasserin |4 aut | |
| 700 | 1 | |a Akbari, Yama |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in neuroscience |d 2007 |g 14(2020) vom: 29., Seite 609670 |w (DE-627)NLM184194563 |x 1662-4548 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2020 |g day:29 |g pages:609670 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3389/fnins.2020.609670 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2020 |b 29 |h 609670 | ||