Characteristics and outcomes of clinically diagnosed RT-PCR swab negative COVID-19 : a retrospective cohort study
Patients with strong clinical features of COVID-19 with negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and clinical relevance of this group are not well described. We performed a retrospective cohort study in two large London hospitals to characterize the demographic, clinical, and hospitalization outcome characteristics of swab-negative clinical COVID-19 patients. We found 1 in 5 patients with a negative swab and clinical suspicion of COVID-19 received a clinical diagnosis of COVID-19 within clinical documentation, discharge summary or death certificate. We compared this group to a similar swab positive cohort and found similar demographic composition, symptomology and laboratory findings. Swab-negative clinical COVID-19 patients had better outcomes, with shorter length of hospital stay, reduced need for > 60% supplementary oxygen and reduced mortality. Patients with strong clinical features of COVID-19 that are swab-negative are a common clinical challenge. Health systems must recognize and plan for the management of swab-negative patients in their COVID-19 clinical management, infection control policies and epidemiological assessments.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Scientific reports - 11(2021), 1 vom: 28. Jan., Seite 2455 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Middleton, Paul [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 25.02.2021 Date Revised 30.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-021-81930-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320717658 |
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| 500 | |a Date Revised 30.03.2024 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Patients with strong clinical features of COVID-19 with negative real time polymerase chain reaction (RT-PCR) SARS-CoV-2 testing are not currently included in official statistics. The scale, characteristics and clinical relevance of this group are not well described. We performed a retrospective cohort study in two large London hospitals to characterize the demographic, clinical, and hospitalization outcome characteristics of swab-negative clinical COVID-19 patients. We found 1 in 5 patients with a negative swab and clinical suspicion of COVID-19 received a clinical diagnosis of COVID-19 within clinical documentation, discharge summary or death certificate. We compared this group to a similar swab positive cohort and found similar demographic composition, symptomology and laboratory findings. Swab-negative clinical COVID-19 patients had better outcomes, with shorter length of hospital stay, reduced need for > 60% supplementary oxygen and reduced mortality. Patients with strong clinical features of COVID-19 that are swab-negative are a common clinical challenge. Health systems must recognize and plan for the management of swab-negative patients in their COVID-19 clinical management, infection control policies and epidemiological assessments | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Perez-Guzman, Pablo N |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Naveenta |e verfasserin |4 aut | |
| 700 | 1 | |a Kont, Mara D |e verfasserin |4 aut | |
| 700 | 1 | |a Daunt, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Mukherjee, Sujit |e verfasserin |4 aut | |
| 700 | 1 | |a Cooke, Graham |e verfasserin |4 aut | |
| 700 | 1 | |a Hallett, Timothy B |e verfasserin |4 aut | |
| 700 | 1 | |a Hauck, Katharina |e verfasserin |4 aut | |
| 700 | 1 | |a White, Peter J |e verfasserin |4 aut | |
| 700 | 1 | |a Thursz, Mark R |e verfasserin |4 aut | |
| 700 | 1 | |a Nayagam, Shevanthi |e verfasserin |4 aut | |
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