Prognostic value of VE/VCO2 slope in overweight heart failure patients
AJCD Copyright © 2020..
BACKGROUND: A decreased hypercapnic ventilatory response of the overweight patients would lower the ventilation equivalent of carbon dioxide (VE/VCO2) slope but worsen prognosis. The aim of this study was to compare the prognostic ability of the VE/VCO2 slope and peak oxygen consumption (pVO2) between normal and overweight heart failure (HF) patients.
METHODS: Prospective evaluation of ambulatory patients with reduced left ventricular ejection fraction who underwent baseline assessment with a cardiopulmonary exercise test. The primary endpoint was cardiac death or urgent heart transplantation in the 5-year period of follow-up. The predictive power of VE/VCO2 slope and pVO2 were compared (area under the curve (AUC) analysis and Hanley & McNeil test), in the subgroups of patients with body mass index (BMI) of 18.5-24.9 kg/m2 and ≥ 25 kg/m2. Statistical differences with a p value < 0.05 were considered significant.
RESULTS: There were 270 enrolled patients, with a mean BMI of 27 ± 4 kg/m2. No differences between normal and overweight patients (38.0% vs 29.8%, P=0.170) were found during the 5-year period for the primary endpoint. The VE/VCO2 slope was non-inferior to pVO2 in both groups at 1, 3 and 5 years of follow-up. The comparison of VE/VCO2 slope between groups revealed a significant lower AUC at 3 (0.921 vs 0.787, P=0.022) and 5 years (0.898 vs 0.787, P=0.044) of follow-up for overweight patients.
CONCLUSION: Despite VE/VCO2 slope provides a discriminative power at least as good as pVO2 for predicting adverse events in both normal and overweight HF patients, a significant lower predictive power was found in overweight patients.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
American journal of cardiovascular disease - 10(2020), 5 vom: 06., Seite 578-584 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Valentim Goncalves, António [VerfasserIn] |
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| Themen: |
Heart failure |
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| Anmerkungen: |
Date Revised 26.01.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320515621 |
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| 245 | 1 | 0 | |a Prognostic value of VE/VCO2 slope in overweight heart failure patients |
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| 500 | |a Date Revised 26.01.2021 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a AJCD Copyright © 2020. | ||
| 520 | |a BACKGROUND: A decreased hypercapnic ventilatory response of the overweight patients would lower the ventilation equivalent of carbon dioxide (VE/VCO2) slope but worsen prognosis. The aim of this study was to compare the prognostic ability of the VE/VCO2 slope and peak oxygen consumption (pVO2) between normal and overweight heart failure (HF) patients | ||
| 520 | |a METHODS: Prospective evaluation of ambulatory patients with reduced left ventricular ejection fraction who underwent baseline assessment with a cardiopulmonary exercise test. The primary endpoint was cardiac death or urgent heart transplantation in the 5-year period of follow-up. The predictive power of VE/VCO2 slope and pVO2 were compared (area under the curve (AUC) analysis and Hanley & McNeil test), in the subgroups of patients with body mass index (BMI) of 18.5-24.9 kg/m2 and ≥ 25 kg/m2. Statistical differences with a p value < 0.05 were considered significant | ||
| 520 | |a RESULTS: There were 270 enrolled patients, with a mean BMI of 27 ± 4 kg/m2. No differences between normal and overweight patients (38.0% vs 29.8%, P=0.170) were found during the 5-year period for the primary endpoint. The VE/VCO2 slope was non-inferior to pVO2 in both groups at 1, 3 and 5 years of follow-up. The comparison of VE/VCO2 slope between groups revealed a significant lower AUC at 3 (0.921 vs 0.787, P=0.022) and 5 years (0.898 vs 0.787, P=0.044) of follow-up for overweight patients | ||
| 520 | |a CONCLUSION: Despite VE/VCO2 slope provides a discriminative power at least as good as pVO2 for predicting adverse events in both normal and overweight HF patients, a significant lower predictive power was found in overweight patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a VE/VCO2 slope | |
| 650 | 4 | |a heart failure | |
| 650 | 4 | |a overweight | |
| 650 | 4 | |a peak O2 consumption | |
| 700 | 1 | |a Pereira-da-Silva, Tiago |e verfasserin |4 aut | |
| 700 | 1 | |a Soares, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Feliciano, Joana |e verfasserin |4 aut | |
| 700 | 1 | |a Abreu, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Rio, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Moreira, Rita Ilhao |e verfasserin |4 aut | |
| 700 | 1 | |a Cruz Ferreira, Rui |e verfasserin |4 aut | |
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