Chemically sulfated arabinoxylans from Plantago ovata seed husk : Synthesis, characterization and antiviral activity
Copyright © 2020 Elsevier Ltd. All rights reserved..
10-19:81-90; molar ratio) were produced and then characterized. According to the results, these polymers displayed anti-herpes simplex virus type 1 activity and their potency depends upon DS. The utmost effective compound (IS1203, IC50: 2.9 μg mL-1) was a 18.4 kDa arabinoxylan possessing sulfate groups at O-3 and O-2,3 positions of xylopyranosyl (Xylp), and O-5 of arabinofuranosyl (Araf) residues. Besides, this polymer showed no cytotoxicity at concentration up to 1000 μg mL-1. Given that polysaccharide sulfates have antiviral activities, synthesis of new molecules possessing diverse structures will be a useful addition to the arsenal of antivirals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:256 |
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| Enthalten in: |
Carbohydrate polymers - 256(2021) vom: 15. März, Seite 117555 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mukherjee, Shuvam [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.05.2021 Date Revised 20.05.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.carbpol.2020.117555 |
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| Förderinstitution / Projekttitel: |
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NLM320452840 |
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| 245 | 1 | 0 | |a Chemically sulfated arabinoxylans from Plantago ovata seed husk |b Synthesis, characterization and antiviral activity |
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| 520 | |a Copyright © 2020 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Limited options for the treatments of diseases triggered through viral infections revealed the quest for novel antiviral drugs. Polysaccharide sulfates owing to their unique mode of action are prominent antiviral drug candidates. Herein, the arabinoxylan of Plantago ovata seed husk was simultaneously extracted and chemically sulfated using sulphur trioxide-pyridine reagent in N,N-dimethylformamide solvent (SO3⋅Py/DMF). Thus, three arabinoxylan sulfates (IS1201-IS1203) holding variable degrees of sulfation (DS: 0.1-0.9), molar masses (18.4-31.3 kDa) and glycosyl makeup (Ara: Xyl::10-19:81-90; molar ratio) were produced and then characterized. According to the results, these polymers displayed anti-herpes simplex virus type 1 activity and their potency depends upon DS. The utmost effective compound (IS1203, IC50: 2.9 μg mL-1) was a 18.4 kDa arabinoxylan possessing sulfate groups at O-3 and O-2,3 positions of xylopyranosyl (Xylp), and O-5 of arabinofuranosyl (Araf) residues. Besides, this polymer showed no cytotoxicity at concentration up to 1000 μg mL-1. Given that polysaccharide sulfates have antiviral activities, synthesis of new molecules possessing diverse structures will be a useful addition to the arsenal of antivirals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Amalgamated extraction-sulfation process | |
| 650 | 4 | |a Anti-herpes simplex virus-1 activity | |
| 650 | 4 | |a Arabinoxylan sulfates | |
| 650 | 4 | |a Method validation | |
| 650 | 4 | |a Plantago ovata seed husk | |
| 650 | 4 | |a Structural features | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 650 | 7 | |a Glycosides |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Polysaccharides |2 NLM | |
| 650 | 7 | |a Sulfates |2 NLM | |
| 650 | 7 | |a Xylans |2 NLM | |
| 650 | 7 | |a arabinoxylan |2 NLM | |
| 650 | 7 | |a 9040-27-1 |2 NLM | |
| 700 | 1 | |a Pujol, Carlos A |e verfasserin |4 aut | |
| 700 | 1 | |a Jana, Subrata |e verfasserin |4 aut | |
| 700 | 1 | |a Damonte, Elsa B |e verfasserin |4 aut | |
| 700 | 1 | |a Ray, Bimalendu |e verfasserin |4 aut | |
| 700 | 1 | |a Ray, Sayani |e verfasserin |4 aut | |
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