Cytopathologic assessment of gloves and instruments after major head and neck surgery
Copyright © 2021 Elsevier Inc. All rights reserved..
PURPOSE: To investigate the potential for cancer cells to be transferred between anatomic sites via instruments and other materials.
MATERIALS AND METHODS: Pilot prospective study from April 2018-January 2019 at Rush University Medical Center. Glove and instrument washings were collected from 18 high-risk head and neck cancer resection cases (36 samples total). Each case maintained at least one of the following features in addition to a diagnosis of squamous cell carcinoma or sarcoma: palliative/salvage surgery, positive margins, extensive tumor burden, and/or extra capsular extension (ECE). Surgical gloves and four main instruments were placed through washings for blind cytological assessment (2 samples/case).
RESULTS: 18 patients undergoing surgical tumor resection for biopsy-proven squamous cell carcinoma with at least one of the aforementioned characteristics were included. 26.7% of cases had ECE, 40.0% had positive final margins and 46.7% had close final margins. Tumor locations included: oral cavity (10), neck (4), parotid gland (2), and skin (2). Malignant cells were isolated on glove washings in 1 case (5.5%). No malignant cells were isolated from instrument washings. The single case of malignant cells on glove washings occurred in a recurrent, invasive squamous cell carcinoma of the scalp with intracranial extension. Anucleated squamous cells likely from surgeon skin were isolated from 94.4% of washings. Squamous cells were differentiated from mature cells by the absence of nuclei.
CONCLUSIONS: Malignant squamous cells can be isolated from surgical glove washings, supporting the practice of changing of gloves after gross tumor resection during major head and neck cancer resections.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
American journal of otolaryngology - 42(2021), 3 vom: 15. Mai, Seite 102876 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kuhar, Hannah N [VerfasserIn] |
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| Links: |
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| Themen: |
Cytology |
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| Anmerkungen: |
Date Completed 13.10.2021 Date Revised 13.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.amjoto.2020.102876 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320447952 |
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| 500 | |a Date Revised 13.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: To investigate the potential for cancer cells to be transferred between anatomic sites via instruments and other materials | ||
| 520 | |a MATERIALS AND METHODS: Pilot prospective study from April 2018-January 2019 at Rush University Medical Center. Glove and instrument washings were collected from 18 high-risk head and neck cancer resection cases (36 samples total). Each case maintained at least one of the following features in addition to a diagnosis of squamous cell carcinoma or sarcoma: palliative/salvage surgery, positive margins, extensive tumor burden, and/or extra capsular extension (ECE). Surgical gloves and four main instruments were placed through washings for blind cytological assessment (2 samples/case) | ||
| 520 | |a RESULTS: 18 patients undergoing surgical tumor resection for biopsy-proven squamous cell carcinoma with at least one of the aforementioned characteristics were included. 26.7% of cases had ECE, 40.0% had positive final margins and 46.7% had close final margins. Tumor locations included: oral cavity (10), neck (4), parotid gland (2), and skin (2). Malignant cells were isolated on glove washings in 1 case (5.5%). No malignant cells were isolated from instrument washings. The single case of malignant cells on glove washings occurred in a recurrent, invasive squamous cell carcinoma of the scalp with intracranial extension. Anucleated squamous cells likely from surgeon skin were isolated from 94.4% of washings. Squamous cells were differentiated from mature cells by the absence of nuclei | ||
| 520 | |a CONCLUSIONS: Malignant squamous cells can be isolated from surgical glove washings, supporting the practice of changing of gloves after gross tumor resection during major head and neck cancer resections | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cytology | |
| 650 | 4 | |a Head and neck cancer | |
| 650 | 4 | |a Quality | |
| 650 | 4 | |a Surgical gloves | |
| 650 | 4 | |a Surgical instruments | |
| 650 | 4 | |a Tumor resection | |
| 700 | 1 | |a Shay, Aryan |e verfasserin |4 aut | |
| 700 | 1 | |a Revenaugh, Peter C |e verfasserin |4 aut | |
| 700 | 1 | |a Stenson, Kerstin |e verfasserin |4 aut | |
| 700 | 1 | |a Tajudeen, Bobby A |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Gattuso, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Khudari, Samer |e verfasserin |4 aut | |
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