Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19
The coronavirus disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the worst public health crisis in a century. However, knowledge about the dynamics of antibody responses in patients with COVID-19 is still poorly understood. In this study, we performed a serological study with serum specimens collected at the acute and the convalescent phases from 104 patients with severe COVID-19 who were part of the first wave of COVID-19 cases in Wuhan, China. Our findings revealed that neutralizing antibodies to SARS-CoV-2 are persistent for at least 6 months in patients with severe COVID-19, despite that IgG levels against the receptor binding domain (RBD) and nucleocapsid protein (N) IgG declined from the acute to the convalescent phase. Moreover, we demonstrate that the level of RBD-IgG is capable of correlating with SARS-CoV-2-neutralizing activities in COVID-19 serum. In summary, our findings identify the magnitude, functionality, and longevity of antibody responses in patients with COVID-19, which sheds light on the humoral immune response to COVID-19 and would be beneficial for developing vaccines.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
---|---|
Enthalten in: |
JCI insight - 6(2021), 4 vom: 22. Feb. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Han, Yang [VerfasserIn] |
---|
Links: |
---|
Themen: |
Adaptive immunity |
---|
Anmerkungen: |
Date Completed 08.03.2021 Date Revised 31.03.2024 published: Electronic Citation Status MEDLINE |
---|
doi: |
10.1172/jci.insight.146267 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM320386082 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM320386082 | ||
003 | DE-627 | ||
005 | 20240331232403.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1172/jci.insight.146267 |2 doi | |
028 | 5 | 2 | |a pubmed24n1358.xml |
035 | |a (DE-627)NLM320386082 | ||
035 | |a (NLM)33476301 | ||
035 | |a (PII)146267 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Han, Yang |e verfasserin |4 aut | |
245 | 1 | 0 | |a Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19 |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 08.03.2021 | ||
500 | |a Date Revised 31.03.2024 | ||
500 | |a published: Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a The coronavirus disease 19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become the worst public health crisis in a century. However, knowledge about the dynamics of antibody responses in patients with COVID-19 is still poorly understood. In this study, we performed a serological study with serum specimens collected at the acute and the convalescent phases from 104 patients with severe COVID-19 who were part of the first wave of COVID-19 cases in Wuhan, China. Our findings revealed that neutralizing antibodies to SARS-CoV-2 are persistent for at least 6 months in patients with severe COVID-19, despite that IgG levels against the receptor binding domain (RBD) and nucleocapsid protein (N) IgG declined from the acute to the convalescent phase. Moreover, we demonstrate that the level of RBD-IgG is capable of correlating with SARS-CoV-2-neutralizing activities in COVID-19 serum. In summary, our findings identify the magnitude, functionality, and longevity of antibody responses in patients with COVID-19, which sheds light on the humoral immune response to COVID-19 and would be beneficial for developing vaccines | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Adaptive immunity | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Immunoglobulins | |
650 | 7 | |a Antibodies, Neutralizing |2 NLM | |
650 | 7 | |a Antibodies, Viral |2 NLM | |
650 | 7 | |a Immune Sera |2 NLM | |
650 | 7 | |a Immunoglobulin G |2 NLM | |
700 | 1 | |a Liu, Peipei |e verfasserin |4 aut | |
700 | 1 | |a Qiu, Yang |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Jie |e verfasserin |4 aut | |
700 | 1 | |a Liu, Ying |e verfasserin |4 aut | |
700 | 1 | |a Hu, Xujuan |e verfasserin |4 aut | |
700 | 1 | |a Yang, Qingyu |e verfasserin |4 aut | |
700 | 1 | |a Huang, Rui |e verfasserin |4 aut | |
700 | 1 | |a Wen, Xinyue |e verfasserin |4 aut | |
700 | 1 | |a Song, Hao |e verfasserin |4 aut | |
700 | 1 | |a Yu, Pengcheng |e verfasserin |4 aut | |
700 | 1 | |a Yang, Mengjie |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Jing |e verfasserin |4 aut | |
700 | 1 | |a Liu, William J |e verfasserin |4 aut | |
700 | 1 | |a Peng, Ke |e verfasserin |4 aut | |
700 | 1 | |a Wu, Guizhen |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Dingyu |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Xi |e verfasserin |4 aut | |
700 | 1 | |a Wu, Ying |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t JCI insight |d 2016 |g 6(2021), 4 vom: 22. Feb. |w (DE-627)NLM257703918 |x 2379-3708 |7 nnns |
773 | 1 | 8 | |g volume:6 |g year:2021 |g number:4 |g day:22 |g month:02 |
856 | 4 | 0 | |u http://dx.doi.org/10.1172/jci.insight.146267 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 6 |j 2021 |e 4 |b 22 |c 02 |