Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer
Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Emerging microbes & infections - 10(2021), 1 vom: 20. Dez., Seite 223-225 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fevereiro, João [VerfasserIn] |
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| Links: |
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| Themen: |
BCL2L11 protein, human |
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| Anmerkungen: |
Date Completed 19.08.2021 Date Revised 21.12.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/22221751.2021.1878936 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320304035 |
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| 245 | 1 | 0 | |a Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer |
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| 520 | |a Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients | ||
| 650 | 4 | |a Letter | |
| 650 | 4 | |a Mycobacterium ulcerans | |
| 650 | 4 | |a BIM | |
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| 700 | 1 | |a Capela, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Sopoh, Ghislain E |e verfasserin |4 aut | |
| 700 | 1 | |a Dossou, Ange |e verfasserin |4 aut | |
| 700 | 1 | |a Ayelo, Gilbert Adjimon |e verfasserin |4 aut | |
| 700 | 1 | |a Peixoto, Maria João |e verfasserin |4 aut | |
| 700 | 1 | |a Cunha, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Carvalho, Agostinho |e verfasserin |4 aut | |
| 700 | 1 | |a Rodrigues, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Pedrosa, Jorge |e verfasserin |4 aut | |
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