GRADE Guidelines : 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences: Risk of bias and indirectness
Copyright © 2021. Published by Elsevier GmbH..
OBJECTIVES: The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing the risk of bias and indirectness domains for certainty of evidence about the relative importance of outcomes.
STUDY DESIGN AND SETTING: We applied the GRADE domains to rate the certainty of evidence in the importance of outcomes to several systematic reviews, iteratively reviewed draft guidance and consulted GRADE members and other stakeholders for feedback.
RESULTS: This is the first of two articles. A body of evidence addressing the importance of outcomes starts at "high certainty"; concerns with risk of bias, indirectness, inconsistency, imprecision, and publication bias lead to downgrading to moderate, low, or very low certainty. We propose the following subdomains of risk of bias: selection of the study population, missing data, the type of measurement instrument, and confounding; we have developed items for each subdomain. The population, intervention, comparison, and outcome elements associated with the evidence determine the degree of indirectness.
CONCLUSION: This article provides guidance and examples for rating the risk of bias and indirectness for a body of evidence summarizing the importance of outcomes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:160 |
|---|---|
| Enthalten in: |
Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - 160(2021) vom: 15. Feb., Seite 78-88 |
| Sprache: |
Deutsch |
|---|
| Weiterer Titel: |
GRADE-Leitlinien: 19. Bewertung der Vertrauenswürdigkeit der Evidenz für die Bedeutung von Endpunkten oder Werten und Präferenzen – Risiko für Bias und Indirektheit |
|---|
| Beteiligte Personen: |
Kaiser, Laura [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 18.02.2021 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.zefq.2020.11.004 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM320244342 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM320244342 | ||
| 003 | DE-627 | ||
| 005 | 20231225173149.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.1016/j.zefq.2020.11.004 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1067.xml |
| 035 | |a (DE-627)NLM320244342 | ||
| 035 | |a (NLM)33461905 | ||
| 035 | |a (PII)S1865-9217(20)30177-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a ger | ||
| 100 | 1 | |a Kaiser, Laura |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a GRADE Guidelines |b 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences: Risk of bias and indirectness |
| 246 | 3 | 3 | |a GRADE-Leitlinien: 19. Bewertung der Vertrauenswürdigkeit der Evidenz für die Bedeutung von Endpunkten oder Werten und Präferenzen – Risiko für Bias und Indirektheit |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.02.2021 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier GmbH. | ||
| 520 | |a OBJECTIVES: The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group defines patient values and preferences as the relative importance patients place on the main health outcomes. We provide GRADE guidance for assessing the risk of bias and indirectness domains for certainty of evidence about the relative importance of outcomes | ||
| 520 | |a STUDY DESIGN AND SETTING: We applied the GRADE domains to rate the certainty of evidence in the importance of outcomes to several systematic reviews, iteratively reviewed draft guidance and consulted GRADE members and other stakeholders for feedback | ||
| 520 | |a RESULTS: This is the first of two articles. A body of evidence addressing the importance of outcomes starts at "high certainty"; concerns with risk of bias, indirectness, inconsistency, imprecision, and publication bias lead to downgrading to moderate, low, or very low certainty. We propose the following subdomains of risk of bias: selection of the study population, missing data, the type of measurement instrument, and confounding; we have developed items for each subdomain. The population, intervention, comparison, and outcome elements associated with the evidence determine the degree of indirectness | ||
| 520 | |a CONCLUSION: This article provides guidance and examples for rating the risk of bias and indirectness for a body of evidence summarizing the importance of outcomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bedeutung von Endpunkten | |
| 650 | 4 | |a GRADE | |
| 650 | 4 | |a Importance of outcomes | |
| 650 | 4 | |a Indirectness | |
| 650 | 4 | |a Indirektheit | |
| 650 | 4 | |a Quality of evidence | |
| 650 | 4 | |a Qualität der Evidenz | |
| 650 | 4 | |a Risiko für Bias | |
| 650 | 4 | |a Risk of bias | |
| 650 | 4 | |a Value and preference | |
| 650 | 4 | |a Werte und Präferenzen | |
| 700 | 1 | |a Hübscher, Markus |e verfasserin |4 aut | |
| 700 | 1 | |a Rissling, Olesja |e verfasserin |4 aut | |
| 700 | 1 | |a Schulz, Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Langer, Gero |e verfasserin |4 aut | |
| 700 | 1 | |a Meerpohl, Jörg |e verfasserin |4 aut | |
| 700 | 1 | |a Schwingshackl, Lukas |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen |d 2008 |g 160(2021) vom: 15. Feb., Seite 78-88 |w (DE-627)NLM184447119 |x 2212-0289 |7 nnns |
| 773 | 1 | 8 | |g volume:160 |g year:2021 |g day:15 |g month:02 |g pages:78-88 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.zefq.2020.11.004 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 160 |j 2021 |b 15 |c 02 |h 78-88 | ||