Validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in Internal Medicine wards; a prospective, multicenter study
Copyright © 2021. Published by Elsevier B.V..
BACKGROUND: Few data are available on the validity of "Sepsis-3" criteria in identifying patients with sepsis in internal medicine wards (IMWs). Real-life data about this topic and on the prevalence of sepsis in IMWs could be useful for improving hospital organization.
OBJECTIVES: To assess the validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in IMWs. Secondary objectives: to evaluate the prevalence of these patients in IMWs and to compare "Sepsis-3" and "Sepsis-1" criteria.
METHODS: Multicenter, prospective, observational, cohort study, carried out in 22 IMWs of Tuscany (Italy). All patients admitted to each of the study centers over a period of 21-31 days were evaluated within 48 hours; those with clinical signs of infection were enrolled. The main outcome was in-hospital mortality.
RESULTS: 2,839 patients were evaluated and 938 (33%) met the inclusion criteria. Patients with sepsis diagnosed according to "Sepsis-3" were 522, representing 55.6% of patients with infection and 18.4% of all patients hospitalized; they were older than those without sepsis (79.4±12.5 vs 74.6±15.2 years, p<0.001). In-hospital mortality was significantly higher in patients with sepsis compared to others (13.8% vs 4.6%; p<0.001). "Sepsis-3" criteria showed greater predictive validity for in-hospital mortality than "Sepsis-1" criteria (AUROC=0.71; 95%CI, 0.66-0.77 vs 0.60; 95%CI 0.54-0.66; p=0.0038).
CONCLUSIONS: "Sepsis-3" criteria are able to identify patients with community-onset sepsis in IMWs, whose prevalence and in-hospital mortality are remarkably high. Medical departments should adapt their organization to the needs for care of these complex patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
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| Enthalten in: |
European journal of internal medicine - 85(2021) vom: 01. März, Seite 92-97 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fortini, Alberto [VerfasserIn] |
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| Links: |
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| Themen: |
In-hospital mortality |
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| Anmerkungen: |
Date Completed 23.04.2021 Date Revised 23.04.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejim.2020.12.025 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM320147347 |
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| 100 | 1 | |a Fortini, Alberto |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in Internal Medicine wards; a prospective, multicenter study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 23.04.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier B.V. | ||
| 520 | |a BACKGROUND: Few data are available on the validity of "Sepsis-3" criteria in identifying patients with sepsis in internal medicine wards (IMWs). Real-life data about this topic and on the prevalence of sepsis in IMWs could be useful for improving hospital organization | ||
| 520 | |a OBJECTIVES: To assess the validity of "Sepsis-3" criteria in identifying patients with community-onset sepsis in IMWs. Secondary objectives: to evaluate the prevalence of these patients in IMWs and to compare "Sepsis-3" and "Sepsis-1" criteria | ||
| 520 | |a METHODS: Multicenter, prospective, observational, cohort study, carried out in 22 IMWs of Tuscany (Italy). All patients admitted to each of the study centers over a period of 21-31 days were evaluated within 48 hours; those with clinical signs of infection were enrolled. The main outcome was in-hospital mortality | ||
| 520 | |a RESULTS: 2,839 patients were evaluated and 938 (33%) met the inclusion criteria. Patients with sepsis diagnosed according to "Sepsis-3" were 522, representing 55.6% of patients with infection and 18.4% of all patients hospitalized; they were older than those without sepsis (79.4±12.5 vs 74.6±15.2 years, p<0.001). In-hospital mortality was significantly higher in patients with sepsis compared to others (13.8% vs 4.6%; p<0.001). "Sepsis-3" criteria showed greater predictive validity for in-hospital mortality than "Sepsis-1" criteria (AUROC=0.71; 95%CI, 0.66-0.77 vs 0.60; 95%CI 0.54-0.66; p=0.0038) | ||
| 520 | |a CONCLUSIONS: "Sepsis-3" criteria are able to identify patients with community-onset sepsis in IMWs, whose prevalence and in-hospital mortality are remarkably high. Medical departments should adapt their organization to the needs for care of these complex patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Sepsis | |
| 650 | 4 | |a in-hospital mortality | |
| 650 | 4 | |a internal medicine | |
| 700 | 1 | |a Faraone, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Meini, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Bettucchi, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Longo, Benedetta |e verfasserin |4 aut | |
| 700 | 1 | |a Valoriani, Beatrice |e verfasserin |4 aut | |
| 700 | 1 | |a Forni, Silvia |e verfasserin |4 aut | |
| 700 | 0 | |a Italian Federation of Hospital Internists (FADOI) - Sepsis Collaboration Group of the Tuscany Region |e verfasserin |4 aut | |
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