Risk factors for mortality and progression to severe COVID-19 disease in the Southeast region in the United States : A report from the SEUS Study Group
OBJECTIVE: Identify risk factors that could increase progression to severe disease and mortality in hospitalized SARS-CoV-2 patients in the Southeast region of the United States.
DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective cohort including 502 adults hospitalized with laboratory-confirmed COVID-19 between March 1, 2020, and May 8, 2020 within 1 of 15 participating hospitals in 5 health systems across 5 states in the Southeast United States.
METHODS: The study objectives were to identify risk factors that could increase progression to hospital mortality and severe disease (defined as a composite of intensive care unit admission or requirement of mechanical ventilation) in hospitalized SARS-CoV-2 patients in the Southeast United States.
RESULTS: In total, 502 patients were included, and 476 of 502 (95%) had clinically evaluable outcomes. The hospital mortality rate was 16% (76 of 476); 35% (177 of 502) required ICU admission and 18% (91 of 502) required mechanical ventilation. By both univariate and adjusted multivariate analyses, hospital mortality was independently associated with age (adjusted odds ratio [aOR], 2.03 for each decade increase; 95% confidence interval [CI], 1.56--2.69), male sex (aOR, 2.44; 95% CI, 1.34-4.59), and cardiovascular disease (aOR, 2.16; 95% CI, 1.15-4.09). As with mortality, risk of severe disease was independently associated with age (aOR, 1.17 for each decade increase; 95% CI, 1.00-1.37), male sex (aOR, 2.34; 95% CI, 1.54-3.60), and cardiovascular disease (aOR, 1.77; 95% CI, 1.09-2.85).
CONCLUSIONS: In an adjusted multivariate analysis, advanced age, male sex, and cardiovascular disease increased risk of severe disease and mortality in patients with COVID-19 in the Southeast United States. In-hospital mortality risk doubled with each subsequent decade of life.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Infection control and hospital epidemiology - 42(2021), 12 vom: 28. Dez., Seite 1464-1472 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hobbs, Athena L V [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.12.2021 Date Revised 24.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1017/ice.2020.1435 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM319906450 |
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| 100 | 1 | |a Hobbs, Athena L V |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk factors for mortality and progression to severe COVID-19 disease in the Southeast region in the United States |b A report from the SEUS Study Group |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: Identify risk factors that could increase progression to severe disease and mortality in hospitalized SARS-CoV-2 patients in the Southeast region of the United States | ||
| 520 | |a DESIGN, SETTING, AND PARTICIPANTS: Multicenter, retrospective cohort including 502 adults hospitalized with laboratory-confirmed COVID-19 between March 1, 2020, and May 8, 2020 within 1 of 15 participating hospitals in 5 health systems across 5 states in the Southeast United States | ||
| 520 | |a METHODS: The study objectives were to identify risk factors that could increase progression to hospital mortality and severe disease (defined as a composite of intensive care unit admission or requirement of mechanical ventilation) in hospitalized SARS-CoV-2 patients in the Southeast United States | ||
| 520 | |a RESULTS: In total, 502 patients were included, and 476 of 502 (95%) had clinically evaluable outcomes. The hospital mortality rate was 16% (76 of 476); 35% (177 of 502) required ICU admission and 18% (91 of 502) required mechanical ventilation. By both univariate and adjusted multivariate analyses, hospital mortality was independently associated with age (adjusted odds ratio [aOR], 2.03 for each decade increase; 95% confidence interval [CI], 1.56--2.69), male sex (aOR, 2.44; 95% CI, 1.34-4.59), and cardiovascular disease (aOR, 2.16; 95% CI, 1.15-4.09). As with mortality, risk of severe disease was independently associated with age (aOR, 1.17 for each decade increase; 95% CI, 1.00-1.37), male sex (aOR, 2.34; 95% CI, 1.54-3.60), and cardiovascular disease (aOR, 1.77; 95% CI, 1.09-2.85) | ||
| 520 | |a CONCLUSIONS: In an adjusted multivariate analysis, advanced age, male sex, and cardiovascular disease increased risk of severe disease and mortality in patients with COVID-19 in the Southeast United States. In-hospital mortality risk doubled with each subsequent decade of life | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 700 | 1 | |a Turner, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Omer, Imad |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Morgan K |e verfasserin |4 aut | |
| 700 | 1 | |a Beaulieu, Ronald M |e verfasserin |4 aut | |
| 700 | 1 | |a Sheikh, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Spires, S Shaefer |e verfasserin |4 aut | |
| 700 | 1 | |a Fiske, Christina T |e verfasserin |4 aut | |
| 700 | 1 | |a Dare, Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Goorha, Salil |e verfasserin |4 aut | |
| 700 | 1 | |a Thapa, Priyenka |e verfasserin |4 aut | |
| 700 | 1 | |a Gnann, John |e verfasserin |4 aut | |
| 700 | 1 | |a Wright, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Nelson, George E |e verfasserin |4 aut | |
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