Measuring functional connectivity in patients with strabismus using stationary functional magnetic resonance imaging : a resting-state network study
BACKGROUND: Strabismus (STR) is a common eye disease characterized by abnormal eye movements and stereo vision. Neuroimaging studies have revealed that STR patients have impaired functional connectivity (FC) in the visual cortex and sensorimotor cortex.
PURPOSE: To investigate alterations in FC and connections within and between subnetworks of the visual network (VN), sensorimotor network (SMN), and default mode network (DMN) in patients with STR.
MATERIAL AND METHODS: A total of 32 patients with STR (24 men, 8 women) and 32 age- and sex-matched healthy controls (HCs) (24 men, 8 women) were recruited. Participants underwent resting-state functional magnetic resonance imaging scans. The resting-state network (RSN) was examined by independent component analysis, and differences in RSN FC between STR and HC groups were evaluated with the t test. Functional network connectivity (FNC) analysis was performed for the three RSNs.
RESULTS: Compared to the HC group, the STR group showed increased FC in the VN and SMN (voxel-level P < 0.01; two-tailed Gaussian random field correction; cluster-level P < 0.05). There were no significant alterations in DMN FC between the two groups. FNC analysis of connections in the RSN revealed that one of the three connections in the VN was reduced, but no connectivity changes were observed in the SMN or DMN. FNC analysis of the connection between two RSNs showed that two had increased and one had a decreased connection value.
CONCLUSION: The VN, SMN, and DMN are reorganized in patients with STR compared to HCs, providing novel insight into the neural substrates of STR.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:63 |
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| Enthalten in: |
Acta radiologica (Stockholm, Sweden : 1987) - 63(2022), 1 vom: 03. Jan., Seite 110-121 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yu, Kang [VerfasserIn] |
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| Links: |
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| Themen: |
Functional connectivity |
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| Anmerkungen: |
Date Completed 17.12.2021 Date Revised 17.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/0284185120983978 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319870480 |
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| 100 | 1 | |a Yu, Kang |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Measuring functional connectivity in patients with strabismus using stationary functional magnetic resonance imaging |b a resting-state network study |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 17.12.2021 | ||
| 500 | |a Date Revised 17.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Strabismus (STR) is a common eye disease characterized by abnormal eye movements and stereo vision. Neuroimaging studies have revealed that STR patients have impaired functional connectivity (FC) in the visual cortex and sensorimotor cortex | ||
| 520 | |a PURPOSE: To investigate alterations in FC and connections within and between subnetworks of the visual network (VN), sensorimotor network (SMN), and default mode network (DMN) in patients with STR | ||
| 520 | |a MATERIAL AND METHODS: A total of 32 patients with STR (24 men, 8 women) and 32 age- and sex-matched healthy controls (HCs) (24 men, 8 women) were recruited. Participants underwent resting-state functional magnetic resonance imaging scans. The resting-state network (RSN) was examined by independent component analysis, and differences in RSN FC between STR and HC groups were evaluated with the t test. Functional network connectivity (FNC) analysis was performed for the three RSNs | ||
| 520 | |a RESULTS: Compared to the HC group, the STR group showed increased FC in the VN and SMN (voxel-level P < 0.01; two-tailed Gaussian random field correction; cluster-level P < 0.05). There were no significant alterations in DMN FC between the two groups. FNC analysis of connections in the RSN revealed that one of the three connections in the VN was reduced, but no connectivity changes were observed in the SMN or DMN. FNC analysis of the connection between two RSNs showed that two had increased and one had a decreased connection value | ||
| 520 | |a CONCLUSION: The VN, SMN, and DMN are reorganized in patients with STR compared to HCs, providing novel insight into the neural substrates of STR | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Strabismus | |
| 650 | 4 | |a functional connectivity | |
| 650 | 4 | |a independent component analysis | |
| 650 | 4 | |a resting-state network | |
| 700 | 1 | |a Lin, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Ge, Qian-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Chen-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Qiu-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Yi-Cong |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Yi |e verfasserin |4 aut | |
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