Metabolic Profiling of Praziquantel-mediated Prevention of Opisthorchis viverrini-induced Cholangiocyte Transformation in the Hamster Model of Cholangiocarcinoma
Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved..
BACKGROUND: Opisthorchis viverrini (Ov) infection-induced cholangiocarcinoma (CCA) is a major public health problem in northeastern Thailand. Praziquantel was shown to prevent CCA development in an Ov-infected hamster model; however, the molecular mechanism remains unknown.
MATERIALS AND METHODS: In this study, we used a hamster model with Ov and N-nitrosodimethylamine-induced CCA to study the mechanisms of praziquantel action. The liver tissues from the hamsters with and without praziquantel treatment were analyzed using 1H nuclear magnetic resonance spectroscopy.
RESULTS: A total of 14 metabolites were found to be significantly different between the two groups. Furthermore, the combination of acetate, inosine and sarcosine was shown to exert an anti-inflammatory effect through interleukin-6 inhibition in a macrophage cell line, suggesting a mechanism by which praziquantel may prevent inflammation caused by Ov, cholangiocyte transformation and further CCA develpoment.
CONCLUSION: These findings might avail the development of a preventive strategy for CCA in high-risk populations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Cancer genomics & proteomics - 18(2021), 1 vom: 08. Jan., Seite 29-42 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Prommajun, Pattama [VerfasserIn] |
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| Links: |
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| Themen: |
6490C9U457 |
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| Anmerkungen: |
Date Completed 20.08.2021 Date Revised 10.02.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.21873/cgp.20239 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM319834956 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | ||
| 520 | |a BACKGROUND: Opisthorchis viverrini (Ov) infection-induced cholangiocarcinoma (CCA) is a major public health problem in northeastern Thailand. Praziquantel was shown to prevent CCA development in an Ov-infected hamster model; however, the molecular mechanism remains unknown | ||
| 520 | |a MATERIALS AND METHODS: In this study, we used a hamster model with Ov and N-nitrosodimethylamine-induced CCA to study the mechanisms of praziquantel action. The liver tissues from the hamsters with and without praziquantel treatment were analyzed using 1H nuclear magnetic resonance spectroscopy | ||
| 520 | |a RESULTS: A total of 14 metabolites were found to be significantly different between the two groups. Furthermore, the combination of acetate, inosine and sarcosine was shown to exert an anti-inflammatory effect through interleukin-6 inhibition in a macrophage cell line, suggesting a mechanism by which praziquantel may prevent inflammation caused by Ov, cholangiocyte transformation and further CCA develpoment | ||
| 520 | |a CONCLUSION: These findings might avail the development of a preventive strategy for CCA in high-risk populations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Praziquantel | |
| 650 | 4 | |a anti-inflammation | |
| 650 | 4 | |a cholangiocarcinoma | |
| 650 | 4 | |a metabolic profiling | |
| 650 | 4 | |a nuclear magnetic resonance spectroscopy. | |
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| 650 | 7 | |a Praziquantel |2 NLM | |
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