Dissecting the clinical heterogeneity of adult-onset Still's disease : results from a multi-dimensional characterization and stratification
© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com..
OBJECTIVES: To stratify adult-onset Still's disease (AOSD) patients in distinct clinical subsets to be differently managed, by using a multi-dimensional characterization.
METHODS: AOSD patients were evaluated by using a hierarchical unsupervised cluster analysis comprising age, laboratory markers systemic score and outcomes. The squared Euclidean distances between each pair of patients were calculated and put into a distance matrix, which served as the input clustering algorithm. Derived clusters were descriptively analysed for any possible difference.
RESULTS: Four AOSD patients clusters were identified. Disease onset in cluster 1 was characterized by fever (100%), skin rash (92%) and arthritis (83%), with the highest ferritin levels [mean (S.D.) 14 724 (6837) ng/ml]. In cluster 2, the onset was characterized by fever (100%), arthritis (100%) and liver involvement (90%), together with the highest CRP levels [288.10 (46.01) mg/l]. The patients in cluster 3 presented with fever (100%), myalgia (96%) and sore throat (92%). The highest systemic score values [8.88 (1.70)] and the highest mortality rate (54.2%) defined cluster 3. Fever (100%) and arthritis (90%) were the symptoms at the onset in cluster 4, which was characterized by the lowest ferritin and CRP levels [1457 (1298) ng/ml and 54.98 (48.67) mg/l, respectively].
CONCLUSION: Four distinct phenotypic subgroups in AOSD could be suggested, possibly associated with different genetic background and pathogenic mechanisms. Our results could provide the basis for a precision medicine approach in AOSD in an attempt to find a clinical and laboratory multidimensional stratification and characterization, which would drive a tailored therapeutic approach in these patients.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
---|---|
Enthalten in: |
Rheumatology (Oxford, England) - 60(2021), 10 vom: 02. Okt., Seite 4844-4849 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Berardicurti, Onorina [VerfasserIn] |
---|
Links: |
---|
Themen: |
9007-41-4 |
---|
Anmerkungen: |
Date Completed 29.12.2021 Date Revised 29.12.2021 published: Print Citation Status MEDLINE |
---|
doi: |
10.1093/rheumatology/keaa904 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM319684377 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM319684377 | ||
003 | DE-627 | ||
005 | 20231225171954.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1093/rheumatology/keaa904 |2 doi | |
028 | 5 | 2 | |a pubmed24n1065.xml |
035 | |a (DE-627)NLM319684377 | ||
035 | |a (NLM)33404641 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Berardicurti, Onorina |e verfasserin |4 aut | |
245 | 1 | 0 | |a Dissecting the clinical heterogeneity of adult-onset Still's disease |b results from a multi-dimensional characterization and stratification |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 29.12.2021 | ||
500 | |a Date Revised 29.12.2021 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
520 | |a OBJECTIVES: To stratify adult-onset Still's disease (AOSD) patients in distinct clinical subsets to be differently managed, by using a multi-dimensional characterization | ||
520 | |a METHODS: AOSD patients were evaluated by using a hierarchical unsupervised cluster analysis comprising age, laboratory markers systemic score and outcomes. The squared Euclidean distances between each pair of patients were calculated and put into a distance matrix, which served as the input clustering algorithm. Derived clusters were descriptively analysed for any possible difference | ||
520 | |a RESULTS: Four AOSD patients clusters were identified. Disease onset in cluster 1 was characterized by fever (100%), skin rash (92%) and arthritis (83%), with the highest ferritin levels [mean (S.D.) 14 724 (6837) ng/ml]. In cluster 2, the onset was characterized by fever (100%), arthritis (100%) and liver involvement (90%), together with the highest CRP levels [288.10 (46.01) mg/l]. The patients in cluster 3 presented with fever (100%), myalgia (96%) and sore throat (92%). The highest systemic score values [8.88 (1.70)] and the highest mortality rate (54.2%) defined cluster 3. Fever (100%) and arthritis (90%) were the symptoms at the onset in cluster 4, which was characterized by the lowest ferritin and CRP levels [1457 (1298) ng/ml and 54.98 (48.67) mg/l, respectively] | ||
520 | |a CONCLUSION: Four distinct phenotypic subgroups in AOSD could be suggested, possibly associated with different genetic background and pathogenic mechanisms. Our results could provide the basis for a precision medicine approach in AOSD in an attempt to find a clinical and laboratory multidimensional stratification and characterization, which would drive a tailored therapeutic approach in these patients | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a adult-onset Still’s disease | |
650 | 4 | |a precision medicine | |
650 | 7 | |a Biomarkers |2 NLM | |
650 | 7 | |a C-Reactive Protein |2 NLM | |
650 | 7 | |a 9007-41-4 |2 NLM | |
650 | 7 | |a Ferritins |2 NLM | |
650 | 7 | |a 9007-73-2 |2 NLM | |
700 | 1 | |a Conforti, Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Iacono, Daniela |e verfasserin |4 aut | |
700 | 1 | |a Pantano, Ilenia |e verfasserin |4 aut | |
700 | 1 | |a Caso, Francesco |e verfasserin |4 aut | |
700 | 1 | |a Emmi, Giacomo |e verfasserin |4 aut | |
700 | 1 | |a Grembiale, Rosa Daniela |e verfasserin |4 aut | |
700 | 1 | |a Cantatore, Francesco Paolo |e verfasserin |4 aut | |
700 | 1 | |a Atzeni, Fabiola |e verfasserin |4 aut | |
700 | 1 | |a Perosa, Federico |e verfasserin |4 aut | |
700 | 1 | |a Scarpa, Raffaele |e verfasserin |4 aut | |
700 | 1 | |a Guggino, Giuliana |e verfasserin |4 aut | |
700 | 1 | |a Ciccia, Francesco |e verfasserin |4 aut | |
700 | 1 | |a Giacomelli, Roberto |e verfasserin |4 aut | |
700 | 1 | |a Cipriani, Paola |e verfasserin |4 aut | |
700 | 1 | |a Ruscitti, Piero |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Rheumatology (Oxford, England) |d 1999 |g 60(2021), 10 vom: 02. Okt., Seite 4844-4849 |w (DE-627)NLM102581908 |x 1462-0332 |7 nnns |
773 | 1 | 8 | |g volume:60 |g year:2021 |g number:10 |g day:02 |g month:10 |g pages:4844-4849 |
856 | 4 | 0 | |u http://dx.doi.org/10.1093/rheumatology/keaa904 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 60 |j 2021 |e 10 |b 02 |c 10 |h 4844-4849 |