Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Molecular brain - 14(2021), 1 vom: 05. Jan., Seite 1 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Choi, Dong Il [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
CCCTC-Binding Factor |
|---|
| Anmerkungen: |
Date Completed 01.09.2021 Date Revised 26.02.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1186/s13041-020-00716-z |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM319660311 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM319660311 | ||
| 003 | DE-627 | ||
| 005 | 20240229152520.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13041-020-00716-z |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1306.xml |
| 035 | |a (DE-627)NLM319660311 | ||
| 035 | |a (NLM)33402211 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Choi, Dong Il |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.09.2021 | ||
| 500 | |a Date Revised 26.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a CCCTC-Binding Factor |2 NLM | |
| 650 | 7 | |a Ctcf protein, mouse |2 NLM | |
| 700 | 1 | |a Kim, Myeongwon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Somi |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Nam-Kyung |e verfasserin |4 aut | |
| 700 | 1 | |a Kwak, Chuljung |e verfasserin |4 aut | |
| 700 | 1 | |a Seo, Hyunhyo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Kyungmin |e verfasserin |4 aut | |
| 700 | 1 | |a Kaang, Bong-Kiun |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular brain |d 2008 |g 14(2021), 1 vom: 05. Jan., Seite 1 |w (DE-627)NLM182539938 |x 1756-6606 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2021 |g number:1 |g day:05 |g month:01 |g pages:1 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s13041-020-00716-z |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2021 |e 1 |b 05 |c 01 |h 1 | ||