Hypokalemia in Patients with COVID-19
BACKGROUND: Patients with COVID-19 experience multiple clinical conditions that may cause electrolyte imbalances. Hypokalemia is a concerning electrolyte disorder closely associated with severe complications. This study aimed to estimate prevalence, risk factors and outcome of hypokalemia in a cohort of patients with confirmed COVID-19.
METHODS: A retrospective analysis was conducted on 290 non-ICU admitted patients with COVID-19 at the tertiary teaching hospital of Modena, Italy, from February 16 to April 14, 2020.
RESULTS: Hypokalemia was detected in 119 out of 290 patients (41%) during hospitalization. Mean serum potassium was 3.1 ± 0.1 meq/L. The majority of patients (90.7%) patients experienced only a mild decrease in serum potassium level (3-3.4 mEq/L). Hypokalemia was associated with hypocalcemia, which was detected in 50% of subjects. Urine potassium-to-creatinine ratio, measured in a small number of patients (n = 45; 36.1%), revealed an increase of urinary potassium excretion in most cases (95.5%). Risk factors for hypokalemia were female sex (odds ratio (OR) 2.44; 95% CI 1.36-4.37; P 0.003) and diuretic therapy (OR 1.94, 95% CI 1.08-3.48; P 0.027). Hypokalemia, adjusted for sex, age and SOFA score, was not associated with ICU transfer (OR 0.52; 95% CI 0.228-1.212; P = 0.131), in-hospital mortality (OR, 0.47; 95% CI 0.170-1.324; P = 0.154) and composite outcome of ICU transfer or in-hospital mortality (OR 0.48; 95% CI 0.222-1.047; P = 0.065) in our cohort of patients.
CONCLUSIONS: Hypokalemia was a frequent disorder in subjects with COVID-19. Female sex and diuretic therapy were identified as risk factors for low serum potassium levels. Hypokalemia was unrelated to ICU transfer and death in this cohort of patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
|---|---|
| Enthalten in: |
Clinical and experimental nephrology - 25(2021), 4 vom: 04. Apr., Seite 401-409 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Alfano, Gaetano [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COVID |
|---|
| Anmerkungen: |
Date Completed 23.03.2021 Date Revised 16.07.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10157-020-01996-4 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM319625109 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM319625109 | ||
| 003 | DE-627 | ||
| 005 | 20231225171840.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10157-020-01996-4 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1065.xml |
| 035 | |a (DE-627)NLM319625109 | ||
| 035 | |a (NLM)33398605 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Alfano, Gaetano |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hypokalemia in Patients with COVID-19 |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.03.2021 | ||
| 500 | |a Date Revised 16.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Patients with COVID-19 experience multiple clinical conditions that may cause electrolyte imbalances. Hypokalemia is a concerning electrolyte disorder closely associated with severe complications. This study aimed to estimate prevalence, risk factors and outcome of hypokalemia in a cohort of patients with confirmed COVID-19 | ||
| 520 | |a METHODS: A retrospective analysis was conducted on 290 non-ICU admitted patients with COVID-19 at the tertiary teaching hospital of Modena, Italy, from February 16 to April 14, 2020 | ||
| 520 | |a RESULTS: Hypokalemia was detected in 119 out of 290 patients (41%) during hospitalization. Mean serum potassium was 3.1 ± 0.1 meq/L. The majority of patients (90.7%) patients experienced only a mild decrease in serum potassium level (3-3.4 mEq/L). Hypokalemia was associated with hypocalcemia, which was detected in 50% of subjects. Urine potassium-to-creatinine ratio, measured in a small number of patients (n = 45; 36.1%), revealed an increase of urinary potassium excretion in most cases (95.5%). Risk factors for hypokalemia were female sex (odds ratio (OR) 2.44; 95% CI 1.36-4.37; P 0.003) and diuretic therapy (OR 1.94, 95% CI 1.08-3.48; P 0.027). Hypokalemia, adjusted for sex, age and SOFA score, was not associated with ICU transfer (OR 0.52; 95% CI 0.228-1.212; P = 0.131), in-hospital mortality (OR, 0.47; 95% CI 0.170-1.324; P = 0.154) and composite outcome of ICU transfer or in-hospital mortality (OR 0.48; 95% CI 0.222-1.047; P = 0.065) in our cohort of patients | ||
| 520 | |a CONCLUSIONS: Hypokalemia was a frequent disorder in subjects with COVID-19. Female sex and diuretic therapy were identified as risk factors for low serum potassium levels. Hypokalemia was unrelated to ICU transfer and death in this cohort of patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a COVID | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Electrolytes | |
| 650 | 4 | |a Hypokalemia | |
| 650 | 4 | |a Magnesium | |
| 650 | 4 | |a Potassium | |
| 650 | 7 | |a Diuretics |2 NLM | |
| 650 | 7 | |a Potassium |2 NLM | |
| 650 | 7 | |a RWP5GA015D |2 NLM | |
| 700 | 1 | |a Ferrari, Annachiara |e verfasserin |4 aut | |
| 700 | 1 | |a Fontana, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Perrone, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Mori, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Ascione, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Magistroni, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Venturi, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Pederzoli, Simone |e verfasserin |4 aut | |
| 700 | 1 | |a Margiotta, Gianluca |e verfasserin |4 aut | |
| 700 | 1 | |a Romeo, Marilina |e verfasserin |4 aut | |
| 700 | 1 | |a Piccinini, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Franceschi, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Volpi, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Faltoni, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Ciusa, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Bacca, Erica |e verfasserin |4 aut | |
| 700 | 1 | |a Tutone, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Raimondi, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Menozzi, Marianna |e verfasserin |4 aut | |
| 700 | 1 | |a Franceschini, Erica |e verfasserin |4 aut | |
| 700 | 1 | |a Cuomo, Gianluca |e verfasserin |4 aut | |
| 700 | 1 | |a Orlando, Gabriella |e verfasserin |4 aut | |
| 700 | 1 | |a Santoro, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Di Gaetano, Margherita |e verfasserin |4 aut | |
| 700 | 1 | |a Puzzolante, Cinzia |e verfasserin |4 aut | |
| 700 | 1 | |a Carli, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Bedini, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Milic, Jovana |e verfasserin |4 aut | |
| 700 | 1 | |a Meschiari, Marianna |e verfasserin |4 aut | |
| 700 | 1 | |a Mussini, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Cappelli, Gianni |e verfasserin |4 aut | |
| 700 | 1 | |a Guaraldi, Giovanni |e verfasserin |4 aut | |
| 700 | 0 | |a Modena Covid-19 Working Group (MoCo19) |e verfasserin |4 aut | |
| 700 | 1 | |a Mussini, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Guaraldi, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Bacca, Erica |e investigator |4 oth | |
| 700 | 1 | |a Bedini, Andrea |e investigator |4 oth | |
| 700 | 1 | |a Borghi, Vanni |e investigator |4 oth | |
| 700 | 1 | |a Burastero, Giulia |e investigator |4 oth | |
| 700 | 1 | |a Carli, Federica |e investigator |4 oth | |
| 700 | 1 | |a Ciusa, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Corradi, Luca |e investigator |4 oth | |
| 700 | 1 | |a Cuomo, Gianluca |e investigator |4 oth | |
| 700 | 1 | |a Di Gaetano, Margherita |e investigator |4 oth | |
| 700 | 1 | |a Dolci, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Faltoni, Matteo |e investigator |4 oth | |
| 700 | 1 | |a Fantini, Riccardo |e investigator |4 oth | |
| 700 | 1 | |a Franceschi, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Franceschini, Erica |e investigator |4 oth | |
| 700 | 1 | |a Iadisernia, Vittorio |e investigator |4 oth | |
| 700 | 1 | |a Larné, Damiano |e investigator |4 oth | |
| 700 | 1 | |a Menozzi, Marianna |e investigator |4 oth | |
| 700 | 1 | |a Meschiari, Marianna |e investigator |4 oth | |
| 700 | 1 | |a Milic, Jovana |e investigator |4 oth | |
| 700 | 1 | |a Orlando, Gabriella |e investigator |4 oth | |
| 700 | 1 | |a Pellegrino, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Raimondi, Alessandro |e investigator |4 oth | |
| 700 | 1 | |a Rogati, Carlotta |e investigator |4 oth | |
| 700 | 1 | |a Santoro, Antonella |e investigator |4 oth | |
| 700 | 1 | |a Tonelli, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Tutone, Marco |e investigator |4 oth | |
| 700 | 1 | |a Volpi, Sara |e investigator |4 oth | |
| 700 | 1 | |a Yaacoub, Dina |e investigator |4 oth | |
| 700 | 1 | |a Cappelli, Gianni |e investigator |4 oth | |
| 700 | 1 | |a Magistroni, Riccardo |e investigator |4 oth | |
| 700 | 1 | |a Alfano, Gaetano |e investigator |4 oth | |
| 700 | 1 | |a Fontana, Francesco |e investigator |4 oth | |
| 700 | 1 | |a Marco, Ballestri |e investigator |4 oth | |
| 700 | 1 | |a Mori, Giacomo |e investigator |4 oth | |
| 700 | 1 | |a Pulizzi, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Ascione, Elisabetta |e investigator |4 oth | |
| 700 | 1 | |a Leonelli, Marco |e investigator |4 oth | |
| 700 | 1 | |a Facchini, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Damiano, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Girardis, Massimo |e investigator |4 oth | |
| 700 | 1 | |a Andreotti, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Biagioni, Emanuela |e investigator |4 oth | |
| 700 | 1 | |a Bondi, Filippo |e investigator |4 oth | |
| 700 | 1 | |a Busani, Stefano |e investigator |4 oth | |
| 700 | 1 | |a Chierego, Giovanni |e investigator |4 oth | |
| 700 | 1 | |a Scotti, Marzia |e investigator |4 oth | |
| 700 | 1 | |a Cossarizza, Lucia Serio Andrea |e investigator |4 oth | |
| 700 | 1 | |a Bellinazzi, Caterina |e investigator |4 oth | |
| 700 | 1 | |a Borella, Rebecca |e investigator |4 oth | |
| 700 | 1 | |a De Biasi, Sara |e investigator |4 oth | |
| 700 | 1 | |a De Gaetano, Anna |e investigator |4 oth | |
| 700 | 1 | |a Fidanza, Lucia |e investigator |4 oth | |
| 700 | 1 | |a Gibellini, Lara |e investigator |4 oth | |
| 700 | 1 | |a Iannone, Anna |e investigator |4 oth | |
| 700 | 1 | |a Tartaro, Domenico Lo |e investigator |4 oth | |
| 700 | 1 | |a Mattioli, Marco |e investigator |4 oth | |
| 700 | 1 | |a Nasi, Milena |e investigator |4 oth | |
| 700 | 1 | |a Paolini, Annamaria |e investigator |4 oth | |
| 700 | 1 | |a Pinti, Marcello |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical and experimental nephrology |d 1998 |g 25(2021), 4 vom: 04. Apr., Seite 401-409 |w (DE-627)NLM096492473 |x 1437-7799 |7 nnns |
| 773 | 1 | 8 | |g volume:25 |g year:2021 |g number:4 |g day:04 |g month:04 |g pages:401-409 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10157-020-01996-4 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 25 |j 2021 |e 4 |b 04 |c 04 |h 401-409 | ||