Quantitative OCT angiography of the retinal microvasculature and choriocapillaris in highly myopic eyes with myopic macular degeneration
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ..
PURPOSE: To quantify retinal and choriocapillaris (CC) microvasculature in highly myopic (HM) eyes with myopic macular degeneration (MMD) using swept-source optical coherence tomography angiography (SS-OCTA).
METHODS: 162 HM eyes (spherical equivalent ≤ -6.0 dioptres or axial length (AL) ≥26.5 mm) from 98 participants were enrolled, including 60 eyes (37.0%) with tessellated fundus, 54 eyes (33.3%) with peripapillary diffuse chorioretinal atrophy (PDCA), 27 eyes (16.7%) with macular diffuse chorioretinal atrophy (MDCA) and 21 eyes (13.0%) with patchy or macular atrophy. PLEX Elite 9000 SS-OCTA was performed to obtain perfusion densities (PD) of the superficial and deep retinal capillary plexus, and CC signal voids (number, area and density).
RESULTS: Retinal PD decreased with increasing severity of MMD. Multivariable analysis showed that after adjustment of age and other factors, retinal PD decreased significantly in eyes with longer AL (β≤-0.51, p<0.001) and with an MMD severity of MDCA or worse (β≤-1.63, p<0.001). Reduced retinal PD were significantly associated with worse vision (β≤-0.01, p≤0.04). In terms of CC signal voids, multivariable analysis showed that longer AL (p<0.001), but not MMD severity (p≥0.12) was significantly associated with CC signal void changes in the earliest stage of MMD.
CONCLUSION: We demonstrate significant OCTA alterations in the retina and CC in HM eyes with varying severities of MMD. In eyes with early-stage PDCA, lower retinal PD and more extensive CC signal voids are predominantly associated with increasing AL. In contrast, in eyes with MDCA or worse, MMD itself was associated with sparser retinal and CC circulation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:106 |
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| Enthalten in: |
The British journal of ophthalmology - 106(2022), 5 vom: 04. Mai, Seite 681-688 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zheng, Feihui [VerfasserIn] |
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| Links: |
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| Themen: |
Choroid |
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| Anmerkungen: |
Date Completed 25.04.2022 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bjophthalmol-2020-317632 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31961591X |
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| 041 | |a eng | ||
| 100 | 1 | |a Zheng, Feihui |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Quantitative OCT angiography of the retinal microvasculature and choriocapillaris in highly myopic eyes with myopic macular degeneration |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 25.04.2022 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a PURPOSE: To quantify retinal and choriocapillaris (CC) microvasculature in highly myopic (HM) eyes with myopic macular degeneration (MMD) using swept-source optical coherence tomography angiography (SS-OCTA) | ||
| 520 | |a METHODS: 162 HM eyes (spherical equivalent ≤ -6.0 dioptres or axial length (AL) ≥26.5 mm) from 98 participants were enrolled, including 60 eyes (37.0%) with tessellated fundus, 54 eyes (33.3%) with peripapillary diffuse chorioretinal atrophy (PDCA), 27 eyes (16.7%) with macular diffuse chorioretinal atrophy (MDCA) and 21 eyes (13.0%) with patchy or macular atrophy. PLEX Elite 9000 SS-OCTA was performed to obtain perfusion densities (PD) of the superficial and deep retinal capillary plexus, and CC signal voids (number, area and density) | ||
| 520 | |a RESULTS: Retinal PD decreased with increasing severity of MMD. Multivariable analysis showed that after adjustment of age and other factors, retinal PD decreased significantly in eyes with longer AL (β≤-0.51, p<0.001) and with an MMD severity of MDCA or worse (β≤-1.63, p<0.001). Reduced retinal PD were significantly associated with worse vision (β≤-0.01, p≤0.04). In terms of CC signal voids, multivariable analysis showed that longer AL (p<0.001), but not MMD severity (p≥0.12) was significantly associated with CC signal void changes in the earliest stage of MMD | ||
| 520 | |a CONCLUSION: We demonstrate significant OCTA alterations in the retina and CC in HM eyes with varying severities of MMD. In eyes with early-stage PDCA, lower retinal PD and more extensive CC signal voids are predominantly associated with increasing AL. In contrast, in eyes with MDCA or worse, MMD itself was associated with sparser retinal and CC circulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a choroid | |
| 650 | 4 | |a degeneration | |
| 650 | 4 | |a imaging | |
| 650 | 4 | |a macula | |
| 650 | 4 | |a retina | |
| 700 | 1 | |a Chua, Jacqueline |e verfasserin |4 aut | |
| 700 | 1 | |a Ke, Mengyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Bingyao |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Qinglan |e verfasserin |4 aut | |
| 700 | 1 | |a Cheung, Chui Ming Gemmy |e verfasserin |4 aut | |
| 700 | 1 | |a Ang, Marcus |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Shu Yen |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Tien Yin |e verfasserin |4 aut | |
| 700 | 0 | |a SNEC Retina Group |e verfasserin |4 aut | |
| 700 | 1 | |a Schmetterer, Leopold |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Chee Wai |e verfasserin |4 aut | |
| 700 | 1 | |a Hoang, Quan V |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Edmund Yick Mun |e investigator |4 oth | |
| 700 | 1 | |a Wong, Doric Wen Kuan |e investigator |4 oth | |
| 700 | 1 | |a Ang, Chong Lye |e investigator |4 oth | |
| 700 | 1 | |a Yeo, Ian Yew San |e investigator |4 oth | |
| 700 | 1 | |a Tan, Gavin Siew Wei |e investigator |4 oth | |
| 700 | 1 | |a Lim, Laurence Shen |e investigator |4 oth | |
| 700 | 1 | |a Cheung, Ning |e investigator |4 oth | |
| 700 | 1 | |a Ting, Daniel Shu Wei |e investigator |4 oth | |
| 700 | 1 | |a Tsai, Andrew Shih Hsiang |e investigator |4 oth | |
| 700 | 1 | |a Mathur, Ranjana |e investigator |4 oth | |
| 700 | 1 | |a Chan, Choi Mun |e investigator |4 oth | |
| 700 | 1 | |a Tan, Anna Cheng Sim |e investigator |4 oth | |
| 700 | 1 | |a Teo, Kelvin Yi Chong |e investigator |4 oth | |
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