Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19 : a quantitative correlation study with histopathological findings
PURPOSE: This study was designed to evaluate the usefulness of lung ultrasound (LUS) imaging to characterize the progression and severity of lung damage in cases of COVID-19.
METHODS: We employed a set of combined ultrasound parameters and histopathological images obtained simultaneously in 28 patients (15 women, 0.6-83 years) with fatal COVID-19 submitted to minimally invasive autopsies, with different times of disease evolution from initial symptoms to death (3-37 days, median 18 days). For each patient, we analysed eight post-mortem LUS parameters and the proportion of three histological patterns (normal lung, exudative diffuse alveolar damage [DAD] and fibroproliferative DAD) in eight different lung regions. The relationship between histopathological and post-mortem ultrasonographic findings was assessed using various statistical approaches.
RESULTS: Statistically significant positive correlations were observed between fibroproliferative DAD and peripheral consolidation (coefficient 0.43, p = 0.02) and pulmonary consolidation (coefficient 0.51, p = 0.005). A model combining age, time of evolution, sex and ultrasound score predicted reasonably well (r = 0.66) the proportion of pulmonary parenchyma with fibroproliferative DAD.
CONCLUSION: The present study adds information to previous studies related to the use of LUS as a tool to assess the severity of acute pulmonary damage. We provide a histological background that supports the concept that LUS can be used to characterize the progression and severity of lung damage in severe COVID-19.
| Errataetall: |
CommentIn: Intensive Care Med. 2021 May;47(5):629-630. - PMID 33630096 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
|---|---|
| Enthalten in: |
Intensive care medicine - 47(2021), 2 vom: 29. Feb., Seite 199-207 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Almeida Monteiro, Renata Aparecida [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acute lung injury |
|---|
| Anmerkungen: |
Date Completed 25.02.2021 Date Revised 17.09.2023 published: Print-Electronic CommentIn: Intensive Care Med. 2021 May;47(5):629-630. - PMID 33630096 Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00134-020-06328-4 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM319566390 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM319566390 | ||
| 003 | DE-627 | ||
| 005 | 20231225171725.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00134-020-06328-4 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1065.xml |
| 035 | |a (DE-627)NLM319566390 | ||
| 035 | |a (NLM)33392642 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Almeida Monteiro, Renata Aparecida |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19 |b a quantitative correlation study with histopathological findings |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.02.2021 | ||
| 500 | |a Date Revised 17.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Intensive Care Med. 2021 May;47(5):629-630. - PMID 33630096 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: This study was designed to evaluate the usefulness of lung ultrasound (LUS) imaging to characterize the progression and severity of lung damage in cases of COVID-19 | ||
| 520 | |a METHODS: We employed a set of combined ultrasound parameters and histopathological images obtained simultaneously in 28 patients (15 women, 0.6-83 years) with fatal COVID-19 submitted to minimally invasive autopsies, with different times of disease evolution from initial symptoms to death (3-37 days, median 18 days). For each patient, we analysed eight post-mortem LUS parameters and the proportion of three histological patterns (normal lung, exudative diffuse alveolar damage [DAD] and fibroproliferative DAD) in eight different lung regions. The relationship between histopathological and post-mortem ultrasonographic findings was assessed using various statistical approaches | ||
| 520 | |a RESULTS: Statistically significant positive correlations were observed between fibroproliferative DAD and peripheral consolidation (coefficient 0.43, p = 0.02) and pulmonary consolidation (coefficient 0.51, p = 0.005). A model combining age, time of evolution, sex and ultrasound score predicted reasonably well (r = 0.66) the proportion of pulmonary parenchyma with fibroproliferative DAD | ||
| 520 | |a CONCLUSION: The present study adds information to previous studies related to the use of LUS as a tool to assess the severity of acute pulmonary damage. We provide a histological background that supports the concept that LUS can be used to characterize the progression and severity of lung damage in severe COVID-19 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Acute lung injury | |
| 650 | 4 | |a Autopsy | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Diffuse alveolar damage | |
| 650 | 4 | |a Lung ultrasound | |
| 650 | 4 | |a Minimally invasive autopsy | |
| 650 | 4 | |a Pathology | |
| 700 | 1 | |a Duarte-Neto, Amaro Nunes |e verfasserin |4 aut | |
| 700 | 1 | |a Ferraz da Silva, Luiz Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira, Ellen Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a do Nascimento, Ellen Caroline Toledo |e verfasserin |4 aut | |
| 700 | 1 | |a Mauad, Thais |e verfasserin |4 aut | |
| 700 | 1 | |a Saldiva, Paulo Hilário do Nascimento |e verfasserin |4 aut | |
| 700 | 1 | |a Dolhnikoff, Marisa |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Intensive care medicine |d 1993 |g 47(2021), 2 vom: 29. Feb., Seite 199-207 |w (DE-627)NLM000234818 |x 1432-1238 |7 nnns |
| 773 | 1 | 8 | |g volume:47 |g year:2021 |g number:2 |g day:29 |g month:02 |g pages:199-207 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00134-020-06328-4 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 47 |j 2021 |e 2 |b 29 |c 02 |h 199-207 | ||