Effect of Endovascular Treatment on Systemic Vascular Resistance in Patients with Lower-Limb Peripheral Artery Disease
© 2020 The Editorial Committee of Annals of Vascular Diseases..
Objective: Endovascular treatment (EVT) for lower-limb peripheral artery disease patients reduces blood pressure (BP) and improves prognosis. This study retrospectively examined hemodynamics during EVT to clarify the mechanism. Materials and Methods: Systemic vascular resistance (SVR) was measured using a noninvasive continuous cardiac output monitoring system during EVT. Furthermore, ankle brachial index was measured before and after EVT. Results: The study included 88 lesions of 56 patients (hypertension in 98%). SVR significantly decreased from 2409.1±746.8 dynes·s·cm-5 to 2033.7±635.0 dynes·s·cm-5 (p<0.0001). The difference in SVR before and after EVT was significantly greater in the Fontaine IV group than in the Fontaine IIa group (554.7±406.6 dynes·s·cm-5 vs. 312.9±245.7 dynes·s·cm-5, p=0.0151). The change in SVR was correlated with a change in mean BP in the upper limb (p=0.0026). When the change in pressure gradient between the upper limb and the diseased lower limb was large, mean BP of the upper limb significantly decreased (p=0.0022). Conclusion: EVT can reduce SVR and BP by canceling the pressure gradient between central BP and diseased lower-limb BP.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Annals of vascular diseases - 13(2020), 4 vom: 25. Dez., Seite 377-383 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nomoto, Hidetsugu [VerfasserIn] |
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| Links: |
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| Themen: |
Antihypertensive |
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| Anmerkungen: |
Date Revised 05.01.2021 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3400/avd.oa.20-00086 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319555526 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2020 The Editorial Committee of Annals of Vascular Diseases. | ||
| 520 | |a Objective: Endovascular treatment (EVT) for lower-limb peripheral artery disease patients reduces blood pressure (BP) and improves prognosis. This study retrospectively examined hemodynamics during EVT to clarify the mechanism. Materials and Methods: Systemic vascular resistance (SVR) was measured using a noninvasive continuous cardiac output monitoring system during EVT. Furthermore, ankle brachial index was measured before and after EVT. Results: The study included 88 lesions of 56 patients (hypertension in 98%). SVR significantly decreased from 2409.1±746.8 dynes·s·cm-5 to 2033.7±635.0 dynes·s·cm-5 (p<0.0001). The difference in SVR before and after EVT was significantly greater in the Fontaine IV group than in the Fontaine IIa group (554.7±406.6 dynes·s·cm-5 vs. 312.9±245.7 dynes·s·cm-5, p=0.0151). The change in SVR was correlated with a change in mean BP in the upper limb (p=0.0026). When the change in pressure gradient between the upper limb and the diseased lower limb was large, mean BP of the upper limb significantly decreased (p=0.0022). Conclusion: EVT can reduce SVR and BP by canceling the pressure gradient between central BP and diseased lower-limb BP | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a endovascular treatment | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a noninvasive continuous cardiac output monitoring | |
| 650 | 4 | |a peripheral artery disease | |
| 700 | 1 | |a Nozato, Toshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yamashita, Shu |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Masahito |e verfasserin |4 aut | |
| 700 | 1 | |a Sugiyama, Tomoyo |e verfasserin |4 aut | |
| 700 | 1 | |a Oumi, Tetsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Ohno, Masakazu |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Shigeo |e verfasserin |4 aut | |
| 700 | 1 | |a Ashikaga, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Satoh, Yasuhiro |e verfasserin |4 aut | |
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