Cancer or vitamin B12 deficiency? Difficult differential diagnosis in elderly
© 2020 MEDPRESS..
Vitamin B12 deficiency anaemia in adults is usually caused by Addison- Biermer's disease. The presence of antibodies against gastric parietal cells and intrinsic factor (IF) in blood is typical for the disease. The gastrointestinal malabsorption or a diet poor in vitamin B12 are rarer causes. The disease manifests in hematological, neurological, psychiatric disorders and trophic changes of the tongue and oral mucosa, which leads to weight loss.
A CASE REPORT: The authors describe a case of a 70-year-old woman with severe vitamin B12 deficiency based on chronic inflammatory lesions of the gastric mucosa caused by Helicobacter pylori infection. The patient had haematological (pancytopenia), neurological (problems with memory, concentration, numbness of the limbs, gait instability) and gastrological disorders (loss of appetite, weight loss). The laboratory and imaging diagnostics were performed. The neoplasmatic background was abandoned and pure vitamin B12 deficiency was diagnosed. All symptoms resolved completely after the supplementation and eradication of Helicobacter pylori.
CONCLUSIONS: The article demonstrates the problem of many severe, non- specific complications of vitamin B12 deficiency which requires extensive diagnostics and treatment. The similarity of symptoms may suggest a malignant disease especially in elderly patients.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego - 48(2020), 288 vom: 22. Dez., Seite 446-448 |
| Sprache: |
Polnisch |
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| Weiterer Titel: |
Nowotwór czy niedobór witaminy B12? Trudna diagnostyka różnicowa u osób starszych |
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| Beteiligte Personen: |
Simankowicz, Paulina [VerfasserIn] |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 05.01.2021 Date Revised 19.04.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319514552 |
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| 245 | 1 | 0 | |a Cancer or vitamin B12 deficiency? Difficult differential diagnosis in elderly |
| 246 | 3 | 3 | |a Nowotwór czy niedobór witaminy B12? Trudna diagnostyka różnicowa u osób starszych |
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| 500 | |a Date Completed 05.01.2021 | ||
| 500 | |a Date Revised 19.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 MEDPRESS. | ||
| 520 | |a Vitamin B12 deficiency anaemia in adults is usually caused by Addison- Biermer's disease. The presence of antibodies against gastric parietal cells and intrinsic factor (IF) in blood is typical for the disease. The gastrointestinal malabsorption or a diet poor in vitamin B12 are rarer causes. The disease manifests in hematological, neurological, psychiatric disorders and trophic changes of the tongue and oral mucosa, which leads to weight loss | ||
| 520 | |a A CASE REPORT: The authors describe a case of a 70-year-old woman with severe vitamin B12 deficiency based on chronic inflammatory lesions of the gastric mucosa caused by Helicobacter pylori infection. The patient had haematological (pancytopenia), neurological (problems with memory, concentration, numbness of the limbs, gait instability) and gastrological disorders (loss of appetite, weight loss). The laboratory and imaging diagnostics were performed. The neoplasmatic background was abandoned and pure vitamin B12 deficiency was diagnosed. All symptoms resolved completely after the supplementation and eradication of Helicobacter pylori | ||
| 520 | |a CONCLUSIONS: The article demonstrates the problem of many severe, non- specific complications of vitamin B12 deficiency which requires extensive diagnostics and treatment. The similarity of symptoms may suggest a malignant disease especially in elderly patients | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Helicobacter pylori | |
| 650 | 4 | |a Intrinsic Factor | |
| 650 | 4 | |a megaloblastic anemia | |
| 650 | 4 | |a pernicious anemia | |
| 650 | 4 | |a vitamin B12 deficiency | |
| 700 | 1 | |a Stępniewska, Joanna |e verfasserin |4 aut | |
| 700 | 1 | |a Różański, Jacek |e verfasserin |4 aut | |
| 700 | 1 | |a Ciechanowski, Kazimierz |e verfasserin |4 aut | |
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