Clinical Value of CT for Differentiation between Ascites and Hemorrhage : An Experimental In-Vitro Study
BACKGROUND: Abdominal trauma, leading to intra-abdominal bleeding, is a life-threatening condition that might need emergency surgical intervention. Sonography and Computed Tomography (CT) are most commonly used to detect free intra-abdominal fluid. This study investigates the accuracy of CT to distinguish between ascites and intra-abdominal hemorrhage.
METHODS: Ascites were collected during a clinical routine. Three serial dilutions, mixing ascites with whole blood samples of the patient and with two blood group identical donors, were prepared. Laboratory-chemical analysis and radiological evaluation using CT with measurement of average Hounsfield Units (HU) were performed.
RESULTS: Between ascites and whole blood as well as between ascites and the 1:1-ratio-samples, HU values differed significantly (p < 0.001). All further dilutions showed HU values with no significant difference compared to ascites (p ≥ 0.42). Whole blood showed significantly higher HU values than ascites and every step of the serial dilutions (p < 0.001). Measured HU values were also dependent on time and the exact point of measurement in the micro reaction vessels.
CONCLUSIONS: In patients suffering from blunt abdominal trauma with preexisting ascites, HU values in CT imaging are not valid enough to exclude an acute hemorrhage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Journal of clinical medicine - 10(2020), 1 vom: 28. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kerschbaum, Maximilian [VerfasserIn] |
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| Links: |
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| Themen: |
Abdominal injuries |
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| Anmerkungen: |
Date Revised 11.01.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jcm10010076 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319433234 |
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| 100 | 1 | |a Kerschbaum, Maximilian |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical Value of CT for Differentiation between Ascites and Hemorrhage |b An Experimental In-Vitro Study |
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| 500 | |a Date Revised 11.01.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Abdominal trauma, leading to intra-abdominal bleeding, is a life-threatening condition that might need emergency surgical intervention. Sonography and Computed Tomography (CT) are most commonly used to detect free intra-abdominal fluid. This study investigates the accuracy of CT to distinguish between ascites and intra-abdominal hemorrhage | ||
| 520 | |a METHODS: Ascites were collected during a clinical routine. Three serial dilutions, mixing ascites with whole blood samples of the patient and with two blood group identical donors, were prepared. Laboratory-chemical analysis and radiological evaluation using CT with measurement of average Hounsfield Units (HU) were performed | ||
| 520 | |a RESULTS: Between ascites and whole blood as well as between ascites and the 1:1-ratio-samples, HU values differed significantly (p < 0.001). All further dilutions showed HU values with no significant difference compared to ascites (p ≥ 0.42). Whole blood showed significantly higher HU values than ascites and every step of the serial dilutions (p < 0.001). Measured HU values were also dependent on time and the exact point of measurement in the micro reaction vessels | ||
| 520 | |a CONCLUSIONS: In patients suffering from blunt abdominal trauma with preexisting ascites, HU values in CT imaging are not valid enough to exclude an acute hemorrhage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a abdominal injuries | |
| 650 | 4 | |a ascites | |
| 650 | 4 | |a computed tomography | |
| 650 | 4 | |a hemorrhage | |
| 650 | 4 | |a trauma | |
| 700 | 1 | |a Schurr, Leonhard Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Riedl, Moritz |e verfasserin |4 aut | |
| 700 | 1 | |a Mayr, Agnes |e verfasserin |4 aut | |
| 700 | 1 | |a Weiß, Isabella |e verfasserin |4 aut | |
| 700 | 1 | |a Klute, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Popp, Daniel |e verfasserin |4 aut | |
| 700 | 1 | |a Pfeifer, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Ernstberger, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Alt, Volker |e verfasserin |4 aut | |
| 700 | 1 | |a Dendl, Lena Marie |e verfasserin |4 aut | |
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