Effects of topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity in ophthalmologically normal cats
OBJECTIVE: To investigate the effects of short-term and prolonged topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity (CS) in ophthalmologically normal cats.
ANIMALS: 12 healthy adult domestic shorthair cats.
PROCEDURES: In the first of 2 study phases, each cat received 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, 0.03% flurbiprofen sodium, and saline (0.9% NaCl; control) solutions (1 drop [0.05 mL]/eye, q 5 min for 5 treatments) in a randomized order with a 2-day washout period between treatments. For each cat, an esthesiometer was used to measure CS before treatment initiation (baseline) and at 15, 30, 45, and 60 minutes after the last dose. There was a 2-day washout period between phases. The second phase was similar to the first, except each treatment was administered at a dosage of 1 drop/eye, twice daily for 5 days and CS was measured before treatment initiation and at 15 minutes and 24 and 48 hours after the last dose. The Friedman test was used to evaluate change in CS over time.
RESULTS: None of the 4 treatments had a significant effect on CS over time in either study phase.
CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that neither short-term nor prolonged topical instillation of 3 NSAID ophthalmic solutions had any effect on the CS of healthy cats. Given potential differences in cyclooxygenase expression between healthy and diseased eyes, further investigation of the effects of topical NSAID instillation in the eyes of cats with ocular surface inflammation is warranted.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
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| Enthalten in: |
American journal of veterinary research - 82(2021), 1 vom: 28. Jan., Seite 81-87 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Roberts, Jordan K [VerfasserIn] |
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| Links: |
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| Themen: |
144O8QL0L1 |
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| Anmerkungen: |
Date Completed 30.12.2020 Date Revised 31.05.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.2460/ajvr.82.1.81 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319337456 |
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| 100 | 1 | |a Roberts, Jordan K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity in ophthalmologically normal cats |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 30.12.2020 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To investigate the effects of short-term and prolonged topical instillation of 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, and 0.03% flurbiprofen sodium on corneal sensitivity (CS) in ophthalmologically normal cats | ||
| 520 | |a ANIMALS: 12 healthy adult domestic shorthair cats | ||
| 520 | |a PROCEDURES: In the first of 2 study phases, each cat received 0.1% diclofenac sodium, 0.5% ketorolac tromethamine, 0.03% flurbiprofen sodium, and saline (0.9% NaCl; control) solutions (1 drop [0.05 mL]/eye, q 5 min for 5 treatments) in a randomized order with a 2-day washout period between treatments. For each cat, an esthesiometer was used to measure CS before treatment initiation (baseline) and at 15, 30, 45, and 60 minutes after the last dose. There was a 2-day washout period between phases. The second phase was similar to the first, except each treatment was administered at a dosage of 1 drop/eye, twice daily for 5 days and CS was measured before treatment initiation and at 15 minutes and 24 and 48 hours after the last dose. The Friedman test was used to evaluate change in CS over time | ||
| 520 | |a RESULTS: None of the 4 treatments had a significant effect on CS over time in either study phase | ||
| 520 | |a CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that neither short-term nor prolonged topical instillation of 3 NSAID ophthalmic solutions had any effect on the CS of healthy cats. Given potential differences in cyclooxygenase expression between healthy and diseased eyes, further investigation of the effects of topical NSAID instillation in the eyes of cats with ocular surface inflammation is warranted | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial, Veterinary | |
| 650 | 7 | |a Anti-Inflammatory Agents, Non-Steroidal |2 NLM | |
| 650 | 7 | |a Ophthalmic Solutions |2 NLM | |
| 650 | 7 | |a Diclofenac |2 NLM | |
| 650 | 7 | |a 144O8QL0L1 |2 NLM | |
| 650 | 7 | |a Ketorolac Tromethamine |2 NLM | |
| 650 | 7 | |a 4EVE5946BQ |2 NLM | |
| 650 | 7 | |a Flurbiprofen |2 NLM | |
| 650 | 7 | |a 5GRO578KLP |2 NLM | |
| 700 | 1 | |a Meekins, Jessica M |e verfasserin |4 aut | |
| 700 | 1 | |a Roush, James K |e verfasserin |4 aut | |
| 700 | 1 | |a Rankin, Amy J |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:82 |g year:2021 |g number:1 |g day:28 |g month:01 |g pages:81-87 |
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