Primary sclerosing cholangitis as an independent risk factor for cytomegalovirus infection after liver transplant
© 2020 The Authors. Transplant Infectious Disease published by Wiley Periodicals LLC..
BACKGROUND: Cytomegalovirus (CMV) infection is one of the most common infectious complications after solid organ transplant; it is associated with morbidity and mortality and with many direct and indirect effects. However, monitoring and therapeutic procedures are very heterogeneous across treatment centers. Additionally, factors that place patients at risk of CMV infection are poorly defined.
METHODS: Clinical and demographic data from 833 LT recipients and their donors were retrospectively analyzed. Univariate and multivariate analysis were applied. CMV infection was detected by quantitative nucleic acid testing with a lower limit of detection of 40 IU/mL.
RESULTS: In total, 192 of 833 patients (23%) experienced at least one episode of CMV infection after LT; CMV infection occurred to a large extent during the first year after transplant (70%). Multivariate analysis demonstrated that CMV donor-recipient risk constellation (OR 2.05, 95% CI) and primary sclerosing cholangitis (PSC) before LT (OR 3.76, 95% CI) are independent risk factors for CMV infection after LT.
CONCLUSION: Patients with high-risk serostatus, PSC, or both should be monitored more thoroughly and should receive prolonged prophylaxis against CMV infection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Transplant infectious disease : an official journal of the Transplantation Society - 23(2021), 3 vom: 16. Juni, Seite e13553 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rashidi-Alavijeh, Jassin [VerfasserIn] |
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| Links: |
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| Themen: |
Antiviral Agents |
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| Anmerkungen: |
Date Completed 02.08.2021 Date Revised 02.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/tid.13553 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319332446 |
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| 245 | 1 | 0 | |a Primary sclerosing cholangitis as an independent risk factor for cytomegalovirus infection after liver transplant |
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| 500 | |a Date Completed 02.08.2021 | ||
| 500 | |a Date Revised 02.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. Transplant Infectious Disease published by Wiley Periodicals LLC. | ||
| 520 | |a BACKGROUND: Cytomegalovirus (CMV) infection is one of the most common infectious complications after solid organ transplant; it is associated with morbidity and mortality and with many direct and indirect effects. However, monitoring and therapeutic procedures are very heterogeneous across treatment centers. Additionally, factors that place patients at risk of CMV infection are poorly defined | ||
| 520 | |a METHODS: Clinical and demographic data from 833 LT recipients and their donors were retrospectively analyzed. Univariate and multivariate analysis were applied. CMV infection was detected by quantitative nucleic acid testing with a lower limit of detection of 40 IU/mL | ||
| 520 | |a RESULTS: In total, 192 of 833 patients (23%) experienced at least one episode of CMV infection after LT; CMV infection occurred to a large extent during the first year after transplant (70%). Multivariate analysis demonstrated that CMV donor-recipient risk constellation (OR 2.05, 95% CI) and primary sclerosing cholangitis (PSC) before LT (OR 3.76, 95% CI) are independent risk factors for CMV infection after LT | ||
| 520 | |a CONCLUSION: Patients with high-risk serostatus, PSC, or both should be monitored more thoroughly and should receive prolonged prophylaxis against CMV infection | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a liver transplant | |
| 650 | 4 | |a primary sclerosing cholangitis | |
| 650 | 4 | |a risk factors | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 700 | 1 | |a Crämer, Jens Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Sauter, Helena Louisa |e verfasserin |4 aut | |
| 700 | 1 | |a Willuweit, Katharina |e verfasserin |4 aut | |
| 700 | 1 | |a Straub, Katja |e verfasserin |4 aut | |
| 700 | 1 | |a Wedemeyer, Heiner |e verfasserin |4 aut | |
| 700 | 1 | |a Herzer, Kerstin |e verfasserin |4 aut | |
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