Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19-; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: -82.5 ± 27.2 points; C19-: -59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0-10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable.
Errataetall: | |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
---|---|
Enthalten in: |
Chemical senses - 46(2021) vom: 01. Jan. |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Gerkin, Richard C [VerfasserIn] |
---|
Links: |
---|
Themen: |
Anosmia |
---|
Anmerkungen: |
Date Completed 09.03.2021 Date Revised 14.02.2024 published: Print UpdateOf: medRxiv. 2020 Jul 28;:. - PMID 32743605 Citation Status MEDLINE |
---|
doi: |
10.1093/chemse/bjaa081 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM319317730 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM319317730 | ||
003 | DE-627 | ||
005 | 20240214232252.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1093/chemse/bjaa081 |2 doi | |
028 | 5 | 2 | |a pubmed24n1292.xml |
035 | |a (DE-627)NLM319317730 | ||
035 | |a (NLM)33367502 | ||
035 | |a (PII)bjaa081 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Gerkin, Richard C |e verfasserin |4 aut | |
245 | 1 | 0 | |a Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 09.03.2021 | ||
500 | |a Date Revised 14.02.2024 | ||
500 | |a published: Print | ||
500 | |a UpdateOf: medRxiv. 2020 Jul 28;:. - PMID 32743605 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
520 | |a In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19-; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: -82.5 ± 27.2 points; C19-: -59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0-10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a anosmia | |
650 | 4 | |a chemosensory | |
650 | 4 | |a coronavirus | |
650 | 4 | |a hyposmia | |
650 | 4 | |a olfactory | |
650 | 4 | |a prediction | |
700 | 1 | |a Ohla, Kathrin |e verfasserin |4 aut | |
700 | 1 | |a Veldhuizen, Maria G |e verfasserin |4 aut | |
700 | 1 | |a Joseph, Paule V |e verfasserin |4 aut | |
700 | 1 | |a Kelly, Christine E |e verfasserin |4 aut | |
700 | 1 | |a Bakke, Alyssa J |e verfasserin |4 aut | |
700 | 1 | |a Steele, Kimberley E |e verfasserin |4 aut | |
700 | 1 | |a Farruggia, Michael C |e verfasserin |4 aut | |
700 | 1 | |a Pellegrino, Robert |e verfasserin |4 aut | |
700 | 1 | |a Pepino, Marta Y |e verfasserin |4 aut | |
700 | 1 | |a Bouysset, Cédric |e verfasserin |4 aut | |
700 | 1 | |a Soler, Graciela M |e verfasserin |4 aut | |
700 | 1 | |a Pereda-Loth, Veronica |e verfasserin |4 aut | |
700 | 1 | |a Dibattista, Michele |e verfasserin |4 aut | |
700 | 1 | |a Cooper, Keiland W |e verfasserin |4 aut | |
700 | 1 | |a Croijmans, Ilja |e verfasserin |4 aut | |
700 | 1 | |a Di Pizio, Antonella |e verfasserin |4 aut | |
700 | 1 | |a Ozdener, Mehmet Hakan |e verfasserin |4 aut | |
700 | 1 | |a Fjaeldstad, Alexander W |e verfasserin |4 aut | |
700 | 1 | |a Lin, Cailu |e verfasserin |4 aut | |
700 | 1 | |a Sandell, Mari A |e verfasserin |4 aut | |
700 | 1 | |a Singh, Preet B |e verfasserin |4 aut | |
700 | 1 | |a Brindha, V Evelyn |e verfasserin |4 aut | |
700 | 1 | |a Olsson, Shannon B |e verfasserin |4 aut | |
700 | 1 | |a Saraiva, Luis R |e verfasserin |4 aut | |
700 | 1 | |a Ahuja, Gaurav |e verfasserin |4 aut | |
700 | 1 | |a Alwashahi, Mohammed K |e verfasserin |4 aut | |
700 | 1 | |a Bhutani, Surabhi |e verfasserin |4 aut | |
700 | 1 | |a D'Errico, Anna |e verfasserin |4 aut | |
700 | 1 | |a Fornazieri, Marco A |e verfasserin |4 aut | |
700 | 1 | |a Golebiowski, Jérôme |e verfasserin |4 aut | |
700 | 1 | |a Dar Hwang, Liang |e verfasserin |4 aut | |
700 | 1 | |a Öztürk, Lina |e verfasserin |4 aut | |
700 | 1 | |a Roura, Eugeni |e verfasserin |4 aut | |
700 | 1 | |a Spinelli, Sara |e verfasserin |4 aut | |
700 | 1 | |a Whitcroft, Katherine L |e verfasserin |4 aut | |
700 | 1 | |a Faraji, Farhoud |e verfasserin |4 aut | |
700 | 1 | |a Fischmeister, Florian Ph S |e verfasserin |4 aut | |
700 | 1 | |a Heinbockel, Thomas |e verfasserin |4 aut | |
700 | 1 | |a Hsieh, Julien W |e verfasserin |4 aut | |
700 | 1 | |a Huart, Caroline |e verfasserin |4 aut | |
700 | 1 | |a Konstantinidis, Iordanis |e verfasserin |4 aut | |
700 | 1 | |a Menini, Anna |e verfasserin |4 aut | |
700 | 1 | |a Morini, Gabriella |e verfasserin |4 aut | |
700 | 1 | |a Olofsson, Jonas K |e verfasserin |4 aut | |
700 | 1 | |a Philpott, Carl M |e verfasserin |4 aut | |
700 | 1 | |a Pierron, Denis |e verfasserin |4 aut | |
700 | 1 | |a Shields, Vonnie D C |e verfasserin |4 aut | |
700 | 1 | |a Voznessenskaya, Vera V |e verfasserin |4 aut | |
700 | 1 | |a Albayay, Javier |e verfasserin |4 aut | |
700 | 1 | |a Altundag, Aytug |e verfasserin |4 aut | |
700 | 1 | |a Bensafi, Moustafa |e verfasserin |4 aut | |
700 | 1 | |a Bock, María Adelaida |e verfasserin |4 aut | |
700 | 1 | |a Calcinoni, Orietta |e verfasserin |4 aut | |
700 | 1 | |a Fredborg, William |e verfasserin |4 aut | |
700 | 1 | |a Laudamiel, Christophe |e verfasserin |4 aut | |
700 | 1 | |a Lim, Juyun |e verfasserin |4 aut | |
700 | 1 | |a Lundström, Johan N |e verfasserin |4 aut | |
700 | 1 | |a Macchi, Alberto |e verfasserin |4 aut | |
700 | 1 | |a Meyer, Pablo |e verfasserin |4 aut | |
700 | 1 | |a Moein, Shima T |e verfasserin |4 aut | |
700 | 1 | |a Santamaría, Enrique |e verfasserin |4 aut | |
700 | 1 | |a Sengupta, Debarka |e verfasserin |4 aut | |
700 | 1 | |a Rohlfs Dominguez, Paloma |e verfasserin |4 aut | |
700 | 1 | |a Yanik, Hüseyin |e verfasserin |4 aut | |
700 | 1 | |a Hummel, Thomas |e verfasserin |4 aut | |
700 | 1 | |a Hayes, John E |e verfasserin |4 aut | |
700 | 1 | |a Reed, Danielle R |e verfasserin |4 aut | |
700 | 1 | |a Niv, Masha Y |e verfasserin |4 aut | |
700 | 1 | |a Munger, Steven D |e verfasserin |4 aut | |
700 | 1 | |a Parma, Valentina |e verfasserin |4 aut | |
700 | 0 | |a GCCR Group Author |e verfasserin |4 aut | |
700 | 1 | |a Boesveldt, Sanne |e investigator |4 oth | |
700 | 1 | |a de Groot, Jasper H B |e investigator |4 oth | |
700 | 1 | |a Dinnella, Caterina |e investigator |4 oth | |
700 | 1 | |a Freiherr, Jessica |e investigator |4 oth | |
700 | 1 | |a Laktionova, Tatiana |e investigator |4 oth | |
700 | 1 | |a Marino, Sajidxa |e investigator |4 oth | |
700 | 1 | |a Monteleone, Erminio |e investigator |4 oth | |
700 | 1 | |a Nunez-Parra, Alexia |e investigator |4 oth | |
700 | 1 | |a Abdulrahman, Olagunju |e investigator |4 oth | |
700 | 1 | |a Ritchie, Marina |e investigator |4 oth | |
700 | 1 | |a Thomas-Danguin, Thierry |e investigator |4 oth | |
700 | 1 | |a Walsh-Messinger, Julie |e investigator |4 oth | |
700 | 1 | |a Al Abri, Rashid |e investigator |4 oth | |
700 | 1 | |a Alizadeh, Rafieh |e investigator |4 oth | |
700 | 1 | |a Bignon, Emmanuelle |e investigator |4 oth | |
700 | 1 | |a Cantone, Elena |e investigator |4 oth | |
700 | 1 | |a Paola Cecchini, Maria |e investigator |4 oth | |
700 | 1 | |a Chen, Jingguo |e investigator |4 oth | |
700 | 1 | |a Dolors Guàrdia, Maria |e investigator |4 oth | |
700 | 1 | |a Hoover, Kara C |e investigator |4 oth | |
700 | 1 | |a Karni, Noam |e investigator |4 oth | |
700 | 1 | |a Navarro, Marta |e investigator |4 oth | |
700 | 1 | |a Nolden, Alissa A |e investigator |4 oth | |
700 | 1 | |a Portillo Mazal, Patricia |e investigator |4 oth | |
700 | 1 | |a Rowan, Nicholas R |e investigator |4 oth | |
700 | 1 | |a Sarabi-Jamab, Atiye |e investigator |4 oth | |
700 | 1 | |a Archer, Nicholas S |e investigator |4 oth | |
700 | 1 | |a Chen, Ben |e investigator |4 oth | |
700 | 1 | |a Di Valerio, Elizabeth A |e investigator |4 oth | |
700 | 1 | |a Feeney, Emma L |e investigator |4 oth | |
700 | 1 | |a Frasnelli, Johannes |e investigator |4 oth | |
700 | 1 | |a Hannum, Mackenzie E |e investigator |4 oth | |
700 | 1 | |a Hopkins, Claire |e investigator |4 oth | |
700 | 1 | |a Klein, Hadar |e investigator |4 oth | |
700 | 1 | |a Mignot, Coralie |e investigator |4 oth | |
700 | 1 | |a Mucignat, Carla |e investigator |4 oth | |
700 | 1 | |a Ning, Yuping |e investigator |4 oth | |
700 | 1 | |a Ozturk, Elif E |e investigator |4 oth | |
700 | 1 | |a Peng, Mei |e investigator |4 oth | |
700 | 1 | |a Saatci, Ozlem |e investigator |4 oth | |
700 | 1 | |a Sell, Elizabeth A |e investigator |4 oth | |
700 | 1 | |a Yan, Carol H |e investigator |4 oth | |
700 | 1 | |a Alfaro, Raul |e investigator |4 oth | |
700 | 1 | |a Cecchetto, Cinzia |e investigator |4 oth | |
700 | 1 | |a Coureaud, Gérard |e investigator |4 oth | |
700 | 1 | |a Herriman, Riley D |e investigator |4 oth | |
700 | 1 | |a Justice, Jeb M |e investigator |4 oth | |
700 | 1 | |a Kaushik, Pavan Kumar |e investigator |4 oth | |
700 | 1 | |a Koyama, Sachiko |e investigator |4 oth | |
700 | 1 | |a Overdevest, Jonathan B |e investigator |4 oth | |
700 | 1 | |a Pirastu, Nicola |e investigator |4 oth | |
700 | 1 | |a Ramirez, Vicente A |e investigator |4 oth | |
700 | 1 | |a Roberts, S Craig |e investigator |4 oth | |
700 | 1 | |a Smith, Barry C |e investigator |4 oth | |
700 | 1 | |a Cao, Hongyuan |e investigator |4 oth | |
700 | 1 | |a Wang, Hong |e investigator |4 oth | |
700 | 1 | |a Balungwe Birindwa, Patrick |e investigator |4 oth | |
700 | 1 | |a Baguma, Marius |e investigator |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Chemical senses |d 1993 |g 46(2021) vom: 01. Jan. |w (DE-627)NLM074960482 |x 1464-3553 |7 nnns |
773 | 1 | 8 | |g volume:46 |g year:2021 |g day:01 |g month:01 |
856 | 4 | 0 | |u http://dx.doi.org/10.1093/chemse/bjaa081 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 46 |j 2021 |b 01 |c 01 |