Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA) : Evolving concept of CT findings, pathology and management
© 2020 The Authors..
The connective tissue diseases (CTDs) demonstrating features of interstitial lung disease (ILD) include systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), dermatomyositis (DM) and polymyositis (PM), ankylosing spondylitis (AS), Sjogren's syndrome (SS), and mixed connective tissue disease (MCTD). In RA patients in particular, interstitial lung abnormality (ILA) (of varying degrees; severe vs. mild) is reported to occur in approximately 20-60 % of individuals and CT disease progression occurs in approximately 35-45 % of them. The ILAs have been associated with a spectrum of functional and physiologic decrement. The identification of progressive ILA may enable appropriate surveillance and the commencement of treatment with the goal of improving morbidity and mortality rates of established RA-ILD. Subpleural distribution and higher baseline ILA/ILD extent were risk factors associated with disease progression. At histopathologic analysis, connective tissue disease-related interstitial lung diseases (CTD-ILDs) are diverse and include nonspecific interstitial pneumonia (NSIP), usual interstitial pneumonia (UIP), organizing pneumonia (OP), apical fibrosis, diffuse alveolar damage (DAD), and lymphoid interstitial pneumonia (LIP). Even though proportions of ILDs vary, NSIP pattern accounts for a large proportion, especially in PSS, DM/PM and MCTD, followed by UIP pattern. Evidence has been published that treatment of subclinical CT lung abnormalities showing a tendency to progress to ILD may stabilize the CT alterations. The identification of subclinical lung abnormalities can be appropriate in the management of the disease and CT appears to be the gold standard for the evaluation of lung parenchyma.
| Errataetall: |
RetractionIn: Eur J Radiol Open. 2022 Feb 11;9:100402. - PMID 36619809 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
European journal of radiology open - 8(2021) vom: 19., Seite 100311 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yoo, Hongseok [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 30.03.2024 published: Electronic-eCollection RetractionIn: Eur J Radiol Open. 2022 Feb 11;9:100402. - PMID 36619809 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.ejro.2020.100311 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319285685 |
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| 100 | 1 | |a Yoo, Hongseok |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA) |b Evolving concept of CT findings, pathology and management |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a RetractionIn: Eur J Radiol Open. 2022 Feb 11;9:100402. - PMID 36619809 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2020 The Authors. | ||
| 520 | |a The connective tissue diseases (CTDs) demonstrating features of interstitial lung disease (ILD) include systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), dermatomyositis (DM) and polymyositis (PM), ankylosing spondylitis (AS), Sjogren's syndrome (SS), and mixed connective tissue disease (MCTD). In RA patients in particular, interstitial lung abnormality (ILA) (of varying degrees; severe vs. mild) is reported to occur in approximately 20-60 % of individuals and CT disease progression occurs in approximately 35-45 % of them. The ILAs have been associated with a spectrum of functional and physiologic decrement. The identification of progressive ILA may enable appropriate surveillance and the commencement of treatment with the goal of improving morbidity and mortality rates of established RA-ILD. Subpleural distribution and higher baseline ILA/ILD extent were risk factors associated with disease progression. At histopathologic analysis, connective tissue disease-related interstitial lung diseases (CTD-ILDs) are diverse and include nonspecific interstitial pneumonia (NSIP), usual interstitial pneumonia (UIP), organizing pneumonia (OP), apical fibrosis, diffuse alveolar damage (DAD), and lymphoid interstitial pneumonia (LIP). Even though proportions of ILDs vary, NSIP pattern accounts for a large proportion, especially in PSS, DM/PM and MCTD, followed by UIP pattern. Evidence has been published that treatment of subclinical CT lung abnormalities showing a tendency to progress to ILD may stabilize the CT alterations. The identification of subclinical lung abnormalities can be appropriate in the management of the disease and CT appears to be the gold standard for the evaluation of lung parenchyma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Retracted Publication | |
| 650 | 4 | |a CTD, Connective tissue disease | |
| 650 | 4 | |a CTD-ILD, (Connective Tissue Disease-Related Interstitial Lung Disease) | |
| 650 | 4 | |a Connective tissue disease | |
| 650 | 4 | |a DM, Dermatomyositis | |
| 650 | 4 | |a IIP, Idiopathic interstitial pneumonia | |
| 650 | 4 | |a ILA, Interstitial lung abnormality | |
| 650 | 4 | |a ILD, Interstitial lung disease | |
| 650 | 4 | |a IPAF, Interstitial pneumonitis with autoimmune features | |
| 650 | 4 | |a IPF, Idiopathic pulmonary fibrosis | |
| 650 | 4 | |a Interstitial lung abnormality | |
| 650 | 4 | |a Interstitial lung disease | |
| 650 | 4 | |a MCTD, Mixed connective tissue disease | |
| 650 | 4 | |a NSIP, Nonspecific Interstitial Pneumonia | |
| 650 | 4 | |a OP, Organizing pneumonia | |
| 650 | 4 | |a PM, Polymyositis | |
| 650 | 4 | |a PSS, Progressive Systemic Sclerosis | |
| 650 | 4 | |a RA, Rheumatoid Arthritis | |
| 650 | 4 | |a SLE, Systemic Lupus Erythematosus | |
| 650 | 4 | |a SS, Sjogren’s Syndrome | |
| 650 | 4 | |a UCTD, Undifferentiated Connective Tissue Disease | |
| 650 | 4 | |a UIP, Usual Interstitial Pneumonia | |
| 700 | 1 | |a Hino, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Joungho |e verfasserin |4 aut | |
| 700 | 1 | |a Franks, Teri J |e verfasserin |4 aut | |
| 700 | 1 | |a Im, Yunjoo |e verfasserin |4 aut | |
| 700 | 1 | |a Hatabu, Hiroto |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Man Pyo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Kyung Soo |e verfasserin |4 aut | |
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