Tilapia viscera hydrolysate extract alleviates oxidative stress and renal damage in deoxycorticosterone acetate-salt-induced hypertension rats
Copyright: © Riyadi, et al..
BACKGROUND AND AIM: Hypertension is closely related to oxidative stress conditions, which increases malondialdehyde (MDA) expression and renal damage. Tilapia viscera hydrolysate extract (TVHE) contains compounds and peptides that act as antioxidants. This study aimed to investigate TVHE therapy effect on MDA levels and renal histological conditions in deoxycorticosterone acetate (DOCA)-salt-induced hypertension rats.
MATERIALS AND METHODS: Tilapia viscera were defatted and hydrolyzed using Alcalase enzyme to obtain TVHE. TVHE antioxidant activity was measured using the 1,1-diphenyl-2-picrylhydrazyl method. Fifteen Wistar male rats were divided into five groups: Normal control (without induced DOCA-salt), DOCA-salt, DOCA-salt+Captopril 5 mg/kg body weight (BW), DOCA-salt+TVHE 150 mg/kg BW, and DOCA-salt+TVHE 300 mg/kg BW. MDA level and renal histology were observed in each group.
RESULTS: TVHE half maximal inhibitory concentration values ranged from 3.87±0.35 μg/mL to 42.03±3.55 μg/mL, which were identified as in the very strong Blois category. TVHE and captopril therapy reduced MDA expression significantly (p<0.05) compared to DOCA-salt only. TVHE and captopril therapy also improved glomerular damage in DOCA-salt-induced hypertension rats.
CONCLUSION: TVHE has antioxidant ability, decreased MDA level, and decreased glomerular damage in DOCA-salt-induced hypertension rats.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Veterinary world - 13(2020), 11 vom: 19. Nov., Seite 2477-2483 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Riyadi, Putut Har [VerfasserIn] |
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| Anmerkungen: |
Date Revised 19.04.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.14202/vetworld.2020.2477-2483 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319276481 |
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| LEADER | 01000naa a22002652 4500 | ||
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| 100 | 1 | |a Riyadi, Putut Har |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tilapia viscera hydrolysate extract alleviates oxidative stress and renal damage in deoxycorticosterone acetate-salt-induced hypertension rats |
| 264 | 1 | |c 2020 | |
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| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 19.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright: © Riyadi, et al. | ||
| 520 | |a BACKGROUND AND AIM: Hypertension is closely related to oxidative stress conditions, which increases malondialdehyde (MDA) expression and renal damage. Tilapia viscera hydrolysate extract (TVHE) contains compounds and peptides that act as antioxidants. This study aimed to investigate TVHE therapy effect on MDA levels and renal histological conditions in deoxycorticosterone acetate (DOCA)-salt-induced hypertension rats | ||
| 520 | |a MATERIALS AND METHODS: Tilapia viscera were defatted and hydrolyzed using Alcalase enzyme to obtain TVHE. TVHE antioxidant activity was measured using the 1,1-diphenyl-2-picrylhydrazyl method. Fifteen Wistar male rats were divided into five groups: Normal control (without induced DOCA-salt), DOCA-salt, DOCA-salt+Captopril 5 mg/kg body weight (BW), DOCA-salt+TVHE 150 mg/kg BW, and DOCA-salt+TVHE 300 mg/kg BW. MDA level and renal histology were observed in each group | ||
| 520 | |a RESULTS: TVHE half maximal inhibitory concentration values ranged from 3.87±0.35 μg/mL to 42.03±3.55 μg/mL, which were identified as in the very strong Blois category. TVHE and captopril therapy reduced MDA expression significantly (p<0.05) compared to DOCA-salt only. TVHE and captopril therapy also improved glomerular damage in DOCA-salt-induced hypertension rats | ||
| 520 | |a CONCLUSION: TVHE has antioxidant ability, decreased MDA level, and decreased glomerular damage in DOCA-salt-induced hypertension rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a antioxidant | |
| 650 | 4 | |a hydrolysate | |
| 650 | 4 | |a peptide | |
| 650 | 4 | |a tilapia | |
| 650 | 4 | |a viscera | |
| 700 | 1 | |a Atho'illah, Mochammad Fitri |e verfasserin |4 aut | |
| 700 | 1 | |a Tanod, Wendy Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Rahmawati, Irma Sarita |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:13 |g year:2020 |g number:11 |g day:19 |g month:11 |g pages:2477-2483 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.14202/vetworld.2020.2477-2483 |3 Volltext |
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