Risk factors associated with valvular calcification in patients with chronic kidney disease. Analysis of NEFRONA Study
Copyright © 2020 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved..
INTRODUCTION: Patients with chronic kidney disease (CKD) are at high risk of cardiovascular morbidity and mortality. Subclinical cardiac structural alterations have prognostic value in these patients. The aim was to analyse the prevalence of valvular calcification, the evolution and the relationship with different risk factors.
MATERIAL AND METHODS: Part of the sample of the NEFRONA study was randomly selected. Aortic and mitral valve calcification were analysed in echocardiograms performed at the baseline visit and at 24 months.
RESULTS: We included 397 patients, the estimated basal glomerular filtrate (eGFR) was 33ml/min with significant decrease to 30.9ml/min. There was an increase in the area of carotid and femoral plaque, as well as an increase in patients with aortic and mitral calcification at 24 months. A positive association of mitral calcification at 24 months with age, ankle-brachial index (ABI) and calcium-phosphorus product (CaxP) at baseline visit was observed, without association with eGFR. Aortic calcification at 24 months was positively associated with age, phosphorous and total carotid plaque area at baseline, with no relationship to eGFR.
CONCLUSIONS: A significant prevalence of valvular calcification was observed in patients with CKD without known cardiovascular disease.Two-year progression was observed independently of the eGFR. Patients with higher risk of mitral valve calcification were those with older age, higher ABI and CaxP product. Patients with a higher risk of aortic calcification were those with older age, higher phosphorous levels and larger area of carotid plaque. Identifying these higher risk patients would help to avoid future cardiovascular events intensifying follow-ups.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Nefrologia - 41(2021), 3 vom: 20. Mai, Seite 337-346 |
| Sprache: |
Englisch |
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| Weiterer Titel: |
Factores de riesgo asociados a la calcificación valvular en pacientes con enfermedad renal crónica. Análisis del Estudio Nefrona |
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| Beteiligte Personen: |
Martínez Fernández, Lidia [VerfasserIn] |
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| Links: |
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| Themen: |
Calcificación valvular |
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| Anmerkungen: |
Date Completed 03.01.2022 Date Revised 03.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.nefro.2020.08.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319229602 |
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| 100 | 1 | |a Martínez Fernández, Lidia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk factors associated with valvular calcification in patients with chronic kidney disease. Analysis of NEFRONA Study |
| 246 | 3 | 3 | |a Factores de riesgo asociados a la calcificación valvular en pacientes con enfermedad renal crónica. Análisis del Estudio Nefrona |
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| 500 | |a Date Revised 03.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a INTRODUCTION: Patients with chronic kidney disease (CKD) are at high risk of cardiovascular morbidity and mortality. Subclinical cardiac structural alterations have prognostic value in these patients. The aim was to analyse the prevalence of valvular calcification, the evolution and the relationship with different risk factors | ||
| 520 | |a MATERIAL AND METHODS: Part of the sample of the NEFRONA study was randomly selected. Aortic and mitral valve calcification were analysed in echocardiograms performed at the baseline visit and at 24 months | ||
| 520 | |a RESULTS: We included 397 patients, the estimated basal glomerular filtrate (eGFR) was 33ml/min with significant decrease to 30.9ml/min. There was an increase in the area of carotid and femoral plaque, as well as an increase in patients with aortic and mitral calcification at 24 months. A positive association of mitral calcification at 24 months with age, ankle-brachial index (ABI) and calcium-phosphorus product (CaxP) at baseline visit was observed, without association with eGFR. Aortic calcification at 24 months was positively associated with age, phosphorous and total carotid plaque area at baseline, with no relationship to eGFR | ||
| 520 | |a CONCLUSIONS: A significant prevalence of valvular calcification was observed in patients with CKD without known cardiovascular disease.Two-year progression was observed independently of the eGFR. Patients with higher risk of mitral valve calcification were those with older age, higher ABI and CaxP product. Patients with a higher risk of aortic calcification were those with older age, higher phosphorous levels and larger area of carotid plaque. Identifying these higher risk patients would help to avoid future cardiovascular events intensifying follow-ups | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Calcificación valvular | |
| 650 | 4 | |a Chronic kidney disease Nefrona study | |
| 650 | 4 | |a Enfermedad renal crónica | |
| 650 | 4 | |a Estudio nefrona | |
| 650 | 4 | |a Factores de riesgo | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Valvular calcification | |
| 700 | 1 | |a Sánchez-Alvarez, J Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Morís de la Tassa, César |e verfasserin |4 aut | |
| 700 | 1 | |a Bande Fernández, José Joaquín |e verfasserin |4 aut | |
| 700 | 1 | |a María, Virtudes |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández, Elvira |e verfasserin |4 aut | |
| 700 | 1 | |a Valdivielso, José M |e verfasserin |4 aut | |
| 700 | 1 | |a Betriu, Angels |e verfasserin |4 aut | |
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