A Comprehensive Clinical Description of Pediatric SARS-CoV-2 Infection in Western Pennsylvania
Objective: We sought to characterize clinical presentation and healthcare utilization for pediatric COVID-19 in Western Pennsylvania (PA).
Methods: We established and analyzed a registry of pediatric COVID-19 in Western PA that includes cases in patients <22 years of age cared for by the pediatric quaternary medical center in the area and its associated pediatric primary care network from March 11 through August 20, 2020.
Results: Our cohort included 424 pediatric COVID-19 cases (mean age 12.5 years, 47.4% female); 65% reported exposure and 79% presented with symptoms. The most common initial healthcare contact was through telehealth (45%). Most cases were followed as outpatients, but twenty-two patients (4.5%) were hospitalized: 19 with acute COVID-19 disease, and three for multisystem inflammatory syndrome of children (MIS-C). Admitted patients were younger (p<0.001) and more likely to have pre-existing conditions (p<0.001). Black/Hispanic patients were 5.8 times more likely to be hospitalized than white patients (p=0.012). Five patients (1.2%) were admitted to the PICU, including all three MIS-C cases; two required BiPAP and one mechanical ventilation. All patients survived.
Conclusions: We provide a comprehensive snapshot of pediatric COVID-19 disease in an area with low to moderate incidence. In this cohort, COVID-19 was generally a mild disease; however, ~5% of children were hospitalized. Pediatric patients can be critically ill with this infection, including those presenting with MIS-C.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2020 |
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| Enthalten in: |
medRxiv : the preprint server for health sciences - (2020) vom: 16. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Freeman, Megan Culler [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 19.10.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1101/2020.12.14.20248192 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31919132X |
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| 100 | 1 | |a Freeman, Megan Culler |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A Comprehensive Clinical Description of Pediatric SARS-CoV-2 Infection in Western Pennsylvania |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 19.10.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Objective: We sought to characterize clinical presentation and healthcare utilization for pediatric COVID-19 in Western Pennsylvania (PA) | ||
| 520 | |a Methods: We established and analyzed a registry of pediatric COVID-19 in Western PA that includes cases in patients <22 years of age cared for by the pediatric quaternary medical center in the area and its associated pediatric primary care network from March 11 through August 20, 2020 | ||
| 520 | |a Results: Our cohort included 424 pediatric COVID-19 cases (mean age 12.5 years, 47.4% female); 65% reported exposure and 79% presented with symptoms. The most common initial healthcare contact was through telehealth (45%). Most cases were followed as outpatients, but twenty-two patients (4.5%) were hospitalized: 19 with acute COVID-19 disease, and three for multisystem inflammatory syndrome of children (MIS-C). Admitted patients were younger (p<0.001) and more likely to have pre-existing conditions (p<0.001). Black/Hispanic patients were 5.8 times more likely to be hospitalized than white patients (p=0.012). Five patients (1.2%) were admitted to the PICU, including all three MIS-C cases; two required BiPAP and one mechanical ventilation. All patients survived | ||
| 520 | |a Conclusions: We provide a comprehensive snapshot of pediatric COVID-19 disease in an area with low to moderate incidence. In this cohort, COVID-19 was generally a mild disease; however, ~5% of children were hospitalized. Pediatric patients can be critically ill with this infection, including those presenting with MIS-C | ||
| 650 | 4 | |a Preprint | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a MIS-C | |
| 650 | 4 | |a Pediatrics | |
| 700 | 1 | |a Gaietto, Kristina |e verfasserin |4 aut | |
| 700 | 1 | |a DiCicco, Leigh Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Rauenswinter, Sherry |e verfasserin |4 aut | |
| 700 | 1 | |a Squire, Joseph R |e verfasserin |4 aut | |
| 700 | 1 | |a Aldewereld, Zachary |e verfasserin |4 aut | |
| 700 | 1 | |a Rapsinski, Glenn |e verfasserin |4 aut | |
| 700 | 1 | |a Iagnemma, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Campfield, Brian T |e verfasserin |4 aut | |
| 700 | 1 | |a Wolfson, David |e verfasserin |4 aut | |
| 700 | 1 | |a Kazmerski, Traci M |e verfasserin |4 aut | |
| 700 | 1 | |a Forno, Erick |e verfasserin |4 aut | |
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