Short-Term Intake of Hesperetin-7-O-Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice
Hesperetin-7-O-glucoside (Hes-7-G) is a typical flavonoid monoglucoside isolated from Citri Reticulatae Pericarpium (CRP), which is commonly used as a food adjuvant and exhibits potential biological activities. To explore the interaction between Hes-7-G ingestion and microbiome and host metabolism, here, 16S rRNA gene sequencing was first used to analyze the alteration of fecal microbiome in mice after Hes-7-G intake. Metabolic homeostasis in mice was subsequently investigated using untargeted 1H NMR-based metabolomics and targeted metabolite profiling. We found that dietary Hes-7-G significantly regulated fecal microbiota and its derived metabolites, including short-chain fatty acids (SCFAs) and tryptophan metabolites (indole and its derivatives), in feces of mice. Regulation of microbiota was further confirmed by the significantly changed urinary hippurate and trimethylamine N-oxide (TMAO), co-metabolites of the microbe and host. We also found that dietary Hes-7-G modulated the host tricarboxylic acid cycle (TCA) involved in energy metabolism. These findings suggested that Hes-7-G exhibits potential beneficial effects for human health.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:69 |
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| Enthalten in: |
Journal of agricultural and food chemistry - 69(2021), 5 vom: 10. Feb., Seite 1478-1486 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Fang [VerfasserIn] |
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| Links: |
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| Themen: |
Bioactivity |
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| Anmerkungen: |
Date Completed 16.04.2021 Date Revised 16.04.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acs.jafc.0c05921 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM319161420 |
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| 520 | |a Hesperetin-7-O-glucoside (Hes-7-G) is a typical flavonoid monoglucoside isolated from Citri Reticulatae Pericarpium (CRP), which is commonly used as a food adjuvant and exhibits potential biological activities. To explore the interaction between Hes-7-G ingestion and microbiome and host metabolism, here, 16S rRNA gene sequencing was first used to analyze the alteration of fecal microbiome in mice after Hes-7-G intake. Metabolic homeostasis in mice was subsequently investigated using untargeted 1H NMR-based metabolomics and targeted metabolite profiling. We found that dietary Hes-7-G significantly regulated fecal microbiota and its derived metabolites, including short-chain fatty acids (SCFAs) and tryptophan metabolites (indole and its derivatives), in feces of mice. Regulation of microbiota was further confirmed by the significantly changed urinary hippurate and trimethylamine N-oxide (TMAO), co-metabolites of the microbe and host. We also found that dietary Hes-7-G modulated the host tricarboxylic acid cycle (TCA) involved in energy metabolism. These findings suggested that Hes-7-G exhibits potential beneficial effects for human health | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a hesperetin-7-O-glucoside | |
| 650 | 4 | |a host metabolism | |
| 650 | 4 | |a microbiome | |
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| 700 | 1 | |a Shi, Zunji |e verfasserin |4 aut | |
| 700 | 1 | |a Lei, Hehua |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Gui |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Peihong |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Zheng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Xuehang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Caixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Manyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Yuchen |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Yangyang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Jinlin |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Yujing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Limin |e verfasserin |4 aut | |
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