Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China
Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10-3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Emerging infectious diseases - 27(2021), 1 vom: 01. Jan., Seite 196-204 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Leung, Kenneth Siu-Sing [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.01.2021 Date Revised 11.01.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.3201/eid2701.201543 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319155188 |
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| 520 | |a Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10-3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread | ||
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| 650 | 4 | |a severe acute respiratory syndrome coronavirus 2 | |
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| 700 | 1 | |a Yau, Miranda Chong-Yee |e verfasserin |4 aut | |
| 700 | 1 | |a Lao, Hiu-Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Ming-Pan |e verfasserin |4 aut | |
| 700 | 1 | |a Tam, Kingsley King-Gee |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Lam-Kwong |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Barry Kin-Chung |e verfasserin |4 aut | |
| 700 | 1 | |a Man Ho, Alex Yat |e verfasserin |4 aut | |
| 700 | 1 | |a Yip, Kam-Tong |e verfasserin |4 aut | |
| 700 | 1 | |a Lung, Kwok-Cheung |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Raymond Wai-To |e verfasserin |4 aut | |
| 700 | 1 | |a Tso, Eugene Yuk-Keung |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Wai-Shing |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Man-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Yuk-Yung |e verfasserin |4 aut | |
| 700 | 1 | |a Sin, Kit-Man |e verfasserin |4 aut | |
| 700 | 1 | |a Fung, Kitty Sau-Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Chau, Sandy Ka-Yee |e verfasserin |4 aut | |
| 700 | 1 | |a To, Wing-Kin |e verfasserin |4 aut | |
| 700 | 1 | |a Que, Tak-Lun |e verfasserin |4 aut | |
| 700 | 1 | |a Shum, David Ho-Keung |e verfasserin |4 aut | |
| 700 | 1 | |a Yip, Shea Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Yam, Wing Cheong |e verfasserin |4 aut | |
| 700 | 1 | |a Siu, Gilman Kit-Hang |e verfasserin |4 aut | |
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