Stressin' and slicin' : stress-induced tRNA fragmentation codon-adapts translation to repress cell growth
© 2020 The Authors..
Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNAGUA fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells.
| Errataetall: |
CommentOn: EMBO J. 2021 Jan 15;40(2):e106696. - PMID 33346941 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
The EMBO journal - 40(2021), 2 vom: 15. Jan., Seite e107097 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Guzzi, Nicola [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 14.04.2021 Date Revised 16.01.2022 published: Print-Electronic CommentOn: EMBO J. 2021 Jan 15;40(2):e106696. - PMID 33346941 Citation Status MEDLINE |
|---|
| doi: |
10.15252/embj.2020107097 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM319117286 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM319117286 | ||
| 003 | DE-627 | ||
| 005 | 20231225170755.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/embj.2020107097 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1063.xml |
| 035 | |a (DE-627)NLM319117286 | ||
| 035 | |a (NLM)33346912 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Guzzi, Nicola |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Stressin' and slicin' |b stress-induced tRNA fragmentation codon-adapts translation to repress cell growth |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.04.2021 | ||
| 500 | |a Date Revised 16.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentOn: EMBO J. 2021 Jan 15;40(2):e106696. - PMID 33346941 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Authors. | ||
| 520 | |a Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNAGUA fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells | ||
| 650 | 4 | |a News | |
| 650 | 4 | |a Comment | |
| 650 | 7 | |a Codon |2 NLM | |
| 650 | 7 | |a Tyrosine |2 NLM | |
| 650 | 7 | |a 42HK56048U |2 NLM | |
| 650 | 7 | |a RNA, Transfer |2 NLM | |
| 650 | 7 | |a 9014-25-9 |2 NLM | |
| 700 | 1 | |a Bellodi, Cristian |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The EMBO journal |d 1982 |g 40(2021), 2 vom: 15. Jan., Seite e107097 |w (DE-627)NLM012617202 |x 1460-2075 |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2021 |g number:2 |g day:15 |g month:01 |g pages:e107097 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.15252/embj.2020107097 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 40 |j 2021 |e 2 |b 15 |c 01 |h e107097 | ||