Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression.
METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression.
RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression.
CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Revista da Sociedade Brasileira de Medicina Tropical - 54(2020) vom: 21., Seite e01452020 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Oliveira, Saulo Gomes de [VerfasserIn] |
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| Anmerkungen: |
Date Completed 22.12.2020 Date Revised 23.12.2020 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1590/0037-8682-0145-2020 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM319030253 |
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| 100 | 1 | |a Oliveira, Saulo Gomes de |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 22.12.2020 | ||
| 500 | |a Date Revised 23.12.2020 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression | ||
| 520 | |a METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression | ||
| 520 | |a RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression | ||
| 520 | |a CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Mannose-Binding Lectin |2 NLM | |
| 700 | 1 | |a Souza, Ilana Brito Ferraz de |e verfasserin |4 aut | |
| 700 | 1 | |a Constantino, Taynan da Silva |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Paula Carolina Valença |e verfasserin |4 aut | |
| 700 | 1 | |a Lima, Elker Lene Santos de |e verfasserin |4 aut | |
| 700 | 1 | |a Muniz, Maria Tereza Cartaxo |e verfasserin |4 aut | |
| 700 | 1 | |a Domingues, Ana Lúcia Coutinho |e verfasserin |4 aut | |
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