Persistent Cellular Immunity to SARS-CoV-2 Infection
SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4 + and CD8 + T cells, expression of activation/exhaustion markers, and cell division.
SUMMARY: We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4 + and CD8 + T cells compartments.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2020 |
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| Enthalten in: |
bioRxiv : the preprint server for biology - (2020) vom: 09. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Breton, Gaëlle [VerfasserIn] |
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Date Revised 30.03.2024 published: Electronic UpdateIn: J Exp Med. 2021 Apr 5;218(4):. - PMID 33533915 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1101/2020.12.08.416636 |
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| PPN (Katalog-ID): |
NLM318959194 |
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| 500 | |a published: Electronic | ||
| 500 | |a UpdateIn: J Exp Med. 2021 Apr 5;218(4):. - PMID 33533915 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4 + and CD8 + T cells, expression of activation/exhaustion markers, and cell division | ||
| 520 | |a SUMMARY: We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4 + and CD8 + T cells compartments | ||
| 650 | 4 | |a Preprint | |
| 700 | 1 | |a Mendoza, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Hagglof, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Thiago Y |e verfasserin |4 aut | |
| 700 | 1 | |a Schaefer-Babajew, Dennis |e verfasserin |4 aut | |
| 700 | 1 | |a Gaebler, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Turroja, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Hurley, Arlene |e verfasserin |4 aut | |
| 700 | 1 | |a Caskey, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Nussenzweig, Michel C |e verfasserin |4 aut | |
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