An Elusive Prize : Transcutaneous Near InfraRed Spectroscopy (NIRS) Monitoring of the Liver
Copyright © 2020 Guyon, Karamlou, Ratnayaka, El-Said, Moore and Rao..
Introduction: We postulate a relationship between a transcutaneous hepatic NIRS measurement and a directly obtained hepatic vein saturation. If true, hepatic NIRS monitoring (in conjunction with the current dual-site cerebral-renal NIRS paradigm) might increase the sensitivity for detecting shock since regional oxygen delivery changes in the splanchnic circulation before the kidney or brain. We explored a reliable technique for hepatic NIRS monitoring as a prelude to rigorously testing this hypothesis. This proof-of-concept study aimed to validate hepatic NIRS monitoring by comparing hepatic NIRS measurements to direct hepatic vein samples obtained during cardiac catheterization. Method: IRB-approved prospective pilot study of hepatic NIRS monitoring involving 10 patients without liver disease who were already undergoing elective cardiac catheterization. We placed a NIRS monitor on the skin overlying liver during catheterization. Direct measurement of hepatic vein oxygen saturation during the case compared with simultaneous hepatic NIRS measurement. Results: There was no correlation between the Hepatic NIRS values and the directly measured hepatic vein saturation (R = -0.035; P = 0.9238). However, the Hepatic NIRS values correlated with the cardiac output (R = 0.808; P = 0.0047), the systolic arterial blood pressure (R = 0.739; P = 0.0146), and the diastolic arterial blood pressure (R = 0.7548; P = 0.0116). Conclusions: Using the technique described, hepatic NIRS does not correlate well with the hepatic vein saturation. Further optimization of the technique might provide a better measurement. Hepatic NIRS does correlate with cardiac output and thus may still provide a valuable additional piece of hemodynamic information when combined with other non-invasive monitoring.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Frontiers in pediatrics - 8(2020) vom: 13., Seite 563483 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guyon, Peter W [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiac output (CO) |
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| Anmerkungen: |
Date Revised 18.12.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fped.2020.563483 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31895317X |
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| 100 | 1 | |a Guyon, Peter W |c Jr |e verfasserin |4 aut | |
| 245 | 1 | 3 | |a An Elusive Prize |b Transcutaneous Near InfraRed Spectroscopy (NIRS) Monitoring of the Liver |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Revised 18.12.2020 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2020 Guyon, Karamlou, Ratnayaka, El-Said, Moore and Rao. | ||
| 520 | |a Introduction: We postulate a relationship between a transcutaneous hepatic NIRS measurement and a directly obtained hepatic vein saturation. If true, hepatic NIRS monitoring (in conjunction with the current dual-site cerebral-renal NIRS paradigm) might increase the sensitivity for detecting shock since regional oxygen delivery changes in the splanchnic circulation before the kidney or brain. We explored a reliable technique for hepatic NIRS monitoring as a prelude to rigorously testing this hypothesis. This proof-of-concept study aimed to validate hepatic NIRS monitoring by comparing hepatic NIRS measurements to direct hepatic vein samples obtained during cardiac catheterization. Method: IRB-approved prospective pilot study of hepatic NIRS monitoring involving 10 patients without liver disease who were already undergoing elective cardiac catheterization. We placed a NIRS monitor on the skin overlying liver during catheterization. Direct measurement of hepatic vein oxygen saturation during the case compared with simultaneous hepatic NIRS measurement. Results: There was no correlation between the Hepatic NIRS values and the directly measured hepatic vein saturation (R = -0.035; P = 0.9238). However, the Hepatic NIRS values correlated with the cardiac output (R = 0.808; P = 0.0047), the systolic arterial blood pressure (R = 0.739; P = 0.0146), and the diastolic arterial blood pressure (R = 0.7548; P = 0.0116). Conclusions: Using the technique described, hepatic NIRS does not correlate well with the hepatic vein saturation. Further optimization of the technique might provide a better measurement. Hepatic NIRS does correlate with cardiac output and thus may still provide a valuable additional piece of hemodynamic information when combined with other non-invasive monitoring | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cardiac output (CO) | |
| 650 | 4 | |a congenital heart disease | |
| 650 | 4 | |a near-infra read spectroscopy | |
| 650 | 4 | |a non-invasive monitoring | |
| 650 | 4 | |a regional oximetry | |
| 650 | 4 | |a shock | |
| 700 | 1 | |a Karamlou, Tara |e verfasserin |4 aut | |
| 700 | 1 | |a Ratnayaka, Kanishka |e verfasserin |4 aut | |
| 700 | 1 | |a El-Said, Howaida G |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, John W |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Rohit P |e verfasserin |4 aut | |
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