A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019
With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) all over the world, there is an increasing number of children with such infection. Angiotensin-converting enzyme 2 (ACE2), one of the binding sites for SARS-CoV-2 infection in humans, can bind to viral spike proteins, allowing transmembrane serine protease (TMPRSS2) to activate S-protein to trigger infection and induce the production of various inflammatory factors such as interleukin-1, interferon-l, and tumor necrosis factor. Compared with adults, children tend to have lower expression levels of ACE2 and TMPRSS2, which are presumed to be associated with milder symptoms and fewer cases in children. The article summarizes the research advances in the role of ACE2 during SARS-CoV-2 infection, in order to help understand the pathogenic mechanism of SARS-CoV-2 and provide a reference for better development of drugs and vaccines to prevent and treat coronavirus disease 2019 in children.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 22(2020), 12 vom: 17. Dez., Seite 1344-1348 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Liu, Jing [VerfasserIn] |
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| Themen: |
ACE2 protein, human |
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| Anmerkungen: |
Date Completed 21.12.2020 Date Revised 04.11.2023 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM318930706 |
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| 100 | 1 | |a Liu, Jing |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019 |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 21.12.2020 | ||
| 500 | |a Date Revised 04.11.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) all over the world, there is an increasing number of children with such infection. Angiotensin-converting enzyme 2 (ACE2), one of the binding sites for SARS-CoV-2 infection in humans, can bind to viral spike proteins, allowing transmembrane serine protease (TMPRSS2) to activate S-protein to trigger infection and induce the production of various inflammatory factors such as interleukin-1, interferon-l, and tumor necrosis factor. Compared with adults, children tend to have lower expression levels of ACE2 and TMPRSS2, which are presumed to be associated with milder symptoms and fewer cases in children. The article summarizes the research advances in the role of ACE2 during SARS-CoV-2 infection, in order to help understand the pathogenic mechanism of SARS-CoV-2 and provide a reference for better development of drugs and vaccines to prevent and treat coronavirus disease 2019 in children | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a ACE2 protein, human |2 NLM | |
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| 700 | 1 | |a Chen, Guo-Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Jiao, Fu-Yong |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics |d 2006 |g 22(2020), 12 vom: 17. Dez., Seite 1344-1348 |w (DE-627)NLM161132898 |x 1008-8830 |7 nnns |
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