Multiple myeloma with light chain deposition disease showing needle-like crystal inclusions in plasma cells and macrophages in multiple organs
A 57-year-old Japanese man was referred to our hospital with the chief complaint of dizziness. Our investigations showed pancytopenia that necessitated bone marrow evaluation; this evaluation revealed plasma cell proliferation that was accompanied by numerous needle-shaped crystal inclusions. Clinical and laboratory examinations were used to establish a diagnosis of multiple myeloma (MM) accompanied by Fanconi syndrome. He was administered treatment with bortezomib, lenalidomide, or thalidomide; however, he died after experiencing upper abdominal pain of unknown etiology. Histopathological examination showed needle-like inclusions in the liver and kidney and macrophages in the bone marrow, suggesting light chain deposition disease (LCDD) that could contribute to multi-organ injury. We report the rare case of a patient with needle-shaped inclusions in MM that caused LCDD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Rinsho ketsueki] The Japanese journal of clinical hematology - 61(2020), 11 vom: 24., Seite 1620-1624 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Ohara, Shin [VerfasserIn] |
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| Links: |
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| Themen: |
4Z8R6ORS6L |
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| Anmerkungen: |
Date Completed 02.02.2021 Date Revised 02.02.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.11406/rinketsu.61.1620 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM318641097 |
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| 520 | |a A 57-year-old Japanese man was referred to our hospital with the chief complaint of dizziness. Our investigations showed pancytopenia that necessitated bone marrow evaluation; this evaluation revealed plasma cell proliferation that was accompanied by numerous needle-shaped crystal inclusions. Clinical and laboratory examinations were used to establish a diagnosis of multiple myeloma (MM) accompanied by Fanconi syndrome. He was administered treatment with bortezomib, lenalidomide, or thalidomide; however, he died after experiencing upper abdominal pain of unknown etiology. Histopathological examination showed needle-like inclusions in the liver and kidney and macrophages in the bone marrow, suggesting light chain deposition disease (LCDD) that could contribute to multi-organ injury. We report the rare case of a patient with needle-shaped inclusions in MM that caused LCDD | ||
| 650 | 4 | |a Case Reports | |
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| 650 | 4 | |a Crystal inclusion | |
| 650 | 4 | |a Fanconi syndrome | |
| 650 | 4 | |a Light chain deposition disease | |
| 650 | 4 | |a Multiple myeloma | |
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| 700 | 1 | |a Ide, Shiro |e verfasserin |4 aut | |
| 700 | 1 | |a Uchida, Tomoyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Morihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hua, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Hagihara, Masao |e verfasserin |4 aut | |
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