Ureaplasma-Driven Neuroinflammation in Neonates : Assembling the Puzzle Pieces
© 2020 The Author(s) Published by S. Karger AG, Basel..
Ureaplasma species (spp.) are commonly regarded as low-virulence colonizers of the genitourinary tract. Intrauterine Ureaplasma infection, however, has been associated with chorioamnionitis and preterm birth. The overall impact of a neonatal Ureaplasma colonization is yet to be understood. High pathogen prevalence and frequent neurological morbidities particularly in immature preterm infants call for an assessment of the significance of Ureaplasma spp. in neonatal neuroinflammation. This narrative review summarizes clinical data, animal studies, and in vitro results to elucidate potential Ureaplasma-associated neurological morbidities as well as underlying mechanisms. Increasing evidence indicates an involvement of Ureaplasma spp. in invasive central nervous system infections, suggesting a meticulous ability of Ureaplasma spp. to interfere with immune defense mechanisms. Ultimately, Ureaplasma spp. should be considered as relevant pathogens in neonatal neuroinflammation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:117 |
|---|---|
| Enthalten in: |
Neonatology - 117(2020), 6 vom: 23., Seite 665-672 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Silwedel, Christine [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 31.08.2021 Date Revised 31.08.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1159/000512019 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM318376911 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM318376911 | ||
| 003 | DE-627 | ||
| 005 | 20231225165228.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000512019 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1061.xml |
| 035 | |a (DE-627)NLM318376911 | ||
| 035 | |a (NLM)33271546 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Silwedel, Christine |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ureaplasma-Driven Neuroinflammation in Neonates |b Assembling the Puzzle Pieces |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.08.2021 | ||
| 500 | |a Date Revised 31.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020 The Author(s) Published by S. Karger AG, Basel. | ||
| 520 | |a Ureaplasma species (spp.) are commonly regarded as low-virulence colonizers of the genitourinary tract. Intrauterine Ureaplasma infection, however, has been associated with chorioamnionitis and preterm birth. The overall impact of a neonatal Ureaplasma colonization is yet to be understood. High pathogen prevalence and frequent neurological morbidities particularly in immature preterm infants call for an assessment of the significance of Ureaplasma spp. in neonatal neuroinflammation. This narrative review summarizes clinical data, animal studies, and in vitro results to elucidate potential Ureaplasma-associated neurological morbidities as well as underlying mechanisms. Increasing evidence indicates an involvement of Ureaplasma spp. in invasive central nervous system infections, suggesting a meticulous ability of Ureaplasma spp. to interfere with immune defense mechanisms. Ultimately, Ureaplasma spp. should be considered as relevant pathogens in neonatal neuroinflammation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Neonates | |
| 650 | 4 | |a Neuroinflammation | |
| 650 | 4 | |a Preterm infants | |
| 650 | 4 | |a Ureaplasma parvum | |
| 650 | 4 | |a Ureaplasma urealyticum | |
| 700 | 1 | |a Speer, Christian P |e verfasserin |4 aut | |
| 700 | 1 | |a Härtel, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Glaser, Kirsten |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neonatology |d 2007 |g 117(2020), 6 vom: 23., Seite 665-672 |w (DE-627)NLM168829339 |x 1661-7819 |7 nnns |
| 773 | 1 | 8 | |g volume:117 |g year:2020 |g number:6 |g day:23 |g pages:665-672 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1159/000512019 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 117 |j 2020 |e 6 |b 23 |h 665-672 | ||