Examination of Analytical Methods for Methanol, Trichloroethylene, and Tetrachloroethylene to Revise the Official Methods Based on the Act on the Control of Household Products Containing Harmful Substances
In Japan, the use of methanol, trichloroethylene, and tetrachloroethylene in aerosol household products is banned under the Act on the Control of Household Products Containing Harmful Substances. As the official analytical methods for testing for these substances have not been revised for over 35 years, several issues have been pointed out. Thus, we developed a new method to revise the official method in our previous study. In this study, validation of the proposed method for detecting the target substances was conducted using two aerosol-product samples (A and B), which contained methanol, trichloroethylene, and tetrachloroethylene. Sample A comprised regulated values of these compounds, while sample B comprised one-tenth of the regulated amounts. They also contained several volatile compounds that served as interfering substances. Subsequently, the samples were analyzed using head space/gas chromatography-mass spectrometry, and it was confirmed that the three target substances were separated from the other chemicals on chromatograms. Validation tests were conducted at seven laboratories to evaluate the proposed method using the prepared samples. In one laboratory, the recovery of trichloroethylene and tetrachloroethylene in sample B was slightly higher at 120%, while the recoveries obtained from the other tests were between 70% and 120%. Relative standard deviation at each laboratory was less than 10%. Furthermore, the relative standard deviations between the validation tests with respect to each chemical were less than 15%. Therefore, the method validated in this study was considered to be effective as a revised method for testing for methanol, trichloroethylene, and trichloroethylene in household aerosol products.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:140 |
|---|---|
| Enthalten in: |
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 140(2020), 12 vom: 13., Seite 1485-1494 |
| Sprache: |
Japanisch |
|---|
| Beteiligte Personen: |
Kawakami, Tsuyoshi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
290YE8AR51 |
|---|
| Anmerkungen: |
Date Completed 11.12.2020 Date Revised 14.12.2020 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1248/yakushi.20-00163 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM318348551 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM318348551 | ||
| 003 | DE-627 | ||
| 005 | 20231225165153.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||jpn c | ||
| 024 | 7 | |a 10.1248/yakushi.20-00163 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1061.xml |
| 035 | |a (DE-627)NLM318348551 | ||
| 035 | |a (NLM)33268689 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a jpn | ||
| 100 | 1 | |a Kawakami, Tsuyoshi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Examination of Analytical Methods for Methanol, Trichloroethylene, and Tetrachloroethylene to Revise the Official Methods Based on the Act on the Control of Household Products Containing Harmful Substances |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.12.2020 | ||
| 500 | |a Date Revised 14.12.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In Japan, the use of methanol, trichloroethylene, and tetrachloroethylene in aerosol household products is banned under the Act on the Control of Household Products Containing Harmful Substances. As the official analytical methods for testing for these substances have not been revised for over 35 years, several issues have been pointed out. Thus, we developed a new method to revise the official method in our previous study. In this study, validation of the proposed method for detecting the target substances was conducted using two aerosol-product samples (A and B), which contained methanol, trichloroethylene, and tetrachloroethylene. Sample A comprised regulated values of these compounds, while sample B comprised one-tenth of the regulated amounts. They also contained several volatile compounds that served as interfering substances. Subsequently, the samples were analyzed using head space/gas chromatography-mass spectrometry, and it was confirmed that the three target substances were separated from the other chemicals on chromatograms. Validation tests were conducted at seven laboratories to evaluate the proposed method using the prepared samples. In one laboratory, the recovery of trichloroethylene and tetrachloroethylene in sample B was slightly higher at 120%, while the recoveries obtained from the other tests were between 70% and 120%. Relative standard deviation at each laboratory was less than 10%. Furthermore, the relative standard deviations between the validation tests with respect to each chemical were less than 15%. Therefore, the method validated in this study was considered to be effective as a revised method for testing for methanol, trichloroethylene, and trichloroethylene in household aerosol products | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a head space (HS)-GC/MS | |
| 650 | 4 | |a household aerosol product | |
| 650 | 4 | |a methanol | |
| 650 | 4 | |a tetrachloroethylene | |
| 650 | 4 | |a trichloroethylene | |
| 650 | 7 | |a Aerosols |2 NLM | |
| 650 | 7 | |a Trichloroethylene |2 NLM | |
| 650 | 7 | |a 290YE8AR51 |2 NLM | |
| 650 | 7 | |a Tetrachloroethylene |2 NLM | |
| 650 | 7 | |a TJ904HH8SN |2 NLM | |
| 650 | 7 | |a Methanol |2 NLM | |
| 650 | 7 | |a Y4S76JWI15 |2 NLM | |
| 700 | 1 | |a Sugaya, Naeko |e verfasserin |4 aut | |
| 700 | 1 | |a Tahara, Maiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ooshima, Tomoko |e verfasserin |4 aut | |
| 700 | 1 | |a Nishi, Iwaki |e verfasserin |4 aut | |
| 700 | 1 | |a Uemura, Hitoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Shioda, Hiroko |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Ikuo |e verfasserin |4 aut | |
| 700 | 1 | |a Tabata, Kayo |e verfasserin |4 aut | |
| 700 | 1 | |a Ikarashi, Yoshiaki |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan |d 1961 |g 140(2020), 12 vom: 13., Seite 1485-1494 |w (DE-627)NLM000042153 |x 1347-5231 |7 nnns |
| 773 | 1 | 8 | |g volume:140 |g year:2020 |g number:12 |g day:13 |g pages:1485-1494 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1248/yakushi.20-00163 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 140 |j 2020 |e 12 |b 13 |h 1485-1494 | ||