Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm
Copyright © 2020 Elsevier Inc. All rights reserved..
OBJECTIVE: To identify perinatal clinical diseases and treatments that are associated with the development of objectively diagnosed diffuse white matter abnormality (DWMA) on structural magnetic resonance imaging (MRI) at term-equivalent age in infants born very preterm.
STUDY DESIGN: A prospective cohort of 392 infants born very preterm (≤32 weeks of gestational age) was enrolled from 5 level III/IV neonatal intensive care units between September 2016 and November 2019. MRIs of the brain were collected at 39 to 45 weeks of postmenstrual age to evaluate DWMA volume. A predefined list of pertinent maternal characteristics, pregnancy/delivery data, and neonatal intensive care unit data were collected for enrolled patients to identify antecedents of objectively diagnosed DWMA.
RESULTS: Of the 392 infants in the cohort, 377 (96%) had high-quality MRI data. Their mean (SD) gestational age was 29.3 (2.5) weeks. In multivariable linear regression analyses, pneumothorax (P = .027), severe bronchopulmonary dysplasia (BPD) (P = .009), severe retinopathy of prematurity (P < .001), and male sex (P = .041) were associated with increasing volume of DWMA. The following factors were associated with decreased risk of DWMA: postnatal dexamethasone therapy for severe BPD (P = .004), duration of caffeine therapy for severe BPD (P = .009), and exclusive maternal milk diet at neonatal intensive care unit discharge (P = .049).
CONCLUSIONS: Severe retinopathy of prematurity and BPD exhibited the strongest adverse association with development of DWMA. We also identified treatments and nutritional factors that appear protective against the development of DWMA that also have implications for the clinical care of infants born very preterm.
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:233 |
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| Enthalten in: |
The Journal of pediatrics - 233(2021) vom: 10. Juni, Seite 58-65.e3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Parikh, Nehal A [VerfasserIn] |
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| Links: |
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3G6A5W338E |
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| Anmerkungen: |
Date Completed 23.08.2021 Date Revised 16.07.2022 published: Print-Electronic CommentIn: J Pediatr. 2021 Jan 7;:. - PMID 33422581 Citation Status MEDLINE |
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| doi: |
10.1016/j.jpeds.2020.11.058 |
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| PPN (Katalog-ID): |
NLM318261650 |
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| 100 | 1 | |a Parikh, Nehal A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 23.08.2021 | ||
| 500 | |a Date Revised 16.07.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Pediatr. 2021 Jan 7;:. - PMID 33422581 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To identify perinatal clinical diseases and treatments that are associated with the development of objectively diagnosed diffuse white matter abnormality (DWMA) on structural magnetic resonance imaging (MRI) at term-equivalent age in infants born very preterm | ||
| 520 | |a STUDY DESIGN: A prospective cohort of 392 infants born very preterm (≤32 weeks of gestational age) was enrolled from 5 level III/IV neonatal intensive care units between September 2016 and November 2019. MRIs of the brain were collected at 39 to 45 weeks of postmenstrual age to evaluate DWMA volume. A predefined list of pertinent maternal characteristics, pregnancy/delivery data, and neonatal intensive care unit data were collected for enrolled patients to identify antecedents of objectively diagnosed DWMA | ||
| 520 | |a RESULTS: Of the 392 infants in the cohort, 377 (96%) had high-quality MRI data. Their mean (SD) gestational age was 29.3 (2.5) weeks. In multivariable linear regression analyses, pneumothorax (P = .027), severe bronchopulmonary dysplasia (BPD) (P = .009), severe retinopathy of prematurity (P < .001), and male sex (P = .041) were associated with increasing volume of DWMA. The following factors were associated with decreased risk of DWMA: postnatal dexamethasone therapy for severe BPD (P = .004), duration of caffeine therapy for severe BPD (P = .009), and exclusive maternal milk diet at neonatal intensive care unit discharge (P = .049) | ||
| 520 | |a CONCLUSIONS: Severe retinopathy of prematurity and BPD exhibited the strongest adverse association with development of DWMA. We also identified treatments and nutritional factors that appear protective against the development of DWMA that also have implications for the clinical care of infants born very preterm | ||
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| 700 | 1 | |a He, Lili |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hailong |e verfasserin |4 aut | |
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| 700 | 1 | |a Cahill, Tanya |e investigator |4 oth | |
| 700 | 1 | |a Cecil, Kim |e investigator |4 oth | |
| 700 | 1 | |a Dietrich, Kent |e investigator |4 oth | |
| 700 | 1 | |a Distler, Christen |e investigator |4 oth | |
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| 700 | 1 | |a Georg, Brianne |e investigator |4 oth | |
| 700 | 1 | |a Grisby, Cathy |e investigator |4 oth | |
| 700 | 1 | |a Haas, Lacey |e investigator |4 oth | |
| 700 | 1 | |a Harpster, Karen |e investigator |4 oth | |
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| 700 | 1 | |a Kline-Fath, Beth M |e investigator |4 oth | |
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