Definitive radiotherapy in patients of synchronous esophageal and head and neck cancer-treatment outcome and toxicity
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved..
AIM: The aim is to retrospectively evaluate the clinical outcomes and treatment related toxicities in patients of synchronous esophageal and head & neck cancer when treated with definitive radiotherapy with or without concurrent chemotherapy.
BACKGROUND: Patients of esophageal cancer with a synchronous second primary in head and neck region can be treated with definitive radiotherapy but the clinical outcome has been reported to be poor.
METHOD AND DESIGN: This is a single institutional retrospective study. Twenty-five patients fulfilling inclusion and exclusion criteria were evaluated. The survival was analysed using Kaplan-Meir method and their relations with various clinicopathologic parameters were compared.
RESULTS: After a median follow-up time of 14 months, the 1 year and 2 year survival was 60% and 17% respectively. Significant improvement in overall survival was observed in patients with early staged esophageal cancer then locally advanced disease (P = 0.03). Patients with locally advanced head and neck cancer had poor survival than with early stage disease (P = 0.06). Those who received concurrent chemotherapy had better survival than those with radiotherapy alone. 40% patients developed grade III & IV dermatitis and 48% patients developed grade III oral mucositis.
CONCLUSION: Chemoradiotherapy can safely be offered to patients with synchronous esophageal and head and neck cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Cancer treatment and research communications - 25(2020) vom: 04., Seite 100248 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sarma, Gautam [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer |
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| Anmerkungen: |
Date Completed 19.11.2021 Date Revised 19.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ctarc.2020.100248 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM318204134 |
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| 245 | 1 | 0 | |a Definitive radiotherapy in patients of synchronous esophageal and head and neck cancer-treatment outcome and toxicity |
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| 500 | |a Date Completed 19.11.2021 | ||
| 500 | |a Date Revised 19.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a AIM: The aim is to retrospectively evaluate the clinical outcomes and treatment related toxicities in patients of synchronous esophageal and head & neck cancer when treated with definitive radiotherapy with or without concurrent chemotherapy | ||
| 520 | |a BACKGROUND: Patients of esophageal cancer with a synchronous second primary in head and neck region can be treated with definitive radiotherapy but the clinical outcome has been reported to be poor | ||
| 520 | |a METHOD AND DESIGN: This is a single institutional retrospective study. Twenty-five patients fulfilling inclusion and exclusion criteria were evaluated. The survival was analysed using Kaplan-Meir method and their relations with various clinicopathologic parameters were compared | ||
| 520 | |a RESULTS: After a median follow-up time of 14 months, the 1 year and 2 year survival was 60% and 17% respectively. Significant improvement in overall survival was observed in patients with early staged esophageal cancer then locally advanced disease (P = 0.03). Patients with locally advanced head and neck cancer had poor survival than with early stage disease (P = 0.06). Those who received concurrent chemotherapy had better survival than those with radiotherapy alone. 40% patients developed grade III & IV dermatitis and 48% patients developed grade III oral mucositis | ||
| 520 | |a CONCLUSION: Chemoradiotherapy can safely be offered to patients with synchronous esophageal and head and neck cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Esophagus | |
| 650 | 4 | |a Head & neck | |
| 650 | 4 | |a Radiotherapy | |
| 650 | 4 | |a Synchronous | |
| 700 | 1 | |a Nath, Jyotiman |e verfasserin |4 aut | |
| 700 | 1 | |a Medhi, Partha P |e verfasserin |4 aut | |
| 700 | 1 | |a Momin, Faridha J |e verfasserin |4 aut | |
| 700 | 1 | |a Kalita, Apurba K |e verfasserin |4 aut | |
| 700 | 1 | |a Bhattacharyya, Mouchumee |e verfasserin |4 aut | |
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