Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain : nationwide seroepidemiological study
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVE: To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes.
DESIGN: Nationwide seroepidemiological study.
SETTING: First wave of covid-19 pandemic in Spain.
PARTICIPANTS: Community dwelling individuals of all ages.
MAIN OUTCOME MEASURES: The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 (the number of covid-19 deaths and excess deaths divided by the estimated number of SARS-CoV-2 infections) in the community dwelling Spanish population. Deaths with laboratory confirmed covid-19 were obtained from the National Epidemiological Surveillance Network (RENAVE) and excess all cause deaths from the Monitoring Mortality System (MoMo), up to 15 July 2020. SARS-CoV-2 infections in Spain were derived from the estimated seroprevalence by a chemiluminescent microparticle immunoassay for IgG antibodies in 61 098 participants in the ENE-COVID nationwide seroepidemiological survey between 27 April and 22 June 2020.
RESULTS: The overall infection fatality risk was 0.8% (19 228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths and 1.1% (24 778 of 2.3 million infected individuals, 1.0% to 1.2%) for excess deaths. The infection fatality risk was 1.1% (95% confidence interval 1.0% to 1.2%) to 1.4% (1.3% to 1.5%) in men and 0.6% (0.5% to 0.6%) to 0.8% (0.7% to 0.8%) in women. The infection fatality risk increased sharply after age 50, ranging from 11.6% (8.1% to 16.5%) to 16.4% (11.4% to 23.2%) in men aged 80 or more and from 4.6% (3.4% to 6.3%) to 6.5% (4.7% to 8.8%) in women aged 80 or more.
CONCLUSION: The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:371 |
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| Enthalten in: |
BMJ (Clinical research ed.) - 371(2020) vom: 27. Nov., Seite m4509 |
| Sprache: |
Englisch |
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| Links: |
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| Anmerkungen: |
Date Completed 15.12.2020 Date Revised 30.03.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bmj.m4509 |
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| Förderinstitution / Projekttitel: |
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NLM318134438 |
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| 245 | 1 | 0 | |a Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain |b nationwide seroepidemiological study |
| 264 | 1 | |c 2020 | |
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| 500 | |a Date Completed 15.12.2020 | ||
| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVE: To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes | ||
| 520 | |a DESIGN: Nationwide seroepidemiological study | ||
| 520 | |a SETTING: First wave of covid-19 pandemic in Spain | ||
| 520 | |a PARTICIPANTS: Community dwelling individuals of all ages | ||
| 520 | |a MAIN OUTCOME MEASURES: The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 (the number of covid-19 deaths and excess deaths divided by the estimated number of SARS-CoV-2 infections) in the community dwelling Spanish population. Deaths with laboratory confirmed covid-19 were obtained from the National Epidemiological Surveillance Network (RENAVE) and excess all cause deaths from the Monitoring Mortality System (MoMo), up to 15 July 2020. SARS-CoV-2 infections in Spain were derived from the estimated seroprevalence by a chemiluminescent microparticle immunoassay for IgG antibodies in 61 098 participants in the ENE-COVID nationwide seroepidemiological survey between 27 April and 22 June 2020 | ||
| 520 | |a RESULTS: The overall infection fatality risk was 0.8% (19 228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths and 1.1% (24 778 of 2.3 million infected individuals, 1.0% to 1.2%) for excess deaths. The infection fatality risk was 1.1% (95% confidence interval 1.0% to 1.2%) to 1.4% (1.3% to 1.5%) in men and 0.6% (0.5% to 0.6%) to 0.8% (0.7% to 0.8%) in women. The infection fatality risk increased sharply after age 50, ranging from 11.6% (8.1% to 16.5%) to 16.4% (11.4% to 23.2%) in men aged 80 or more and from 4.6% (3.4% to 6.3%) to 6.5% (4.7% to 8.8%) in women aged 80 or more | ||
| 520 | |a CONCLUSION: The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
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| 700 | 1 | |a Oteo Iglesias, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Pérez Olmeda, María Teresa |e investigator |4 oth | |
| 700 | 1 | |a Cruz, Israel |e investigator |4 oth | |
| 700 | 1 | |a Fernández Martínez, Maria Elena |e investigator |4 oth | |
| 700 | 1 | |a Rodríguez-Cabrera, Francisco D |e investigator |4 oth | |
| 700 | 1 | |a Hernán, Miguel A |e investigator |4 oth | |
| 700 | 1 | |a Padrones Fernández, Susana |e investigator |4 oth | |
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| 700 | 1 | |a Navarro Marí, José M |e investigator |4 oth | |
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| 700 | 1 | |a Rodríguez-Iglesias, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Calvo Gascón, Ana María |e investigator |4 oth | |
| 700 | 1 | |a Lou Alcaine, María Luz |e investigator |4 oth | |
| 700 | 1 | |a Donate Suárez, Ignacio |e investigator |4 oth | |
| 700 | 1 | |a Suárez Álvarez, Oscar |e investigator |4 oth | |
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| 700 | 1 | |a Villafáfila Gomila, Carlos Javier |e investigator |4 oth | |
| 700 | 1 | |a Carbo Saladrigas, Lluis |e investigator |4 oth | |
| 700 | 1 | |a Hurtado Fernández, Adoración |e investigator |4 oth | |
| 700 | 1 | |a Oliver, Antonio |e investigator |4 oth | |
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| 700 | 1 | |a De Benito Población, Inés |e investigator |4 oth | |
| 700 | 1 | |a Celada Pérez, María Sagrario |e investigator |4 oth | |
| 700 | 1 | |a Vallés Fernández, María Natalia |e investigator |4 oth | |
| 700 | 1 | |a Maté Enríquez, Tomás |e investigator |4 oth | |
| 700 | 1 | |a Villa Arranz, Miguel |e investigator |4 oth | |
| 700 | 1 | |a Domínguez-Gil González, Marta |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Natal, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Megías Lobón, Gregoria |e investigator |4 oth | |
| 700 | 1 | |a Muñoz Bellido, Juan Luis |e investigator |4 oth | |
| 700 | 1 | |a Ciruela, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Mas I Casals, Ariadna |e investigator |4 oth | |
| 700 | 1 | |a Doladé Botías, Maria |e investigator |4 oth | |
| 700 | 1 | |a Marcos Maeso, M Angeles |e investigator |4 oth | |
| 700 | 1 | |a Pérez Del Campo, Dúnia |e investigator |4 oth | |
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| 700 | 1 | |a Limón Ramírez, Ramón |e investigator |4 oth | |
| 700 | 1 | |a Elías Retamosa, Maria Francisca |e investigator |4 oth | |
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| 700 | 1 | |a Ramírez Almagro, Cristóbal |e investigator |4 oth | |
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