Cytokine storm of a different flavour : The different cytokine signature of SARS-CoV-2, the cause of COVID-19, from the original SARS outbreak
Copyright © 2020. Published by Elsevier Ltd..
Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature described in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). We also documented evidence of a compromised T-cell IFN-γ response in two of these patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Journal of global antimicrobial resistance - 24(2021) vom: 25. März, Seite 90-92 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Griffin, Daniel O [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 14.04.2021 Date Revised 14.04.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jgar.2020.11.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM318092190 |
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| 520 | |a Copyright © 2020. Published by Elsevier Ltd. | ||
| 520 | |a Here we present a case series of three patients with COVID-19 (coronavirus disease 2019) who had a cytokine panel that revealed elevation of interleukin-6 (IL-6) but normal levels of interleukin-10 (IL-10), interferon-gamma (INF-γ) and interleukin-8 (IL-8), in contrast to the cytokine signature described in severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). We also documented evidence of a compromised T-cell IFN-γ response in two of these patients | ||
| 650 | 4 | |a Case Reports | |
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| 650 | 4 | |a Cytokine storm | |
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| 650 | 4 | |a SARS-CoV-2 | |
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| 700 | 1 | |a Jensen, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Mushmoom |e verfasserin |4 aut | |
| 700 | 1 | |a Chin, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Chin, Kelly |e verfasserin |4 aut | |
| 700 | 1 | |a Saad, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Parnell, Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Awwad, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Darshan |e verfasserin |4 aut | |
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