iPhosS(Deep)-PseAAC : Identification of Phosphoserine Sites in Proteins Using Deep Learning on General Pseudo Amino Acid Compositions
Among all the PTMs, the protein phosphorylation is pivotal for various pathological and physiological processes. About 30 percent of eukaryotic proteins undergo the phosphorylation modification, leading to various changes in conformation, function, stability, localization, and so forth. In eukaryotic proteins, phosphorylation occurs on serine (S), Threonine (T) and Tyrosine (Y) residues. Among these all, serine phosphorylation has its own importance as it is associated with various importance biological processes, including energy metabolism, signal transduction pathways, cell cycling, and apoptosis. Thus, its identification is important, however, the in vitro, ex vivo and in vivo identification can be laborious, time-taking and costly. There is a dire need of an efficient and accurate computational model to help researchers and biologists identifying these sites, in an easy manner. Herein, we propose a novel predictor for identification of Phosphoserine sites (PhosS) in proteins, by integrating the Chou's Pseudo Amino Acid Composition (PseAAC) with deep features. We used well-known DNNs for both the tasks of learning a feature representation of peptide sequences and performing classifications. Among different DNNs, the best score is shown by Covolutional Neural Network based model which renders CNN based prediction model the best for Phosphoserine prediction. Based on these results, it is concluded that the proposed model can help to identify PhosS sites in a very efficient and accurate manner which can help scientists understand the mechanism of this modification in proteins.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
IEEE/ACM transactions on computational biology and bioinformatics - 19(2022), 3 vom: 26. Mai, Seite 1703-1714 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Naseer, Sheraz [VerfasserIn] |
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| Links: |
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| Themen: |
17885-08-4 |
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| Anmerkungen: |
Date Completed 08.06.2022 Date Revised 08.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1109/TCBB.2020.3040747 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM318088592 |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a Among all the PTMs, the protein phosphorylation is pivotal for various pathological and physiological processes. About 30 percent of eukaryotic proteins undergo the phosphorylation modification, leading to various changes in conformation, function, stability, localization, and so forth. In eukaryotic proteins, phosphorylation occurs on serine (S), Threonine (T) and Tyrosine (Y) residues. Among these all, serine phosphorylation has its own importance as it is associated with various importance biological processes, including energy metabolism, signal transduction pathways, cell cycling, and apoptosis. Thus, its identification is important, however, the in vitro, ex vivo and in vivo identification can be laborious, time-taking and costly. There is a dire need of an efficient and accurate computational model to help researchers and biologists identifying these sites, in an easy manner. Herein, we propose a novel predictor for identification of Phosphoserine sites (PhosS) in proteins, by integrating the Chou's Pseudo Amino Acid Composition (PseAAC) with deep features. We used well-known DNNs for both the tasks of learning a feature representation of peptide sequences and performing classifications. Among different DNNs, the best score is shown by Covolutional Neural Network based model which renders CNN based prediction model the best for Phosphoserine prediction. Based on these results, it is concluded that the proposed model can help to identify PhosS sites in a very efficient and accurate manner which can help scientists understand the mechanism of this modification in proteins | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 7 | |a Proteins |2 NLM | |
| 650 | 7 | |a Phosphoserine |2 NLM | |
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| 650 | 7 | |a Serine |2 NLM | |
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| 700 | 1 | |a Hussain, Waqar |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Yaser Daanial |e verfasserin |4 aut | |
| 700 | 1 | |a Rasool, Nouman |e verfasserin |4 aut | |
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