Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project)
© 2020 Wiley Periodicals LLC..
BACKGROUND: Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear.
METHODS: We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively.
RESULTS: Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count ≤500 cells/μL at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes.
CONCLUSIONS: Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902).
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
---|---|
Enthalten in: |
Transplant infectious disease : an official journal of the Transplantation Society - 23(2021), 3 vom: 22. Juni, Seite e13520 |
Sprache: |
Englisch |
---|
Links: |
---|
Anmerkungen: |
Date Completed 03.08.2021 Date Revised 03.08.2021 published: Print-Electronic ClinicalTrials.gov: NCT02852902 Citation Status MEDLINE |
---|
doi: |
10.1111/tid.13520 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM317894021 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM317894021 | ||
003 | DE-627 | ||
005 | 20231225164223.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1111/tid.13520 |2 doi | |
028 | 5 | 2 | |a pubmed24n1059.xml |
035 | |a (DE-627)NLM317894021 | ||
035 | |a (NLM)33222379 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Pierrotti, Ligia C |e verfasserin |4 aut | |
245 | 1 | 0 | |a Efficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project) |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 03.08.2021 | ||
500 | |a Date Revised 03.08.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a ClinicalTrials.gov: NCT02852902 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2020 Wiley Periodicals LLC. | ||
520 | |a BACKGROUND: Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney transplant recipients (KTRs) remains unclear | ||
520 | |a METHODS: We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively | ||
520 | |a RESULTS: Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count ≤500 cells/μL at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%, mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes | ||
520 | |a CONCLUSIONS: Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902) | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a bloodstream infection | |
650 | 4 | |a carbapenem-sparing regimen | |
650 | 4 | |a extended-spectrum β-lactamase-producing Enterobacterales | |
650 | 4 | |a kidney transplantation | |
650 | 4 | |a outcomes | |
650 | 4 | |a urinary tract infection | |
650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
650 | 7 | |a Carbapenems |2 NLM | |
650 | 7 | |a Lactams |2 NLM | |
650 | 7 | |a beta-Lactamase Inhibitors |2 NLM | |
650 | 7 | |a beta-Lactamases |2 NLM | |
650 | 7 | |a EC 3.5.2.6 |2 NLM | |
700 | 1 | |a Pérez-Nadales, Elena |e verfasserin |4 aut | |
700 | 1 | |a Fernández-Ruiz, Mario |e verfasserin |4 aut | |
700 | 1 | |a Gutiérrez-Gutiérrez, Belén |e verfasserin |4 aut | |
700 | 1 | |a Tan, Ban Hock |e verfasserin |4 aut | |
700 | 1 | |a Carratalà, Jordi |e verfasserin |4 aut | |
700 | 1 | |a Oriol, Isabel |e verfasserin |4 aut | |
700 | 1 | |a Paul, Mical |e verfasserin |4 aut | |
700 | 1 | |a Cohen-Sinai, Noa |e verfasserin |4 aut | |
700 | 1 | |a López-Medrano, Francisco |e verfasserin |4 aut | |
700 | 1 | |a San-Juan, Rafael |e verfasserin |4 aut | |
700 | 1 | |a Montejo, Miguel |e verfasserin |4 aut | |
700 | 1 | |a Freire, Maristela P |e verfasserin |4 aut | |
700 | 1 | |a Cordero, Elisa |e verfasserin |4 aut | |
700 | 1 | |a David, Miruna D |e verfasserin |4 aut | |
700 | 1 | |a Merino, Esperanza |e verfasserin |4 aut | |
700 | 1 | |a Mehta Steinke, Seema |e verfasserin |4 aut | |
700 | 1 | |a Grossi, Paolo A |e verfasserin |4 aut | |
700 | 1 | |a Cano, Ángela |e verfasserin |4 aut | |
700 | 1 | |a Seminari, Elena M |e verfasserin |4 aut | |
700 | 1 | |a Valerio, Maricela |e verfasserin |4 aut | |
700 | 1 | |a Gunseren, Filiz |e verfasserin |4 aut | |
700 | 1 | |a Rana, Meenakshi |e verfasserin |4 aut | |
700 | 1 | |a Mularoni, Alessandra |e verfasserin |4 aut | |
700 | 1 | |a Martín-Dávila, Pilar |e verfasserin |4 aut | |
700 | 1 | |a van Delden, Christian |e verfasserin |4 aut | |
700 | 1 | |a Hamiyet Demirkaya, Melike |e verfasserin |4 aut | |
700 | 1 | |a Koçak Tufan, Zeliha |e verfasserin |4 aut | |
700 | 1 | |a Loeches, Belén |e verfasserin |4 aut | |
700 | 1 | |a Iyer, Ranganathan N |e verfasserin |4 aut | |
700 | 1 | |a Soldani, Fabio |e verfasserin |4 aut | |
700 | 1 | |a Eriksson, Britt-Marie |e verfasserin |4 aut | |
700 | 1 | |a Pilmis, Benoît |e verfasserin |4 aut | |
700 | 1 | |a Rizzi, Marco |e verfasserin |4 aut | |
700 | 1 | |a Coussement, Julien |e verfasserin |4 aut | |
700 | 1 | |a Clemente, Wanessa T |e verfasserin |4 aut | |
700 | 1 | |a Roilides, Emmanuel |e verfasserin |4 aut | |
700 | 1 | |a Pascual, Álvaro |e verfasserin |4 aut | |
700 | 1 | |a Martínez-Martínez, Luis |e verfasserin |4 aut | |
700 | 1 | |a Rodríguez-Baño, Jesús |e verfasserin |4 aut | |
700 | 1 | |a Torre-Cisneros, Julian |e verfasserin |4 aut | |
700 | 1 | |a Aguado, José María |e verfasserin |4 aut | |
700 | 0 | |a Investigators from the REIPI/INCREMENT-SOT Group |e verfasserin |4 aut | |
700 | 1 | |a Kee, Terence Yi Shern |e investigator |4 oth | |
700 | 1 | |a Sabé, Núria |e investigator |4 oth | |
700 | 1 | |a Camoez, Mariana |e investigator |4 oth | |
700 | 1 | |a Domínguez, María A |e investigator |4 oth | |
700 | 1 | |a Koppel, Fidi |e investigator |4 oth | |
700 | 1 | |a Lora-Tamayo, Jaime |e investigator |4 oth | |
700 | 1 | |a Lopez-Soria, Leyre |e investigator |4 oth | |
700 | 1 | |a David-Neto, Elias |e investigator |4 oth | |
700 | 1 | |a de Paula E Flávia Rossi, Flávio Jota |e investigator |4 oth | |
700 | 1 | |a Lepe, Jose Antonio |e investigator |4 oth | |
700 | 1 | |a Blanco, Gabriel Bernal |e investigator |4 oth | |
700 | 1 | |a Martín-Gandul, Cecilia |e investigator |4 oth | |
700 | 1 | |a Balibrea, Noelia |e investigator |4 oth | |
700 | 1 | |a Franco, Antonio |e investigator |4 oth | |
700 | 1 | |a Avery, Robin |e investigator |4 oth | |
700 | 1 | |a Ostrander, Darin |e investigator |4 oth | |
700 | 1 | |a Dalla Gasperina, Daniela |e investigator |4 oth | |
700 | 1 | |a Rovelli, Cristina |e investigator |4 oth | |
700 | 1 | |a Natera, Alejandra M |e investigator |4 oth | |
700 | 1 | |a Recio-Rufián, Manuel |e investigator |4 oth | |
700 | 1 | |a Guzmán-Puche, Julia |e investigator |4 oth | |
700 | 1 | |a Leoni, Cristina |e investigator |4 oth | |
700 | 1 | |a Muñoz, Patricia |e investigator |4 oth | |
700 | 1 | |a Sánchez-Carrillo, Carlos |e investigator |4 oth | |
700 | 1 | |a Lardo, Sara |e investigator |4 oth | |
700 | 1 | |a Altman, Deena Rose |e investigator |4 oth | |
700 | 1 | |a Fortún, Jesús |e investigator |4 oth | |
700 | 1 | |a Escudero, Rosa |e investigator |4 oth | |
700 | 1 | |a Gioia, Francesca |e investigator |4 oth | |
700 | 1 | |a Muller, Nicolas J |e investigator |4 oth | |
700 | 1 | |a Manuel, Oriol |e investigator |4 oth | |
700 | 1 | |a Arslan, Hande |e investigator |4 oth | |
700 | 1 | |a Hasanoglu, Imran |e investigator |4 oth | |
700 | 1 | |a López Oliva, Maria |e investigator |4 oth | |
700 | 1 | |a Chiese, Sheila |e investigator |4 oth | |
700 | 1 | |a Salerno, Nicola Duccio |e investigator |4 oth | |
700 | 1 | |a Lortholary, Olivier |e investigator |4 oth | |
700 | 1 | |a Scemla, Anne |e investigator |4 oth | |
700 | 1 | |a Grazia Calvi, Elisa |e investigator |4 oth | |
700 | 1 | |a Dewispelaere, Laurent |e investigator |4 oth | |
700 | 1 | |a Mourão, Paulo Henrique Orlandi |e investigator |4 oth | |
700 | 1 | |a Pyrpasopoulou, Athina |e investigator |4 oth | |
700 | 1 | |a Romiopoulos, Iordanis |e investigator |4 oth | |
700 | 1 | |a Iosifidis, Elias |e investigator |4 oth | |
700 | 1 | |a Abdala, Edson |e investigator |4 oth | |
700 | 1 | |a Bodro, Marta |e investigator |4 oth | |
700 | 1 | |a Strabelli, Tania Mara Varejão |e investigator |4 oth | |
700 | 1 | |a Fariñas, María Carmen |e investigator |4 oth | |
700 | 1 | |a Lowman, Warren |e investigator |4 oth | |
700 | 1 | |a Falcone, Marco |e investigator |4 oth | |
700 | 1 | |a Kazak, Esra |e investigator |4 oth | |
700 | 1 | |a Tumbarello, Mario |e investigator |4 oth | |
700 | 1 | |a Lease, Erika |e investigator |4 oth | |
700 | 1 | |a Nestorova, Nina |e investigator |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Transplant infectious disease : an official journal of the Transplantation Society |d 1999 |g 23(2021), 3 vom: 22. Juni, Seite e13520 |w (DE-627)NLM113005482 |x 1399-3062 |7 nnns |
773 | 1 | 8 | |g volume:23 |g year:2021 |g number:3 |g day:22 |g month:06 |g pages:e13520 |
856 | 4 | 0 | |u http://dx.doi.org/10.1111/tid.13520 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 23 |j 2021 |e 3 |b 22 |c 06 |h e13520 |