The Association Between the Mediterranean Lifestyle Index and All-Cause Mortality in the Seguimiento Universidad de Navarra Cohort
Copyright © 2020 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved..
INTRODUCTION: Overall lifestyle patterns rather than individual factors may exert greater reductions on chronic disease risk and mortality. The objective is to study the association between a Mediterranean lifestyle index and all-cause and cause-specific mortality.
METHODS: Investigators analyzed data from 20,494 participants in the Seguimiento Universidad de Navarra cohort in 2019. The Mediterranean lifestyle index is composed of 28 items on food consumption, dietary habits, physical activity, rest, and social interactions that score 0 or 1 point; scores theoretically could range from 0 to 28 points.
RESULTS: After a median follow-up of 12.1 years, 407 deaths were observed. In the multivariable-adjusted model, high adherence (>14 points) to the Mediterranean lifestyle was associated with a 41% relative reduction in all-cause mortality (hazard ratio=0.59, 95% CI=0.42, 0.83) compared with low adherence (3-10 points, p<0.001 for trend). For each additional point, the multivariable hazard ratios for all-cause mortality were 0.95 (95% CI=0.89, 1.02) for food consumption; 1.00 (95% CI=0.92, 1.08) for dietary habits; and 0.73 (95% CI=0.66, 0.80) for physical activity, rest, social habits, and conviviality. Significant interaction with age at last contact (p<0.001) suggested a lower risk for each additional point among participants aged ≥50 years (hazard ratio=0.50, 95% CI=0.34, 0.74), whereas no association was found for participants aged <50 years (hazard ratio=1.15, 95% CI=0.54, 2.44).
CONCLUSIONS: Adherence to a Mediterranean lifestyle may reduce the risk of mortality in a Spanish cohort of university graduates. Inverse associations were found for the overall Mediterranean lifestyle score and lifestyle block, whereas no associations were observed for the dietary blocks. Future research should consider the Mediterranean lifestyle beyond the Mediterranean diet in different populations for the promotion of healthy longevity.
TRIAL REGISTRATION: This study is registered at www.clinicaltrials.gov NCT02669602.
| Errataetall: |
ErratumIn: Am J Prev Med. 2022 Jun;62(6):963. - PMID 35597570 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
American journal of preventive medicine - 59(2020), 6 vom: 21. Dez., Seite e239-e248 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hershey, Maria S [VerfasserIn] |
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| Anmerkungen: |
Date Completed 23.06.2021 Date Revised 21.05.2022 published: Print-Electronic ClinicalTrials.gov: NCT02669602 ErratumIn: Am J Prev Med. 2022 Jun;62(6):963. - PMID 35597570 Citation Status MEDLINE |
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| doi: |
10.1016/j.amepre.2020.06.014 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM317877844 |
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| 100 | 1 | |a Hershey, Maria S |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Association Between the Mediterranean Lifestyle Index and All-Cause Mortality in the Seguimiento Universidad de Navarra Cohort |
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| 500 | |a Date Completed 23.06.2021 | ||
| 500 | |a Date Revised 21.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT02669602 | ||
| 500 | |a ErratumIn: Am J Prev Med. 2022 Jun;62(6):963. - PMID 35597570 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2020 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a INTRODUCTION: Overall lifestyle patterns rather than individual factors may exert greater reductions on chronic disease risk and mortality. The objective is to study the association between a Mediterranean lifestyle index and all-cause and cause-specific mortality | ||
| 520 | |a METHODS: Investigators analyzed data from 20,494 participants in the Seguimiento Universidad de Navarra cohort in 2019. The Mediterranean lifestyle index is composed of 28 items on food consumption, dietary habits, physical activity, rest, and social interactions that score 0 or 1 point; scores theoretically could range from 0 to 28 points | ||
| 520 | |a RESULTS: After a median follow-up of 12.1 years, 407 deaths were observed. In the multivariable-adjusted model, high adherence (>14 points) to the Mediterranean lifestyle was associated with a 41% relative reduction in all-cause mortality (hazard ratio=0.59, 95% CI=0.42, 0.83) compared with low adherence (3-10 points, p<0.001 for trend). For each additional point, the multivariable hazard ratios for all-cause mortality were 0.95 (95% CI=0.89, 1.02) for food consumption; 1.00 (95% CI=0.92, 1.08) for dietary habits; and 0.73 (95% CI=0.66, 0.80) for physical activity, rest, social habits, and conviviality. Significant interaction with age at last contact (p<0.001) suggested a lower risk for each additional point among participants aged ≥50 years (hazard ratio=0.50, 95% CI=0.34, 0.74), whereas no association was found for participants aged <50 years (hazard ratio=1.15, 95% CI=0.54, 2.44) | ||
| 520 | |a CONCLUSIONS: Adherence to a Mediterranean lifestyle may reduce the risk of mortality in a Spanish cohort of university graduates. Inverse associations were found for the overall Mediterranean lifestyle score and lifestyle block, whereas no associations were observed for the dietary blocks. Future research should consider the Mediterranean lifestyle beyond the Mediterranean diet in different populations for the promotion of healthy longevity | ||
| 520 | |a TRIAL REGISTRATION: This study is registered at www.clinicaltrials.gov NCT02669602 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Fernandez-Montero, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Sotos-Prieto, Mercedes |e verfasserin |4 aut | |
| 700 | 1 | |a Kales, Stefanos |e verfasserin |4 aut | |
| 700 | 1 | |a Gea, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Estigarribia, Liz |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Villegas, Almundena |e verfasserin |4 aut | |
| 700 | 1 | |a Díaz-Gutiérrez, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-González, Miguel A |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Canela, Miguel |e verfasserin |4 aut | |
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