Traumatic brain injury with concomitant injury to the spleen : characteristics and mortality of a high-risk trauma cohort from the TraumaRegister DGU®
© 2020. The Author(s)..
PURPOSE: Based on the hypothesis that systemic inflammation contributes to secondary injury after initial traumatic brain injury (TBI), this study aims to describe the effect of splenectomy on mortality in trauma patients with TBI and splenic injury.
METHODS: A retrospective cohort analysis of patients prospectively registered into the TraumaRegister DGU® (TR-DGU) with TBI (AISHead ≥ 3) combined with injury to the spleen (AISSpleen ≥ 1) was conducted. Multivariable logistic regression modeling was performed to adjust for confounding factors and to assess the independent effect of splenectomy on in-hospital mortality.
RESULTS: The cohort consisted of 1114 patients out of which 328 (29.4%) had undergone early splenectomy. Patients with splenectomy demonstrated a higher Injury Severity Score (median: 34 vs. 44, p < 0.001) and lower Glasgow Coma Scale (median: 9 vs. 7, p = 0.014) upon admission. Splenectomized patients were more frequently hypotensive upon admission (19.8% vs. 38.0%, p < 0.001) and in need for blood transfusion (30.3% vs. 61.0%, p < 0.001). The mortality was 20.7% in the splenectomy group and 10.3% in the remaining cohort. After adjustment for confounding factors, early splenectomy was not found to exert a significant effect on in-hospital mortality (OR 1.29 (0.67-2.50), p = 0.45).
CONCLUSION: Trauma patients with TBI and spleen injury undergoing splenectomy demonstrate a more severe injury pattern, more compromised hemodynamic status and higher in-hospital mortality than patients without splenectomy. Adjustment for confounding factors reveals that the splenectomy procedure itself is not independently associated with survival.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
European journal of trauma and emergency surgery : official publication of the European Trauma Society - 48(2022), 6 vom: 18. Dez., Seite 4451-4459 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mader, Marius Marc-Daniel [VerfasserIn] |
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| Links: |
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| Themen: |
Humans |
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| Anmerkungen: |
Date Completed 02.12.2022 Date Revised 03.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00068-020-01544-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31773430X |
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| 100 | 1 | |a Mader, Marius Marc-Daniel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Traumatic brain injury with concomitant injury to the spleen |b characteristics and mortality of a high-risk trauma cohort from the TraumaRegister DGU® |
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| 500 | |a Date Completed 02.12.2022 | ||
| 500 | |a Date Revised 03.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2020. The Author(s). | ||
| 520 | |a PURPOSE: Based on the hypothesis that systemic inflammation contributes to secondary injury after initial traumatic brain injury (TBI), this study aims to describe the effect of splenectomy on mortality in trauma patients with TBI and splenic injury | ||
| 520 | |a METHODS: A retrospective cohort analysis of patients prospectively registered into the TraumaRegister DGU® (TR-DGU) with TBI (AISHead ≥ 3) combined with injury to the spleen (AISSpleen ≥ 1) was conducted. Multivariable logistic regression modeling was performed to adjust for confounding factors and to assess the independent effect of splenectomy on in-hospital mortality | ||
| 520 | |a RESULTS: The cohort consisted of 1114 patients out of which 328 (29.4%) had undergone early splenectomy. Patients with splenectomy demonstrated a higher Injury Severity Score (median: 34 vs. 44, p < 0.001) and lower Glasgow Coma Scale (median: 9 vs. 7, p = 0.014) upon admission. Splenectomized patients were more frequently hypotensive upon admission (19.8% vs. 38.0%, p < 0.001) and in need for blood transfusion (30.3% vs. 61.0%, p < 0.001). The mortality was 20.7% in the splenectomy group and 10.3% in the remaining cohort. After adjustment for confounding factors, early splenectomy was not found to exert a significant effect on in-hospital mortality (OR 1.29 (0.67-2.50), p = 0.45) | ||
| 520 | |a CONCLUSION: Trauma patients with TBI and spleen injury undergoing splenectomy demonstrate a more severe injury pattern, more compromised hemodynamic status and higher in-hospital mortality than patients without splenectomy. Adjustment for confounding factors reveals that the splenectomy procedure itself is not independently associated with survival | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Splenectomy | |
| 650 | 4 | |a Traumatic brain injury | |
| 700 | 1 | |a Lefering, Rolf |e verfasserin |4 aut | |
| 700 | 1 | |a Westphal, Manfred |e verfasserin |4 aut | |
| 700 | 1 | |a Maegele, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Czorlich, Patrick |e verfasserin |4 aut | |
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