Self-assembling peptide-etoposide nanofibers for overcoming multidrug resistance
We developed a new strategy to overcome the MDR of etoposide using self-assembling nanofibers. Compared with the original etoposide, the inhibitory activity of Nap-GFFpYK-etoposide1/2 against murine Lewis lung cancer or breast cancer cells was increased 10 times, and 20 times on these cells with artificially overexpressed MDR1. Our method to synthesize and separate etoposide isomers provides a new strategy for the modification of this drug.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 56(2020), 97 vom: 18. Dez., Seite 15321-15324 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Li-Song [VerfasserIn] |
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| Links: |
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| Themen: |
6PLQ3CP4P3 |
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| Anmerkungen: |
Date Completed 01.06.2021 Date Revised 01.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d0cc06387h |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM31773007X |
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| 520 | |a We developed a new strategy to overcome the MDR of etoposide using self-assembling nanofibers. Compared with the original etoposide, the inhibitory activity of Nap-GFFpYK-etoposide1/2 against murine Lewis lung cancer or breast cancer cells was increased 10 times, and 20 times on these cells with artificially overexpressed MDR1. Our method to synthesize and separate etoposide isomers provides a new strategy for the modification of this drug | ||
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| 700 | 1 | |a Xi, Zhen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Lu-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhi-Song |e verfasserin |4 aut | |
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